{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:04:05Z","timestamp":1790186645866,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical data from 172 cases of uterine fibroids with different appearances on MRI-T2WI and accepted ultrasound guided high intensity focused ultrasound (USgHIFU) treatment were retrospectively analyzed. This study aimed to evaluate the clinical safety and efficacy of ablating different types of fibroids, classified by T2-weighted magnetic resonance imaging (MRI-T2WI). Based on MRI-T2WI signal intensities, uterine fibroids were classified as three types: hypointensive (52 cases), isointensive (64 cases) and hyperintensive (56 cases). Evaluation parameters including treatment time, ablation efficiency, percentage non-perfused volume, fibroid reduction rate, adverse reactions, symptom severity scores (SSS) and re-intervention rate were assessed from 3 months to 1 year. The percentage non-perfused volume and ablation efficiency of hyperintensive uterine fibroids were lower than those of isointensive and hypointensive uterine fibroids. All fibroids shrunk and the SSS continued to reduce at 3 and 6 months after treatment respectively. At 12-month postoperative assessments, hypointensive fibroids continued to shrink, while the isointensive fibroids enlarged but remained smaller than pre-treatment. The incident rate of postoperative Society of Interventional Radiology B-class (SIRB-class) adverse events showed no significant differences. The re-interventional rate of hyperintensive fibroids was higher than in isointensive and hypointensive groups. USgHIFU ablation of all types of fibroids were safe and effective.<\/jats:p>","DOI":"10.1038\/s41598-017-11486-5","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T10:18:35Z","timestamp":1504261115000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A clinical investigation treating different types of fibroids identified by MRI-T2WI imaging with ultrasound guided high intensity focused ultrasound"],"prefix":"10.1038","volume":"7","author":[{"given":"Wen-Peng","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Peng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,7]]},"reference":[{"key":"11486_CR1","first-page":"424","volume":"9","author":"R Sparic","year":"2016","unstructured":"Sparic, R., Mirkovic, L., Malvasi, A. & Tinelli, A. Epidemiology of Uterine Myomas: A Review. International journal of fertility & sterility \n                           9, 424\u2013435 (2016).","journal-title":"International journal of fertility & sterility"},{"key":"11486_CR2","first-page":"1011","volume":"36","author":"J Kacperczyk","year":"2016","unstructured":"Kacperczyk, J., Bartnik, P., Romejko-Wolniewicz, E. & Dobrowolska-Redo, A. Postmyomectomic Uterine Rupture Despite Cesarean Section. Anticancer Res \n                           36, 1011\u20131013 (2016).","journal-title":"Anticancer Res"},{"key":"11486_CR3","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.ijgo.2015.07.005","volume":"132","author":"J Liu","year":"2016","unstructured":"Liu, J. et al. T2-weighted imaging in the assessment of the non-perfused volume of uterine fibroids following magnetic resonance-guided high-intensity focused ultrasound ablation. Int J Gynaecol Obstet \n                           132, 100\u2013102 (2016).","journal-title":"Int J Gynaecol Obstet"},{"key":"11486_CR4","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/j.1471-0528.2007.01657.x","volume":"115","author":"H Zowall","year":"2008","unstructured":"Zowall, H. et al. Cost-effectiveness of magnetic resonance-guided focused ultrasound surgery for treatment of uterine fibroids. BJOG: an international journal of obstetrics and gynaecology \n                           115, 653\u2013662 (2008).","journal-title":"BJOG: an international journal of obstetrics and gynaecology"},{"key":"11486_CR5","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1002\/uog.4099","volume":"30","author":"J Rabinovici","year":"2007","unstructured":"Rabinovici, J. et al. Clinical improvement and shrinkage of uterine fibroids after thermal ablation by magnetic resonance-guided focused ultrasound surgery. Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology \n                           30, 771\u2013777 (2007).","journal-title":"Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology"},{"key":"11486_CR6","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.2214\/ajr.183.6.01831713","volume":"183","author":"J Hindley","year":"2004","unstructured":"Hindley, J. et al. MRI guidance of focused ultrasound therapy of uterine fibroids: early results. AJR American journal of roentgenology \n                           183, 1713\u20131719 (2004).","journal-title":"AJR American journal of roentgenology"},{"key":"11486_CR7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1067\/mob.2003.345","volume":"189","author":"EA Stewart","year":"2003","unstructured":"Stewart, E. A. et al. Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative technique. Am J Obstet Gynecol \n                           189, 48\u201354 (2003).","journal-title":"Am J Obstet Gynecol"},{"key":"11486_CR8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/GCO.0000000000000070","volume":"26","author":"NA Clark","year":"2014","unstructured":"Clark, N. A., Mumford, S. L. & Segars, J. H. Reproductive impact of MRI-guided focused ultrasound surgery for fibroids: a systematic review of the evidence. Curr Opin Obstet Gynecol \n                           26, 151\u2013161 (2014).","journal-title":"Curr Opin Obstet Gynecol"},{"key":"11486_CR9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1097\/01.AOG.0000275283.39475.f6","volume":"110","author":"EA Stewart","year":"2007","unstructured":"Stewart, E. A. et al. Tempany CM. Sustained relief of leiomyoma symptoms by using focused ultrasound surgery. Obstet Gynecol \n                           110, 279\u2013287 (2007).","journal-title":"Obstet Gynecol"},{"key":"11486_CR10","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1002\/uog.7455","volume":"34","author":"K Funaki","year":"2009","unstructured":"Funaki, K., Fukunishi, H. & Sawada, K. Clinical outcomes of magnetic resonance-guided focused ultrasound surgery for uterine myomas: 24-month follow-up. Ultrasound Obstet Gynecol \n                           34, 584\u2013589 (2009).","journal-title":"Ultrasound Obstet Gynecol"},{"key":"11486_CR11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1148\/radiol.2491071600","volume":"249","author":"ZM Lenard","year":"2008","unstructured":"Lenard, Z. M. et al. Uterine leiomyomas: MR imaging-guided focused ultrasound surgery\u2013imaging predictors of success. Radiology \n                           249, 187\u2013194 (2008).","journal-title":"Radiology"},{"key":"11486_CR12","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.ejrad.2014.11.041","volume":"84","author":"WP Zhao","year":"2015","unstructured":"Zhao, W. P., Han, Z. Y., Zhang, J. & Liang, P. A retrospective comparison of microwave ablation and high intensity focused ultrasound for treating symptomatic uterine fibroids. European journal of radiology \n                           84, 413\u2013417 (2015).","journal-title":"European journal of radiology"},{"key":"11486_CR13","doi-asserted-by":"publisher","first-page":"e43","DOI":"10.1016\/j.ejrad.2012.08.020","volume":"82","author":"WP Zhao","year":"2013","unstructured":"Zhao, W. P. et al. Feasibility of ultrasound-guided high intensity focused ultrasound ablating uterine fibroids with hyperintensive on T2-weighted MR imaging. European journal of radiology \n                           82, e43\u201349 (2013).","journal-title":"European journal of radiology"},{"key":"11486_CR14","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1007\/s11604-007-0215-6","volume":"26","author":"K Mikami","year":"2008","unstructured":"Mikami, K. et al. Magnetic resonance imaging-guided focused ultrasound ablation of uterine fibroids: early clinical experience. Radiation medicine \n                           26, 198\u2013205 (2008).","journal-title":"Radiation medicine"},{"key":"11486_CR15","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.jmig.2007.04.009","volume":"14","author":"K Funaki","year":"2007","unstructured":"Funaki, K., Fukunishi, H., Funaki, T. & Kawakami, C. Mid-term outcome of magnetic resonance-guided focused ultrasound surgery for uterine myomas: from six to twelve months after volume reduction. 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Eur J Obstet Gynecol Reprod Biol \n                           139, 199\u2013203 (2008).","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"11486_CR18","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.ultrasmedbio.2014.09.022","volume":"41","author":"WP Zhao","year":"2015","unstructured":"Zhao, W. P., Chen, J. Y. & Chen, W. Z. Effect of biological characteristics of different types of uterine fibroids, as assessed with T2-weighted magnetic resonance imaging, on ultrasound-guided high-intensity focused ultrasound ablation. Ultrasound in medicine & biology \n                           41, 423\u2013431 (2015).","journal-title":"Ultrasound in medicine & biology"},{"key":"11486_CR19","first-page":"303","volume":"21","author":"J Yan","year":"2012","unstructured":"Yan, J., Zhuang, T. & Shou, W. The development and application of high intensity focused ultrasound. 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Analysis of complications of high intensity focused ultrasound in treatment of uterine leiomyoma. Zhonghua Fu Chan Ke Za Zhi \n                           45, 913\u2013916 (2010).","journal-title":"Zhonghua Fu Chan Ke Za Zhi"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11486-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11486-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11486-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T10:43:52Z","timestamp":1671792232000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11486-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,7]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["11486"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-11486-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,7]]},"assertion":[{"value":"15 June 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"10812"}}