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Here, we show the role of the cellular prion protein (PrP\n                    <jats:sup>C<\/jats:sup>\n                    ) in mediating the uptake and the spread of recombinant \u03b1-Syn amyloids. The\n                    <jats:italic>in vitro<\/jats:italic>\n                    data revealed that the presence of PrP\n                    <jats:sup>C<\/jats:sup>\n                    fosters the higher uptake of \u03b1-Syn amyloid fibrils, which was also confirmed\n                    <jats:italic>in vivo<\/jats:italic>\n                    in wild type (\n                    <jats:italic>Prnp<\/jats:italic>\n                    <jats:sup>+\/+<\/jats:sup>\n                    ) compared to PrP knock-out (\n                    <jats:italic>Prnp<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice. Additionally, the presence of \u03b1-Syn amyloids blocked the replication of scrapie prions (PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    )\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>ex vivo<\/jats:italic>\n                    , indicating a link between the two proteins. Indeed, whilst PrP\n                    <jats:sup>C<\/jats:sup>\n                    is mediating the internalization of \u03b1-Syn amyloids, PrP\n                    <jats:sup>Sc<\/jats:sup>\n                    is not able to replicate in their presence. This observation has pathological relevance, since several reported case studies show that the accumulation of \u03b1-Syn amyloid deposits in Creutzfeldt-Jakob disease patients is accompanied by a longer disease course.\n                  <\/jats:p>","DOI":"10.1038\/s41598-017-10236-x","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T10:42:22Z","timestamp":1503571342000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":118,"title":["\u03b1-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication"],"prefix":"10.1038","volume":"7","author":[{"given":"Suzana","family":"Auli\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Masperone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Narkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Isopi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Bistaffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ambrosetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Pastore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"De Cecco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Scaini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Zago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Moda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Tagliavini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0716-4393","authenticated-orcid":false,"given":"Giuseppe","family":"Legname","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"10236_CR1","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/nrneurol.2010.145","volume":"6","author":"SJ Lee","year":"2010","unstructured":"Lee, S. 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