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Diffusion MRI was acquired using a Siemens 3 Tesla Prisma scanner with 80\u2009mT\/m gradients and a 32-channel head coil from each of 3 concussive traumatic brain injury (cTBI) patients and 4 controls twice 0 to 24 days apart. Coefficients of variation (CoV) for DTI parameters were calculated in each DTI Studio parcellated white matter tract at 1.25\u2009mm and 1.75\u2009mm isotropic voxel resolution, as well as DKI parameters at 1.75\u2009mm isotropic. Overall, fractional anisotropy had the best reliability, with mean CoV at 5% for 1.25\u2009mm and 3.5% for 1.75\u2009mm isotropic voxels. Mean CoV for the other DTI metrics were &lt;7.0% for both 1.25 and 1.75\u2009mm isotropic voxels. The mean CoV was \u22644.5% across the DKI metrics. In the commonly injured orbitofrontal and temporal pole regions CoV was &lt;3.5% for all parameters. Thus, with appropriate processing, high spatial resolution advanced diffusion MRI has good to excellent test-retest reproducibility in both human cTBI patients and controls. However, further technical improvements will be needed to reliably discern the most subtle diffusion abnormalities, especially at high spatial resolution.<\/jats:p>","DOI":"10.1038\/s41598-017-11747-3","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T13:33:12Z","timestamp":1504618392000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Test-retest reliability of high spatial resolution diffusion tensor and diffusion kurtosis imaging"],"prefix":"10.1038","volume":"7","author":[{"given":"Pashtun","family":"Shahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurena","family":"Holleran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Brody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"11747_CR1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s12031-007-0029-0","volume":"34","author":"Y Assaf","year":"2008","unstructured":"Assaf, Y. & Pasternak, O. 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