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However, its relationship with structural changes in the airways is unknown. We aimed to evaluate the correlation between computer-based airway changes and FeNO in patients with asthma. The wall area (WA) and airway inner luminal area (Ai) of the third- to sixth-generation bronchi were measured using three-dimensional computed tomography in asthmatic patients. Each value was corrected by body surface area (BSA). Relationships between FeNO and WA\/BSA and Ai\/BSA were evaluated. Forty-one clinically stable patients with asthma were evaluated. FeNO was significantly correlated with WA\/BSA of the third-, fourth-, fifth- and sixth-generation bronchi (Spearman correlation coefficient (<jats:italic>\u03c1<\/jats:italic>)\u2009=\u20090.326,<jats:italic>p<\/jats:italic>\u2009=\u20090.041;<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.356,<jats:italic>p<\/jats:italic>\u2009=\u20090.025;<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.496,<jats:italic>p<\/jats:italic>\u2009=\u20090.002; and<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.529,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively). The correlation with sixth-generation bronchi was significantly greater than with the third-generation bronchi (<jats:italic>p<\/jats:italic>\u2009=\u20090.047). Partial rank correlation analysis indicated FeNO was significantly correlated with WA\/BSA of the sixth-generation bronchi, independent from confounding factors of Ai\/BSA, age, duration of asthma, dose of inhaled corticosteroid, blood eosinophil percentage, and blood IgE (<jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.360,<jats:italic>p<\/jats:italic>\u2009=\u20090.034). In contrast, there was no correlation between FeNO and Ai\/BSA. FeNO correlates with bronchial wall thickening in asthma patients. Measurement of FeNO may be useful to detect airway remodeling in asthma.<\/jats:p>","DOI":"10.1038\/s41598-017-10504-w","type":"journal-article","created":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T10:41:02Z","timestamp":1503657662000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma"],"prefix":"10.1038","volume":"7","author":[{"given":"Koji","family":"Nishimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Karayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Inui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironao","family":"Hozumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Furuhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"key":"10504_CR1","unstructured":"Global Initiative for Asthma. 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