{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:08:22Z","timestamp":1784819302827,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated bleb fluid images taken after Baerveldt glaucoma implantation. T2-weighted images of bleb fluid were scanned with 3 Tesla magnetic resonance imaging in 52 patients who had undergone tube-shunt surgery using the 350-mm<jats:sup>2<\/jats:sup> endplate Baerveldt glaucoma implant; three-dimensional images were constructed from these images. Bleb fluid images were classified into either a layer of bleb fluid on either side of the endplate (double bleb layer group; n\u2009=\u200924) or one layer outside the endplate (single bleb layer group; n\u2009=\u200928). Despite there being no correlation between the bleb volume and the postoperative IOP (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.080; <jats:italic>P<\/jats:italic>\u2009=\u20090.57), the double bleb layer group had significantly lower postoperative IOPs than the single bleb layer group (12.3\u2009\u00b1\u20093.8\u2009mmHg vs. 14.7\u2009\u00b1\u20094.1\u2009mmHg, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.033). The single bleb layer was significantly related to higher numbers of prior intraocular surgeries (relative risk\u2009=\u20092.85; <jats:italic>P<\/jats:italic>\u2009=\u20090.0014). Formation of a layer of bleb fluid on either side of the endplate may have resulted in the lower postoperative IOPs after Baerveldt glaucoma implantation. Repeated intraocular surgery adversely affects formation of the double bleb layer.<\/jats:p>","DOI":"10.1038\/s41598-017-11054-x","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T22:06:24Z","timestamp":1504735584000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Evaluation of Bleb Fluid After Baerveldt Glaucoma Implantation Using Magnetic Resonance Imaging"],"prefix":"10.1038","volume":"7","author":[{"given":"Kentaro","family":"Iwasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Kanamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Takihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Arimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Takamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Inatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"11054_CR1","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1016\/j.ophtha.2015.04.015","volume":"122","author":"KS Arora","year":"2015","unstructured":"Arora, K. S., Robin, A. L., Corcoran, K. J., Corcoran, S. L. & Ramulu, P. Y. Use of various glaucoma surgeries and procedures in medicare beneficiaries from 1994 to 2012. Ophthalmology \n                           122, 1615\u20131624 (2015).","journal-title":"Ophthalmology"},{"key":"11054_CR2","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.ajo.2011.10.026","volume":"153","author":"SJ Gedde","year":"2012","unstructured":"Gedde, S. J. et al. Treatment outcomes in the tube versus trabeculectomy (TVT) study after five years of follow-up. Am J Ophthalmol \n                           153, 789\u2013803 (2012).","journal-title":"Am J Ophthalmol"},{"key":"11054_CR3","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.ajo.2005.11.039","volume":"141","author":"H Fontana","year":"2006","unstructured":"Fontana, H., Nouri-Mahdavi, K. & Caprioli, J. Trabeculectomy with mitomycin C in pseudophakic patients with open-angle glaucoma: outcomes and risk factors for failure. 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J Glaucoma \n                           18, 453\u2013459 (2009).","journal-title":"J Glaucoma"},{"key":"11054_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144595","volume":"10","author":"I Sano","year":"2015","unstructured":"Sano, I. et al. Assessment of filtration bleb and endplate positioning using magnetic resonance imaging in eyes implanted with long-tube glaucoma drainage devices. PloS one \n                           10, e0144595 (2015).","journal-title":"PloS one"},{"key":"11054_CR9","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1016\/S0161-6420(92)31772-5","volume":"99","author":"DK Heuer","year":"1992","unstructured":"Heuer, D. K., Lloyd, M. A. & Abrams, D. A. et al. Which is better? One or two? A randomized clinical trial of single-plate versus double-plate molteno implantation for glaucomas in aphakia and pseudophakia. 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J Curr Glaucoma Pract \n                           9, 1\u20135 (2015).","journal-title":"J Curr Glaucoma Pract"},{"key":"11054_CR16","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1109\/TSMC.1979.4310076","volume":"9","author":"N Otsu","year":"1979","unstructured":"Otsu, N. A threshold selection method from gray-level histograms. IEEE Trans Syst Man Cybern \n                           9, 62\u201366 (1979).","journal-title":"IEEE Trans Syst Man Cybern"},{"key":"11054_CR17","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.ajo.2005.03.031","volume":"140","author":"SJ Gedde","year":"2005","unstructured":"Gedde, S. J. et al. The tube versus trabeculectomy study: design and baseline characteristics of study patients. 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Acta ophthalmologica \n                           94, e541\u2013e549 (2016).","journal-title":"Acta ophthalmologica"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11054-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11054-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11054-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T10:42:05Z","timestamp":1671792125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11054-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,12]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["11054"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-11054-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,12]]},"assertion":[{"value":"24 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M.I. is responsible for submitting a competing financial interest statement on behalf of all authors of the paper. M.I.\u2019s work has been partially funded by HOYA, Novartis, Pfizer, Alcon, Senju, Santen, Kowa, Otsuka, NIDEK, Wakamoto, and AMO. The other authors declare no potential conflict.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"11345"}}