{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:13:06Z","timestamp":1783573986104,"version":"3.55.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T00:00:00Z","timestamp":1504828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extinction is a process that involves new learning that inhibits the expression of previously acquired memories. Although temporarily effective, extinction does not erase an original fear association. Since the extinction trace tends to fade over time, the original memory can resurge. On the other hand, strengthening effects have been described in several reconsolidation studies using different behavioral and pharmacological manipulations. In order to know whether an extinction memory can be strengthened by reactivation-based interventions in the contextual fear conditioning task, we began by replicating the classic phenomenon of spontaneous recovery to show that brief reexposure sessions can prevent the decay of the extinction trace over time in a long-lasting way. This fear attenuation was shown to depend both on L-type calcium channels and protein synthesis, which suggests a reconsolidation process behind the reactivation-induced strengthening effect. The extinction trace was also susceptible to enhancement by a post-reactivation infusion of a memory-enhancing drug (NaB), which was also able to prevent rapid fear reacquisition (savings). These findings point to new reactivation-based approaches able to strengthen an extinction memory to promote its persistence. The constructive interactions between extinction and reconsolidation may represent a promising novel approach in the realm of fear-related disorder treatments.<\/jats:p>","DOI":"10.1038\/s41598-017-11261-6","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T09:43:41Z","timestamp":1504518221000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Enhancement of extinction memory by pharmacological and behavioral interventions targeted to its reactivation"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3632-5566","authenticated-orcid":false,"given":"Josu\u00e9","family":"Haubrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Zacouteguy","family":"Boos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P.","family":"Crestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo O.","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-903X","authenticated-orcid":false,"given":"Lucas de Oliveira","family":"Alvares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Quillfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,8]]},"reference":[{"key":"11261_CR1","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/35021052","volume":"406","author":"K Nader","year":"2000","unstructured":"Nader, K., Schafe, G. E. & Le Doux, J. E. Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature \n                           406, 722\u20136 (2000).","journal-title":"Nature"},{"key":"11261_CR2","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/npp.2009.121","volume":"35","author":"CA Hartley","year":"2010","unstructured":"Hartley, C. A. & Phelps, E. A. Changing fear: the neurocircuitry of emotion regulation. Neuropsychopharmacology \n                           35, 136\u201346 (2010).","journal-title":"Neuropsychopharmacology"},{"key":"11261_CR3","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.neubiorev.2012.03.008","volume":"36","author":"PSB Finnie","year":"2012","unstructured":"Finnie, P. S. B. & Nader, K. The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidation. Neurosci. Biobehav. Rev. \n                           36, 1667\u2013707 (2012).","journal-title":"Neurosci. Biobehav. Rev."},{"key":"11261_CR4","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/nrn2090","volume":"8","author":"NC Tronson","year":"2007","unstructured":"Tronson, N. C. & Taylor, J. R. Molecular mechanisms of memory reconsolidation. Nat. Rev. Neurosci. \n                           8, 262\u201375 (2007).","journal-title":"Nat. Rev. Neurosci."},{"key":"11261_CR5","doi-asserted-by":"publisher","first-page":"21801","DOI":"10.1073\/pnas.1016254107","volume":"107","author":"JI Rossato","year":"2010","unstructured":"Rossato, J. I., Bevilaqua, L. R., Izquierdo, I., Medina, J. H. & Cammarota, M. Retrieval induces reconsolidation of fear extinction memory. Proc. Natl. Acad. Sci. USA \n                           107, 21801\u201321805 (2010).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"11261_CR6","doi-asserted-by":"publisher","first-page":"6570","DOI":"10.1523\/JNEUROSCI.4093-14.2015","volume":"35","author":"A Radiske","year":"2015","unstructured":"Radiske, A. et al. Requirement for BDNF in the reconsolidation of fear extinction. J Neurosci \n                           35, 6570\u20136574 (2015).","journal-title":"J Neurosci"},{"key":"11261_CR7","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1111\/j.1460-9568.2004.03818.x","volume":"20","author":"M Eisenberg","year":"2004","unstructured":"Eisenberg, M. & Dudai, Y. Reconsolidation of fresh, remote, and extinguished fear memory in Medaka: old fears don\u2019t die. Eur J Neurosci \n                           20, 3397\u20133403 (2004).","journal-title":"Eur J Neurosci"},{"key":"11261_CR8","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1038\/mp.2015.136","volume":"20","author":"L Rosas-Vidal","year":"2015","unstructured":"Rosas-Vidal, L., Rodriguez-Romaguera, J., Do-Monte, F. & Andero, R. Targeting the reconsolidation of extinction memories: a novel potential strategy to treat anxiety disorders. Mol. Psychiatry \n                           20, 1264\u20131265 (2015).","journal-title":"Mol. Psychiatry"},{"key":"11261_CR9","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.biopsych.2005.12.015","volume":"60","author":"ME Bouton","year":"2006","unstructured":"Bouton, M. E., Westbrook, R. F., Corcoran, K. A. & Maren, S. Contextual and temporal modulation of extinction: behavioral and biological mechanisms. Biol. Psychiatry \n                           60, 352\u201360 (2006).","journal-title":"Biol. Psychiatry"},{"key":"11261_CR10","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/sj.npp.1301555","volume":"33","author":"GJ Quirk","year":"2008","unstructured":"Quirk, G. J. & Mueller, D. Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology \n                           33, 56\u201372 (2008).","journal-title":"Neuropsychopharmacology"},{"key":"11261_CR11","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.neubiorev.2014.10.016","volume":"47","author":"C Furini","year":"2014","unstructured":"Furini, C., Myskiw, J. & Izquierdo, I. The learning of fear extinction. Neurosci. Biobehav. Rev. \n                           47, 670\u2013683 (2014).","journal-title":"Neurosci. Biobehav. Rev."},{"key":"11261_CR12","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.cpr.2009.09.001","volume":"29","author":"J Cukor","year":"2009","unstructured":"Cukor, J., Spitalnick, J., Difede, J., Rizzo, A. & Rothbaum, B. O. Emerging treatments for PTSD. Clin. Psychol. Rev. \n                           29, 715\u201326 (2009).","journal-title":"Clin. Psychol. Rev."},{"key":"11261_CR13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1146\/annurev-clinpsy-050212-185542","volume":"9","author":"B Vervliet","year":"2013","unstructured":"Vervliet, B., Craske, M. G. & Hermans, D. Fear extinction and relapse: state of the art. Annu. Rev. Clin. Psychol. \n                           9, 215\u201348 (2013).","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"11261_CR14","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/S0006-3223(02)01546-9","volume":"52","author":"ME Bouton","year":"2002","unstructured":"Bouton, M. E. Context, ambiguity, and unlearning: Sources of relapse after behavioral extinction. Biological Psychiatry \n                           52, 976\u2013986 (2002).","journal-title":"Biological Psychiatry"},{"key":"11261_CR15","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1101\/lm.77504","volume":"11","author":"Ra Rescorla","year":"2004","unstructured":"Rescorla, Ra Spontaneous recovery. Learn. Mem. \n                           11, 501\u20139 (2004).","journal-title":"Learn. Mem."},{"key":"11261_CR16","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/nrn2590","volume":"10","author":"K Nader","year":"2009","unstructured":"Nader, K. & Hardt, O. A single standard for memory: the case for reconsolidation. Nat Rev Neurosci \n                           10, 224\u2013234 (2009).","journal-title":"Nat Rev Neurosci"},{"key":"11261_CR17","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/S0896-6273(03)00352-0","volume":"38","author":"ME Pedreira","year":"2003","unstructured":"Pedreira, M. E. & Maldonado, H. Protein synthesis subserves reconsolidation or extinction depending on reminder duration. Neuron \n                           38, 863\u2013869 (2003).","journal-title":"Neuron"},{"key":"11261_CR18","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/npp.2008.75","volume":"34","author":"SG Bustos","year":"2009","unstructured":"Bustos, S. G., Maldonado, H. & Molina, V. A. Disruptive effect of midazolam on fear memory reconsolidation: decisive influence of reactivation time span and memory age. Neuropsychopharmacology \n                           34, 446\u201357 (2009).","journal-title":"Neuropsychopharmacology"},{"key":"11261_CR19","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1523\/JNEUROSCI.4001-13.2014","volume":"34","author":"E Merlo","year":"2014","unstructured":"Merlo, E., Milton, A. L., Gooz\u00e9e, Z. Y., Theobald, D. E. & Everitt, B. J. Reconsolidation and extinction are dissociable and mutually exclusive processes: behavioral and molecular evidence. J. Neurosci. \n                           34, 2422\u201331 (2014).","journal-title":"J. Neurosci."},{"key":"11261_CR20","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1126\/science.1086881","volume":"301","author":"M Eisenberg","year":"2003","unstructured":"Eisenberg, M., Kobilo, T., Berman, D. E. & Dudai, Y. Stability of retrieved memory: inverse correlation with trace dominance. Science \n                           301, 1102\u20131104 (2003).","journal-title":"Science"},{"key":"11261_CR21","doi-asserted-by":"publisher","first-page":"4787","DOI":"10.1523\/JNEUROSCI.5491-03.2004","volume":"24","author":"A Suzuki","year":"2004","unstructured":"Suzuki, A. et al. Memory reconsolidation and extinction have distinct temporal and biochemical signatures. J. Neurosci. \n                           24, 4787\u201395 (2004).","journal-title":"J. Neurosci."},{"key":"11261_CR22","doi-asserted-by":"publisher","first-page":"10051","DOI":"10.1523\/JNEUROSCI.2466-06.2006","volume":"26","author":"JLC Lee","year":"2006","unstructured":"Lee, J. L. C., Milton, A. L. & Everitt, B. J. Reconsolidation and extinction of conditioned fear: inhibition and potentiation. J. Neurosci. \n                           26, 10051\u20136 (2006).","journal-title":"J. Neurosci."},{"key":"11261_CR23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.nlm.2013.04.009","volume":"104","author":"CR Flavell","year":"2013","unstructured":"Flavell, C. R. & Lee, J. L. Reconsolidation and extinction of an appetitive pavlovian memory. Neurobiol Learn Mem \n                           104, 25\u201331 (2013).","journal-title":"Neurobiol Learn Mem"},{"key":"11261_CR24","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.nlm.2014.08.015","volume":"115","author":"V Tedesco","year":"2014","unstructured":"Tedesco, V., Roquet, R. F., DeMis, J., Chiamulera, C. & Monfils, M.-H. Extinction, applied after retrieval of auditory fear memory, selectively increases zinc-finger protein 268 and phosphorylated ribosomal protein S6 expression in prefrontal cortex and lateral amygdala. Neurobiol. Learn. Mem. \n                           115, 78\u201385 (2014).","journal-title":"Neurobiol. Learn. Mem."},{"key":"11261_CR25","doi-asserted-by":"publisher","first-page":"5562","DOI":"10.1523\/JNEUROSCI.6066-10.2011","volume":"31","author":"V de la Fuente","year":"2011","unstructured":"de la Fuente, V., Freudenthal, R. & Romano, A. Reconsolidation or extinction: transcription factor switch in the determination of memory course after retrieval. J. Neurosci. \n                           31, 5562\u201373 (2011).","journal-title":"J. Neurosci."},{"key":"11261_CR26","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1101\/lm.1877010","volume":"17","author":"A Kirtley","year":"2010","unstructured":"Kirtley, A. & Thomas, K. L. The exclusive induction of extinction is gated by BDNF. Learn. Mem. \n                           17, 612\u2013619 (2010).","journal-title":"Learn. Mem."},{"key":"11261_CR27","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.tins.2009.05.002","volume":"32","author":"JLC Lee","year":"2009","unstructured":"Lee, J. L. C. Reconsolidation: maintaining memory relevance. Trends Neurosci. \n                           32, 413\u201320 (2009).","journal-title":"Trends Neurosci."},{"key":"11261_CR28","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.pneurobio.2012.07.002","volume":"99","author":"A Besnard","year":"2012","unstructured":"Besnard, A., Caboche, J. & Laroche, S. Reconsolidation of memory: a decade of debate. Prog. Neurobiol. \n                           99, 61\u201380 (2012).","journal-title":"Prog. Neurobiol."},{"key":"11261_CR29","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/npp.2010.169","volume":"36","author":"L Nadel","year":"2011","unstructured":"Nadel, L. & Hardt, O. Update on memory systems and processes. Neuropsychopharmacology \n                           36, 251\u201373 (2011).","journal-title":"Neuropsychopharmacology"},{"key":"11261_CR30","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuroscience.2013.04.005","volume":"244","author":"L De Oliveira Alvares","year":"2013","unstructured":"De Oliveira Alvares, L. et al. Reactivation enables memory updating, precision-keeping and strengthening: Exploring the possible biological roles of reconsolidation. Neuroscience \n                           244, 42\u201348 (2013).","journal-title":"Neuroscience"},{"key":"11261_CR31","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.nlm.2009.08.006","volume":"93","author":"C Forcato","year":"2010","unstructured":"Forcato, C., Rodr\u00edguez, M. L. C., Pedreira, M. E. & Maldonado, H. Reconsolidation in humans opens up declarative memory to the entrance of new information. Neurobiol. Learn. Mem. \n                           93, 77\u201384 (2010).","journal-title":"Neurobiol. Learn. Mem."},{"key":"11261_CR32","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1126\/science.1167975","volume":"324","author":"M-H Monfils","year":"2009","unstructured":"Monfils, M.-H., Cowansage, K. K., Klann, E. & LeDoux, J. E. Extinction-reconsolidation boundaries: key to persistent attenuation of fear memories. Science (80-.). \n                           324, 951\u2013955 (2009).","journal-title":"Science (80-.)."},{"key":"11261_CR33","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1101\/lm.365707","volume":"14","author":"A Hupbach","year":"2007","unstructured":"Hupbach, A., Gomez, R., Hardt, O. & Nadel, L. Reconsolidation of episodic memories: a subtle reminder triggers integration of new information. Learn. Mem. \n                           14, 47\u201353 (2007).","journal-title":"Learn. Mem."},{"key":"11261_CR34","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/npp.2014.174","volume":"40","author":"J Haubrich","year":"2015","unstructured":"Haubrich, J. et al. Reconsolidation allows fear memory to be updated to a less aversive level through the incorporation of appetitive information. Neuropsychopharmacology \n                           40, 315\u2013326 (2015).","journal-title":"Neuropsychopharmacology"},{"key":"11261_CR35","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1523\/JNEUROSCI.4736-10.2011","volume":"31","author":"MC Inda","year":"2011","unstructured":"Inda, M. C., Muravieva, E. V. & Alberini, C. M. Memory retrieval and the passage of time: from reconsolidation and strengthening to extinction. J. Neurosci. \n                           31, 1635\u201343 (2011).","journal-title":"J. Neurosci."},{"key":"11261_CR36","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1038\/nn.2205","volume":"11","author":"JLC Lee","year":"2008","unstructured":"Lee, J. L. C. Memory reconsolidation mediates the strengthening of memories by additional learning. Nat. Neurosci. \n                           11, 1264\u20136 (2008).","journal-title":"Nat. Neurosci."},{"key":"11261_CR37","first-page":"1","volume":"2014","author":"H Fukushima","year":"2014","unstructured":"Fukushima, H. et al. Enhancement of fear memory by retrieval through reconsolidation. Elife \n                           2014, 1\u201319 (2014).","journal-title":"Elife"},{"key":"11261_CR38","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1007\/s00702-013-1032-y","volume":"120","author":"TR Pedroso","year":"2013","unstructured":"Pedroso, T. R. et al. Inhibition of protein synthesis or mTOR in the basolateral amygdala blocks retrieval-induced memory strengthening. J. Neural Transm. \n                           120, 1525\u20131531 (2013).","journal-title":"J. Neural Transm."},{"key":"11261_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023305","volume":"6","author":"C Forcato","year":"2011","unstructured":"Forcato, C., Rodr\u00edguez, M. L. C. & Pedreira, M. E. Repeated labilization-reconsolidation processes strengthen declarative memory in humans. PLoS One \n                           6, e23305 (2011).","journal-title":"PLoS One"},{"key":"11261_CR40","doi-asserted-by":"crossref","unstructured":"Crestani, A. P. et al. Memory reconsolidation may be disrupted by a distractor stimulus presented during reactivation. Sci. Rep. 5 (2015).","DOI":"10.1038\/srep13633"},{"key":"11261_CR41","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1101\/lm.1356509","volume":"16","author":"P Garcia-DeLaTorre","year":"2009","unstructured":"Garcia-DeLaTorre, P., Rodriguez-Ortiz, C. J., Arreguin-Martinez, J. L., Cruz-Castaneda, P. & Bermudez-Rattoni, F. Simultaneous but not independent anisomycin infusions in insular cortex and amygdala hinder stabilization of taste memory when updated. Learn. Mem. \n                           16, 514\u2013519 (2009).","journal-title":"Learn. Mem."},{"key":"11261_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2010.00168","volume":"4","author":"JLC Lee","year":"2010","unstructured":"Lee, J. L. C. Memory reconsolidation mediates the updating of hippocampal memory content. Front. Behav. Neurosci. \n                           4, 168 (2010).","journal-title":"Front. Behav. Neurosci."},{"key":"11261_CR43","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.neuron.2006.04.012","volume":"50","author":"RGM Morris","year":"2006","unstructured":"Morris, R. G. M. et al. Memory reconsolidation: sensitivity of spatial memory to inhibition of protein synthesis in dorsal hippocampus during encoding and retrieval. Neuron \n                           50, 479\u201389 (2006).","journal-title":"Neuron"},{"key":"11261_CR44","doi-asserted-by":"publisher","unstructured":"Soeter, M. & Kindt, M. An Abrupt Transformation of Phobic Behavior After a Post-Retrieval Amnesic Agent. Biol Psychiatry, doi:10.1016\/j.biopsych.2015.04.006 (2015).","DOI":"10.1016\/j.biopsych.2015.04.006"},{"key":"11261_CR45","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1101\/lm.801108","volume":"15","author":"TW Bredy","year":"2008","unstructured":"Bredy, T. W. & Barad, M. The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear. Learn. Mem. \n                           15, 39\u201345 (2008).","journal-title":"Learn. Mem."},{"key":"11261_CR46","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/wsbm.1196","volume":"5","author":"SA Stern","year":"2013","unstructured":"Stern, S. A. & Alberini, C. M. Mechanisms of memory enhancement. Wiley Interdiscip Rev Syst Biol Med \n                           5, 37\u201353 (2013).","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"11261_CR47","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/nn1628","volume":"9","author":"NC Tronson","year":"2006","unstructured":"Tronson, N. C., Wiseman, S. L., Olausson, P. & Taylor, J. R. Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A. Nat. Neurosci. \n                           9, 167\u20139 (2006).","journal-title":"Nat. Neurosci."},{"key":"11261_CR48","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.brainresbull.2013.12.007","volume":"105","author":"PJ Fitzgerald","year":"2014","unstructured":"Fitzgerald, P. J., Seemann, J. R. & Maren, S. Can fear extinction be enhanced? A review of pharmacological and behavioral findings. Brain Res. Bull. \n                           105, 46\u201360 (2014).","journal-title":"Brain Res. Bull."},{"key":"11261_CR49","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.beproc.2012.03.004","volume":"90","author":"ME Bouton","year":"2012","unstructured":"Bouton, M. E., Winterbauer, N. E. & Todd, T. P. Relapse processes after the extinction of instrumental learning: renewal, resurgence, and reacquisition. Behav. Processes \n                           90, 130\u201341 (2012).","journal-title":"Behav. Processes"},{"key":"11261_CR50","doi-asserted-by":"publisher","unstructured":"Gr\u00e4ff, J., Kim, D., Dobbin, M. M. & Tsai, L. Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes. 603\u2013649, doi:10.1152\/physrev.00012.2010 (2011).","DOI":"10.1152\/physrev.00012.2010"},{"key":"11261_CR51","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1101\/lm.888808","volume":"15","author":"A Suzuki","year":"2008","unstructured":"Suzuki, A., Mukawa, T., Tsukagoshi, A., Frankland, P. W. & Kida, S. Activation of LVGCCs and CB1 receptors required for destabilization of reactivated contextual fear memories. Learn. Mem. \n                           15, 426\u201333 (2008).","journal-title":"Learn. Mem."},{"key":"11261_CR52","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.neuroscience.2012.05.057","volume":"219","author":"N Federman","year":"2012","unstructured":"Federman, N., Fustinana, M. S. & Romano, A. Reconsolidation involves histone acetylation depending on the strength of the memory. Neuroscience \n                           219, 145\u2013156 (2012).","journal-title":"Neuroscience"},{"key":"11261_CR53","doi-asserted-by":"publisher","DOI":"10.1038\/srep27015","volume":"6","author":"H Villain","year":"2016","unstructured":"Villain, H., Florian, C. & Roullet, P. HDAC inhibition promotes both initial consolidation and reconsolidation of spatial memory in mice. Sci. Rep. \n                           6, 27015 (2016).","journal-title":"Sci. Rep."},{"key":"11261_CR54","doi-asserted-by":"publisher","first-page":"9447","DOI":"10.1073\/pnas.0903964106","volume":"106","author":"DP Stefanko","year":"2009","unstructured":"Stefanko, D. P., Barrett, R. M., Ly, A. R., Reolon, G. K. & Wood, M. A. Modulation of long-term memory for object recognition via HDAC inhibition. Proc. Natl. Acad. Sci. USA. \n                           106, 9447\u201352 (2009).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"11261_CR55","doi-asserted-by":"crossref","unstructured":"Pavlov, I. P. Conditioned reflexes: An investigation of the physiological activity of the cerebral cortex. Book 17 (1927).","DOI":"10.5214\/ans.0972-7531.1017309"},{"key":"11261_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1515","volume":"2","author":"CR Flavell","year":"2011","unstructured":"Flavell, C. R., Barber, D. J. & Lee, J. L. C. Behavioural memory reconsolidation of food and fear memories. Nat. Commun. \n                           2, 504 (2011).","journal-title":"Nat. Commun."},{"key":"11261_CR57","doi-asserted-by":"crossref","first-page":"9113","DOI":"10.1523\/JNEUROSCI.22-20-09113.2002","volume":"22","author":"CK Cain","year":"2002","unstructured":"Cain, C. K., Blouin, A. M. & Barad, M. L-Type Voltage-Gated Calcium Channels Are Required for Extinction, But Not for Acquisition or Expression, of Conditional Fear in Mice. J. Neurosci. \n                           22, 9113\u20139121 (2002).","journal-title":"J. Neurosci."},{"key":"11261_CR58","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.jphysparis.2014.08.006","volume":"108","author":"S Almeida-Correa","year":"2014","unstructured":"Almeida-Correa, S. & Amaral, O. B. Memory labilization in reconsolidation and extinction\u2013evidence for a common plasticity system? J Physiol Paris \n                           108, 292\u2013306 (2014).","journal-title":"J Physiol Paris"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11261-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11261-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11261-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T10:41:42Z","timestamp":1671792102000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11261-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,8]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["11261"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-11261-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,8]]},"assertion":[{"value":"18 April 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"10960"}}