{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:31:31Z","timestamp":1791829891365,"version":"4.3.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To quantify the cross-sectional and longitudinal effects of hyperlipidemia on knee osteoarthritis (KOA), we studied 13,906 middle-aged or older participants from the Dongfeng-Tongji cohort. Physical examinations were performed at baseline and follow-up. Knee pain was diagnosed by self-reported pain or stiffness. Clinical KOA was diagnosed from knee pain complains and clinical X-ray radiographs. The prevalence of knee pain and clinical KOA was 39.0% and 6.7% at baseline, respectively. Hyperlipidemia was associated with knee pain (OR 1.34, 1.23\u20131.45) and clinical KOA (1.34, 1.15\u20131.55). Compared with the participants without hyperlipidemia or use of lipid-lowering drugs, those with hyperlipidemia but no use of lipid-lowering drugs had higher risks of knee pain (1.28, 1.15\u20131.43) and clinical KOA (1.20, 0.97\u20131.48), those with hyperlipidemia and use of lipid-lowering drugs had the highest risks of knee pain (1.40, 1.26\u20131.56) and clinical KOA (1.45, 1.21\u20131.75). The risks were not elevated among participants without hyperlipidemia but using lipid-lowering drugs for prevention of other diseases. Furthermore, each 1-unit increase in triglyceride was associated with 9% and 5% increases in the risk of clinical KOA prevalence and clinical KOA onset, respectively. In conclusion, hyperlipidemia is associated with elevated risks of knee pain and clinical KOA among middle-aged or older adults.<\/jats:p>","DOI":"10.1038\/s41598-017-10158-8","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T04:13:49Z","timestamp":1503461629000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The cross-sectional and longitudinal effect of hyperlipidemia on knee osteoarthritis: Results from the Dongfeng-Tongji cohort in China"],"prefix":"10.1038","volume":"7","author":[{"given":"Min","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangchun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,29]]},"reference":[{"key":"10158_CR1","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1056\/NEJMcp051726","volume":"354","author":"DT Felson","year":"2006","unstructured":"Felson, D. T. Clinical practice. Osteoarthritis of the knee. N. Engl. J. Med. \n                           354, 841\u2013848 (2006).","journal-title":"N. Engl. J. Med."},{"key":"10158_CR2","doi-asserted-by":"crossref","unstructured":"Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet \n                           386, 743\u2013800 (2015).","DOI":"10.1016\/S0140-6736(15)60692-4"},{"key":"10158_CR3","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1016\/S0140-6736(15)61340-X","volume":"386","author":"CJ Murray","year":"2015","unstructured":"Murray, C. J. et al. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990\u20132013: quantifying the epidemiological transition. Lancet \n                           386, 2145\u20132191 (2015).","journal-title":"Lancet"},{"key":"10158_CR4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1136\/ard.2003.006031","volume":"63","author":"A Maetzel","year":"2004","unstructured":"Maetzel, A., Li, L. C., Pencharz, J., Tomlinson, G. & Bombardier, C. The economic burden associated with osteoarthritis, rheumatoid arthritis, and hypertension: a comparative study. Ann. Rheum. Dis. \n                           63, 395\u2013401 (2004).","journal-title":"Ann. Rheum. Dis."},{"key":"10158_CR5","first-page":"165","volume":"34","author":"F Xie","year":"2007","unstructured":"Xie, F. et al. Direct and indirect costs of osteoarthritis in Singapore: a comparative study among multiethnic Asian patients with osteoarthritis. J. Rheumatol. \n                           34, 165\u2013171 (2007).","journal-title":"J. Rheumatol."},{"key":"10158_CR6","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1136\/annrheumdis-2013-204763","volume":"73","author":"M Cross","year":"2014","unstructured":"Cross, M. et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann. Rheum. Dis. \n                           73, 1323\u20131330 (2014).","journal-title":"Ann. Rheum. Dis."},{"key":"10158_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/ar2368","volume":"10","author":"QY Zeng","year":"2008","unstructured":"Zeng, Q. Y. et al. Rheumatic diseases in China. Arthritis Res. Ther. \n                           10, R17 (2008).","journal-title":"Arthritis Res. Ther."},{"key":"10158_CR8","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1093\/rheumatology\/ket222","volume":"52","author":"A Chopra","year":"2013","unstructured":"Chopra, A. The COPCORD world of musculoskeletal pain and arthritis. Rheumatology (Oxford, England) \n                           52, 1925\u20131928 (2013).","journal-title":"Rheumatology (Oxford, England)"},{"key":"10158_CR9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1756-185X.2011.01608.x","volume":"14","author":"M Fransen","year":"2011","unstructured":"Fransen, M. et al. The epidemiology of osteoarthritis in Asia. Int. J. Rheum. Dis. \n                           14, 113\u2013121 (2011).","journal-title":"Int. J. Rheum. Dis."},{"key":"10158_CR10","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/art.39465","volume":"68","author":"X Tang","year":"2016","unstructured":"Tang, X. et al. The Prevalence of Symptomatic Knee Osteoarthritis in China: Results From the China Health and Retirement Longitudinal Study. Arthritis Rheumatol. \n                           68, 648\u2013653 (2016).","journal-title":"Arthritis Rheumatol."},{"key":"10158_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/acr.22641","volume":"68","author":"LB Murphy","year":"2016","unstructured":"Murphy, L. B. et al. Annual Incidence of Knee Symptoms and Four Knee Osteoarthritis Outcomes in the Johnston County Osteoarthritis Project. Arthritis Care. Res. (Hoboken) \n                           68, 55\u201365 (2016).","journal-title":"Arthritis Care. Res. (Hoboken)"},{"key":"10158_CR12","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1136\/ard.2011.154021","volume":"71","author":"AK Wills","year":"2012","unstructured":"Wills, A. K. et al. Life course body mass index and risk of knee osteoarthritis at the age of 53 years: evidence from the 1946 British birth cohort study. Ann. Rheum. Dis. \n                           71, 655\u2013660 (2012).","journal-title":"Ann. Rheum. Dis."},{"key":"10158_CR13","doi-asserted-by":"publisher","first-page":"535","DOI":"10.7326\/0003-4819-116-7-535","volume":"116","author":"DT Felson","year":"1992","unstructured":"Felson, D. T., Zhang, Y., Anthony, J. M., Naimark, A. & Anderson, J. J. Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann. Intern. Med. \n                           116, 535\u2013539 (1992).","journal-title":"Ann. Intern. Med."},{"key":"10158_CR14","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1093\/aje\/152.9.855","volume":"152","author":"EC Lau","year":"2000","unstructured":"Lau, E. C. et al. Factors associated with osteoarthritis of the hip and knee in Hong Kong Chinese: obesity, joint injury, and occupational activities. Am. J. Epidemiol. \n                           152, 855\u2013862 (2000).","journal-title":"Am. J. Epidemiol."},{"key":"10158_CR15","doi-asserted-by":"publisher","first-page":"3981","DOI":"10.1021\/acs.analchem.5b00114","volume":"87","author":"N Georgi","year":"2015","unstructured":"Georgi, N. et al. Differentiation of mesenchymal stem cells under hypoxia and normoxia: lipid profiles revealed by time-of-flight secondary ion mass spectrometry and multivariate analysis. Anal. Chem. \n                           87, 3981\u20133988 (2015).","journal-title":"Anal. Chem."},{"key":"10158_CR16","doi-asserted-by":"publisher","first-page":"20069","DOI":"10.1074\/jbc.M907604199","volume":"275","author":"ML Tiku","year":"2000","unstructured":"Tiku, M. L., Shah, R. & Allison, G. T. Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis. J. Biol. Chem. \n                           275, 20069\u201320076 (2000).","journal-title":"J. Biol. Chem."},{"key":"10158_CR17","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/0026-0495(91)90046-Y","volume":"40","author":"L Lippiello","year":"1991","unstructured":"Lippiello, L., Walsh, T. & Fienhold, M. The association of lipid abnormalities with tissue pathology in human osteoarthritic articular cartilage. Metabolism \n                           40, 571\u2013576 (1991).","journal-title":"Metabolism"},{"key":"10158_CR18","doi-asserted-by":"crossref","unstructured":"Song, P. K. et al. Trends in Determinants of Hypercholesterolemia among Chinese Adults between 2002 and 2012: Results from theNational Nutrition Survey. Nutrients \n                           9 (2017).","DOI":"10.3390\/nu9030279"},{"key":"10158_CR19","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1136\/annrheumdis-2012-202159","volume":"72","author":"DL Riddle","year":"2013","unstructured":"Riddle, D. L., Moxley, G. & Dumenci, L. Associations between statin use and changes in pain, function and structural progression: a longitudinal study of persons with knee osteoarthritis. Ann. Rheum. Dis. \n                           72, 196\u2013203 (2013).","journal-title":"Ann. Rheum. Dis."},{"key":"10158_CR20","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1136\/annrheumdis-2011-200092","volume":"71","author":"S Clockaerts","year":"2012","unstructured":"Clockaerts, S. et al. Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study. Ann. Rheum. Dis. \n                           71, 642\u2013647 (2012).","journal-title":"Ann. Rheum. Dis."},{"key":"10158_CR21","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/ije\/dys053","volume":"42","author":"F Wang","year":"2013","unstructured":"Wang, F. et al. Cohort Profile: the Dongfeng-Tongji cohort study of retired workers. Int. J. Epidemiol. \n                           42, 731\u2013740 (2013).","journal-title":"Int. J. Epidemiol."},{"key":"10158_CR22","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1136\/ard.2005.045724","volume":"66","author":"S Dahaghin","year":"2007","unstructured":"Dahaghin, S., Bierma-Zeinstra, S. M., Koes, B. W., Hazes, J. M. & Pols, H. A. Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study. Ann. Rheum. Dis. \n                           66, 916\u2013920 (2007).","journal-title":"Ann. Rheum. Dis."},{"key":"10158_CR23","first-page":"1827","volume":"25","author":"T Sturmer","year":"1998","unstructured":"Sturmer, T. et al. Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis Study. J. Rheumatol. \n                           25, 1827\u20131832 (1998).","journal-title":"J. Rheumatol."},{"key":"10158_CR24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1161\/CIRCULATIONAHA.106.675355","volume":"116","author":"CS Fox","year":"2007","unstructured":"Fox, C. S. et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation \n                           116, 39\u201348 (2007).","journal-title":"Circulation"},{"key":"10158_CR25","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1126\/science.284.5411.143","volume":"284","author":"MF Pittenger","year":"1999","unstructured":"Pittenger, M. F. et al. Multilineage potential of adult human mesenchymal stem cells. Science \n                           284, 143\u2013147 (1999).","journal-title":"Science"},{"key":"10158_CR26","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1359\/jbmr.1998.13.1.96","volume":"13","author":"DD Diascro Jr.","year":"1998","unstructured":"Diascro, D. D. Jr. et al. High fatty acid content in rabbit serum is responsible for the differentiation of osteoblasts into adipocyte-like cells. J. Bone Miner. Res. \n                           13, 96\u2013106 (1998).","journal-title":"J. Bone Miner. Res."},{"key":"10158_CR27","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/S0140-6736(00)04264-1","volume":"357","author":"RM Aspden","year":"2001","unstructured":"Aspden, R. M., Scheven, B. A. & Hutchison, J. D. Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolism. Lancet \n                           357, 1118\u20131120 (2001).","journal-title":"Lancet"},{"key":"10158_CR28","doi-asserted-by":"publisher","first-page":"4337","DOI":"10.4049\/jimmunol.1300298","volume":"191","author":"RG Snodgrass","year":"2013","unstructured":"Snodgrass, R. G., Huang, S., Choi, I. W., Rutledge, J. C. & Hwang, D. H. Inflammasome-mediated secretion of IL-1beta in human monocytes through TLR2 activation; modulation by dietary fatty acids. J. Immunol. \n                           191, 4337\u20134347 (2013).","journal-title":"J. Immunol."},{"key":"10158_CR29","doi-asserted-by":"publisher","first-page":"3237","DOI":"10.1002\/art.27667","volume":"62","author":"LA Joosten","year":"2010","unstructured":"Joosten, L. A. et al. Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC\/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. Arthritis Rheum. \n                           62, 3237\u20133248 (2010).","journal-title":"Arthritis Rheum."},{"key":"10158_CR30","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1038\/nature08938","volume":"464","author":"P Duewell","year":"2010","unstructured":"Duewell, P. et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature \n                           464, 1357\u20131361 (2010).","journal-title":"Nature"},{"key":"10158_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/ar3689","volume":"14","author":"D Dore","year":"2012","unstructured":"Dore, D. et al. A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee. Arthritis Res. Ther. \n                           14, R13 (2012).","journal-title":"Arthritis Res. Ther."},{"key":"10158_CR32","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1053\/berh.2001.0188","volume":"15","author":"P Ghosh","year":"2001","unstructured":"Ghosh, P. & Cheras, P. A. Vascular mechanisms in osteoarthritis. Best Pract. Res. Clin. Rheumatol. \n                           15, 693\u2013709 (2001).","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10158_CR33","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/BF00541592","volume":"3","author":"JS Dixon","year":"1983","unstructured":"Dixon, J. S. et al. The effect of drugs on serum histidine levels in rheumatoid arthritis. Rheumatol. Int. \n                           3, 145\u2013149 (1983).","journal-title":"Rheumatol. Int."},{"key":"10158_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-015-1122-2","volume":"16","author":"Y Wang","year":"2015","unstructured":"Wang, Y. et al. Does statin use have a disease modifying effect in symptomatic knee osteoarthritis? Study protocol for a randomised controlled trial. Trials \n                           16, 584 (2015).","journal-title":"Trials"},{"key":"10158_CR35","first-page":"93","volume":"1","author":"HA Bird","year":"1983","unstructured":"Bird, H. A. et al. A clinical and biochemical evaluation of Clozic, a novel disease modifying drug in rheumatoid arthritis. Clin. Exp. Rheumatol. \n                           1, 93\u201399 (1983).","journal-title":"Clin. Exp. Rheumatol."},{"key":"10158_CR36","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1136\/ard.16.4.494","volume":"16","author":"JH Kellgren","year":"1957","unstructured":"Kellgren, J. H. & Lawrence, J. S. Radiological assessment of osteo-arthrosis. Ann. Rheum. Dis. \n                           16, 494\u2013502 (1957).","journal-title":"Ann. Rheum. Dis."},{"key":"10158_CR37","unstructured":"Chinese guidelines on prevention and treatment of dyslipidemia in adults. Zhonghua xin xue guan bing za zhi \n                           35, 390\u2013419 (2007)."},{"key":"10158_CR38","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1136\/oem.2006.030148","volume":"64","author":"JC Chen","year":"2007","unstructured":"Chen, J. C., Linnan, L., Callahan, L. F., Yelin, E. H. & Renner, J. B. Workplace policies and prevalence of knee osteoarthritis: the Johnston County Osteoarthritis Project. Occup. Environ. Med. \n                           64, 798\u2013805 (2007).","journal-title":"Occup. Environ. Med."},{"key":"10158_CR39","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/j.joca.2011.03.008","volume":"19","author":"S Muraki","year":"2011","unstructured":"Muraki, S. et al. Association of occupational activity with joint space narrowing and osteophytosis in the medial compartment of the knee: the ROAD study (OAC5914R2). Osteoarthritis Cartilage \n                           19, 840\u2013846 (2011).","journal-title":"Osteoarthritis Cartilage"},{"key":"10158_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/ar3492","volume":"13","author":"LF Callahan","year":"2011","unstructured":"Callahan, L. F. et al. Associations of educational attainment, occupation and community poverty with knee osteoarthritis in the Johnston County (North Carolina) osteoarthritis project. Arthritis Res. Ther. \n                           13, R169 (2011).","journal-title":"Arthritis Res. Ther."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-10158-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-10158-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-10158-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T04:40:59Z","timestamp":1671770459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-10158-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,29]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["10158"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-10158-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,29]]},"assertion":[{"value":"12 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"9739"}}