{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:36:59Z","timestamp":1793137019098,"version":"4.5.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:00:00Z","timestamp":1503619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T00:00:00Z","timestamp":1503619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Data on procedural complications and long term survival after alcohol septal ablation (ASA) in Chinese patients with obstructive hypertrophic cardiomyopathy (HOCM) are lacking. We aimed to investigate long-term survival of HOCM patients after ASA and compared to the non-obstructive hypertrophic cardiomyopathy(NOHCM). A total of 233 patients with HOCM and a peak pressure gradient of \u226550\u2009mm Hg at rest or with provocation were consecutively enrolled from Fuwai Hospital in China between 2000 and 2012. Another 297 patients without left ventricular outflow tract obstruction were regarded as control group. Periprocedural mortality of ASA were low (0.89%). Periprocedural lethal ventricular arrhythmia occurred in 9 patients (4.0%). Alcohol volume (RR 1.44, 95% CI: 1.03\u20132.03, P\u2009=\u20090.034) and age \u226440 years old (RR 4.63, 95% CI: 1.07\u201320.0, P\u2009=\u20090.040) were independent predictors for periprocedural lethal ventricular arrhythmia. The 10- year overall survival was 94.6% in the ASA group, similar with 92.9% in the NOHCM group (P\u2009=\u20090.930). In conclusion, periprocedural mortality and complications were rare in ASA. Long term survival after ASA were satisfactory and comparable to NOHCM. Patients under 40 years old should be more cautious undergoing ASA, for these patients were more likely to endure lethal ventricular arrhythmia during periprocedural period of ASA.<\/jats:p>","DOI":"10.1038\/s41598-017-10144-0","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T14:22:05Z","timestamp":1503325325000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Procedural complication and long term outcomes after alcohol septal ablation in patients with obstructive hypertrophic cardiomyopathy: data from China"],"prefix":"10.1038","volume":"7","author":[{"given":"Shuo-yan","family":"An","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-mei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,25]]},"reference":[{"key":"10144_CR1","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/S0140-6736(12)60397-3","volume":"381","author":"BJ Maron","year":"2013","unstructured":"Maron, B. 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M. et al. 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). Eur Heart J \n                           35, 2733\u20132779, doi:10.1093\/eurheartj\/ehu284 (2014).","journal-title":"Eur Heart J"},{"key":"10144_CR4","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.amjcard.2009.02.056","volume":"104","author":"PA Noseworthy","year":"2009","unstructured":"Noseworthy, P. A. et al. Ventricular arrhythmia following alcohol septal ablation for obstructive hypertrophic cardiomyopathy. The American journal of cardiology \n                           104, 128\u2013132, doi:10.1016\/j.amjcard.2009.02.056 (2009).","journal-title":"The American journal of cardiology"},{"key":"10144_CR5","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.jcin.2014.05.023","volume":"7","author":"RC Steggerda","year":"2014","unstructured":"Steggerda, R. C. et al. Periprocedural complications and long-term outcome after alcohol septal ablation versus surgical myectomy in hypertrophic obstructive cardiomyopathy: a single-center experience. JACC. Cardiovascular interventions \n                           7, 1227\u20131234, doi:10.1016\/j.jcin.2014.05.023 (2014).","journal-title":"JACC. Cardiovascular interventions"},{"key":"10144_CR6","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1016\/j.amjcard.2014.07.075","volume":"114","author":"SS Panaich","year":"2014","unstructured":"Panaich, S. S. et al. Results of ventricular septal myectomy and hypertrophic cardiomyopathy (from Nationwide Inpatient Sample [1998\u20132010]). The American journal of cardiology \n                           114, 1390\u20131395, doi:10.1016\/j.amjcard.2014.07.075 (2014).","journal-title":"The American journal of cardiology"},{"key":"10144_CR7","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1093\/eurheartj\/eht495","volume":"35","author":"J Veselka","year":"2014","unstructured":"Veselka, J., Krejci, J., Tomasov, P. & Zemanek, D. Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population. 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