{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:57:58Z","timestamp":1793663878448,"version":"4.5.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T00:00:00Z","timestamp":1504483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interleukin-17A (IL-17A) is considered an important pro-inflammatory cytokine but its importance in joint diseases such as rheumatoid arthritis (RA) is unclear. It has also been reported that IL-17A may induce pain but it is unclear whether pro-inflammatory and pro-nociceptive effects are linked. Here we studied in wild type (WT) and IL-17A knockout (IL-17AKO) mice inflammation and hyperalgesia in antigen-induced arthritis (AIA). We found that the severity and time course of AIA were indistinguishable in WT and IL-17AKO mice. Furthermore, the reduction of inflammation by sympathectomy, usually observed in WT mice, was preserved in IL-17AKO mice. Both findings suggest that IL-17A is redundant in AIA pathology. However, in the course of AIA IL-17AKO mice showed less mechanical hyperalgesia than WT mice indicating that IL-17A contributes to pain even if it is not crucial for arthritis pathology. In support for a role of IL-17A and other members of the IL-17 family in the generation of pain we found that sensory neurones in the dorsal root ganglia (DRG) express all IL-17 receptor subtypes. Furthermore, in isolated DRG neurones most IL-17 isoforms increased tetrodotoxin- (TTX-) resistant sodium currents which indicate a role of IL-17 members in inflammation-evoked sensitization of sensory nociceptive neurones.<\/jats:p>","DOI":"10.1038\/s41598-017-10509-5","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T07:04:26Z","timestamp":1503990266000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Interleukin-17A is involved in mechanical hyperalgesia but not in the severity of murine antigen-induced arthritis"],"prefix":"10.1038","volume":"7","author":[{"given":"Matthias","family":"Ebbinghaus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Natura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Segond von Banchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Hensellek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"B\u00f6ttcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas Subhi","family":"Salah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mieczyslaw","family":"Gajda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kamradt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Georg","family":"Schaible","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,4]]},"reference":[{"key":"10509_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S1359-6101(03)00002-9","volume":"14","author":"TA Moseley","year":"2003","unstructured":"Moseley, T. A., Haudenschild, D. R., Rose, L. & Reddi, A. H. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. \n                           14, 155\u2013174 (2003).","journal-title":"Cytokine Growth Factor Rev."},{"key":"10509_CR2","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/nri2586","volume":"9","author":"SL Gaffen","year":"2009","unstructured":"Gaffen, S. L. Structure and signalling in the IL-17 receptor family. Nat. Rev. Immunol. \n                           9, 556\u2013567 (2009).","journal-title":"Nat. Rev. Immunol."},{"key":"10509_CR3","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s10875-010-9369-6","volume":"30","author":"R Pappu","year":"2010","unstructured":"Pappu, R., Ramirez-Carrozzi, V., Ota, N., Ouyang, W. & Hu, Y. The IL-17 family cytokines in immunity and disease. J. Clin. Immunol. \n                           30, 185\u2013195 (2010).","journal-title":"J. Clin. 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Immunity \n                           30, 108\u2013119 (2009).","journal-title":"Immunity"},{"key":"10509_CR7","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1084\/jem.20081463","volume":"206","author":"HR Conti","year":"2009","unstructured":"Conti, H. R. et al. Th17 cells and IL-17 receptor signalling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. \n                           206, 299\u2013311 (2009).","journal-title":"J. Exp. Med."},{"key":"10509_CR8","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.molmed.2016.01.001","volume":"22","author":"A Beringer","year":"2016","unstructured":"Beringer, A., Noack, M. & Miossec, P. IL-17 in chronic inflammation: From discovery to targeting. Trends Mol. Med. \n                           22, 230\u2013241 (2016).","journal-title":"Trends Mol. 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Brief Report: Arthritis in KRN T cell receptor-transgenic mice does not require interleukin-17 or Th17 cells. Arthritis Rheumatol. \n                           68, 1849\u20131855 (2016).","journal-title":"Arthritis Rheumatol."},{"key":"10509_CR18","doi-asserted-by":"publisher","first-page":"329","DOI":"10.4049\/jimmunol.181.1.329","volume":"181","author":"PD Doodes","year":"2008","unstructured":"Doodes, P. D. et al. Development of proteoglycan-induced arthritis is independent of IL-17. J. Immunol. \n                           181, 329\u2013337 (2008).","journal-title":"J. Immunol."},{"key":"10509_CR19","doi-asserted-by":"publisher","first-page":"3783","DOI":"10.1128\/IAI.00385-10","volume":"78","author":"L Henningsson","year":"2010","unstructured":"Henningsson, L. et al. Interleukin-17A during local and systemic Staphylococcus aureus-induced arthritis in mice. Infect. Immun. \n                           78, 3783\u20133790 (2010).","journal-title":"Infect. 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