{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:14:24Z","timestamp":1789478064896,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>By using the intravoxel incoherent motion (IVIM) model, the diffusion-related coefficient (D) and the perfusion-related parameter (<jats:italic>f<\/jats:italic>) can be obtained simultaneously. Here, we explored the application of IVIM MR imaging in predicting long-term prognosis in patients with advanced cervical cancers treated with concurrent chemo-radiotherapy (CCRT). In this study, pelvic MR examinations including an IVIM sequence were performed on 30 women with advanced cervical cancers at three time points (within 2 weeks before, as well as 2 and 4 weeks after, the initiation of CCRT). The performance of tumour size and IVIM-derived parameters in predicting long-term prognosis was evaluated. After a median follow-up of 24 months (range, 10\u223c34 months), 25\/30 (83.33%) patients were alive, and 21\/30 (70.00%) remained free of disease. A shrinkage rate of maximum diameter (time point 1 vs. 3)\u2009\u2265\u200958.31% was useful in predicting a good long-term prognosis. The IVIM-derived apparent diffusion coefficient (ADC<jats:sub>IVIM<\/jats:sub>) value at time point 2 and the ADC<jats:sub>IVIM<\/jats:sub> and <jats:italic>f<\/jats:italic> values at time point 3 also performed well in predicting a good prognosis, with AUC of 0.767, 0.857 and 0.820, respectively. IVIM MR imaging has great potential in predicting long-term prognosis in patients with advanced cervical cancers treated with CCRT.<\/jats:p>","DOI":"10.1038\/s41598-017-11988-2","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T10:34:47Z","timestamp":1505126087000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Predictive and prognostic value of intravoxel incoherent motion (IVIM) MR imaging in patients with advanced cervical cancers undergoing concurrent chemo-radiotherapy"],"prefix":"10.1038","volume":"7","author":[{"given":"Li","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baorui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"11988_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0167-8140(03)00197-X","volume":"68","author":"JM Kirwan","year":"2003","unstructured":"Kirwan, J. M. et al. A Systematic Review of Acute and Late Toxicity of Concomitant Chemoradiation for Cervical Cancer. Radiother Oncol. \n                           68, 217\u2013226 (2003).","journal-title":"Radiother Oncol."},{"key":"11988_CR2","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1200\/JCO.2004.07.197","volume":"22","author":"PJ Eifel","year":"2004","unstructured":"Eifel, P. J. et al. Pelvic Irradiation with Concurrent Chemotherapy Versus Pelvic and Para-Aortic Irradiation for High-Risk Cervical Cancer: An Update of Radiation Therapy Oncology Group Trial (Rtog) 90-01. J Clin Oncol. \n                           22, 872\u2013880 (2004).","journal-title":"J Clin Oncol."},{"key":"11988_CR3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/jmri.22167","volume":"32","author":"HC Thoeny","year":"2010","unstructured":"Thoeny, H. C. & Ross, B. D. Predicting and Monitoring Cancer Treatment Response with Diffusion-Weighted Mri. J Magn Reson Imaging. \n                           32, 2\u201316 (2010).","journal-title":"J Magn Reson Imaging."},{"key":"11988_CR4","first-page":"2495","volume":"36","author":"H Watanabe","year":"2009","unstructured":"Watanabe, H. et al. [New Response Evaluation Criteria in Solid Tumours-Revised Recist Guideline (Version 1.1)]. Gan to kagaku ryoho. Cancer & chemotherapy. \n                           36, 2495\u20132501 (2009).","journal-title":"Gan to kagaku ryoho. Cancer & chemotherapy."},{"key":"11988_CR5","first-page":"507","volume":"46","author":"MS Piver","year":"1975","unstructured":"Piver, M. S. & Chung, W. S. Prognostic Significance of Cervical Lesion Size and Pelvic Node Metastases in Cervical Carcinoma. Obstet Gynecol. \n                           46, 507\u2013510 (1975).","journal-title":"Obstet Gynecol."},{"key":"11988_CR6","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0360-3016(94)90220-8","volume":"29","author":"PJ Eifel","year":"1994","unstructured":"Eifel, P. J. et al. The Influence of Tumor Size and Morphology On the Outcome of Patients with Figo Stage Ib Squamous-Cell Carcinoma of the Uterine Cervix. Int J Radiat Oncol. \n                           29, 9\u201316 (1994).","journal-title":"Int J Radiat Oncol."},{"key":"11988_CR7","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1006\/gyno.1999.5420","volume":"74","author":"GB Kristensen","year":"1999","unstructured":"Kristensen, G. B. et al. Tumor Size, Depth of Invasion, and Grading of the Invasive Tumor Front are the Main Prognostic Factors in Early Squamous Cell Cervical Carcinoma. Gynecol Oncol. \n                           74, 245\u2013251 (1999).","journal-title":"Gynecol Oncol."},{"key":"11988_CR8","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.ygyno.2007.06.026","volume":"107","author":"LC Horn","year":"2007","unstructured":"Horn, L. C. et al. Tumor Size is of Prognostic Value in Surgically Treated Figo Stage Ii Cervical Cancer. Gynecol Oncol. \n                           107, 310\u2013315 (2007).","journal-title":"Gynecol Oncol."},{"key":"11988_CR9","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1097\/OGX.0b013e3181abc114","volume":"64","author":"VN Harry","year":"2009","unstructured":"Harry, V. N. et al. Predicting the Response of Advanced Cervical and Ovarian Tumors to Therapy. Obstet Gynecol Surv. \n                           64, 548\u2013560 (2009).","journal-title":"Obstet Gynecol Surv."},{"key":"11988_CR10","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1148\/radiology.189.2.8210364","volume":"189","author":"H Hricak","year":"1993","unstructured":"Hricak, H. et al. Irradiation of the Cervix Uteri - Value of Unenhanced and Contrast-Enhanced Mr-Imaging. Radiology. \n                           189, 381\u2013388 (1993).","journal-title":"Radiology."},{"key":"11988_CR11","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1148\/radiology.216.3.r00se07803","volume":"216","author":"Y Yamashita","year":"2000","unstructured":"Yamashita, Y. et al. Dynamic Contrast-Enhanced Mr Imaging of Uterine Cervical Cancer: Pharmacokinetic Analysis with Histopathologic Correlation and its Importance in Predicting the Outcome of Radiation Therapy. Radiology. \n                           216, 803\u2013809 (2000).","journal-title":"Radiology."},{"key":"11988_CR12","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ygyno.2008.07.048","volume":"111","author":"VN Harry","year":"2008","unstructured":"Harry, V. N. et al. Diffusion-Weighted Magnetic Resonance Imaging in the Early Detection of Response to Chemoradiation in Cervical Cancer. Gynecol Oncol. \n                           111, 213\u2013220 (2008).","journal-title":"Gynecol Oncol."},{"key":"11988_CR13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/RCT.0b013e3181f6528b","volume":"35","author":"Y Zhang","year":"2011","unstructured":"Zhang, Y. et al. Diffusion-Weighted Magnetic Resonance Imaging for Prediction of Response of Advanced Cervical Cancer to Chemoradiation. J Comput Assist Tomogr. \n                           35, 102\u2013107 (2011).","journal-title":"J Comput Assist Tomogr."},{"key":"11988_CR14","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1007\/s00330-012-2496-0","volume":"22","author":"G Somoye","year":"2012","unstructured":"Somoye, G. et al. Early Diffusion Weighted Magnetic Resonance Imaging Can Predict Survival in Women with Locally Advanced Cancer of the Cervix Treated with Combined Chemo-Radiation. Eur Radiol. \n                           22, 2319\u20132327 (2012).","journal-title":"Eur Radiol."},{"key":"11988_CR15","doi-asserted-by":"publisher","first-page":"R57","DOI":"10.1088\/0031-9155\/52\/7\/R02","volume":"52","author":"D Le Bihan","year":"2007","unstructured":"Le Bihan, D. The \u201cwet mind\u201d: water and functional neuroimaging. Phys Med Biol. \n                           52, R57\u2013R90 (2007).","journal-title":"Phys Med Biol."},{"key":"11988_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2116-5","volume":"16","author":"L Zhu","year":"2015","unstructured":"Zhu, L. et al. Evaluating Early Response of Cervical Cancer Under Concurrent Chemo-Radiotherapy by Intravoxel Incoherent Motion Mr Imaging. Bmc Cancer. \n                           16, 79 (2015).","journal-title":"Bmc Cancer."},{"key":"11988_CR17","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1002\/cncr.23817","volume":"113","author":"E Vincens","year":"2008","unstructured":"Vincens, E. et al. Accuracy of Magnetic Resonance Imaging in Predicting Residual Disease in Patients Treated for Stage Ib2\/Ii Cervical Carcinoma with Chemoradiation Therapy. Cancer. \n                           113, 2158\u20132165 (2008).","journal-title":"Cancer."},{"key":"11988_CR18","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/IGC.0b013e318197f185","volume":"19","author":"PJ Eifel","year":"2009","unstructured":"Eifel, P. J. et al. Predictive Value of a Proposed Subclassification of Stages I and Ii Cervical Cancer Based On Clinical Tumor Diameter. Int J Gynecol Cancer. \n                           19, 2\u20137 (2009).","journal-title":"Int J Gynecol Cancer."},{"key":"11988_CR19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/S0360-3016(01)01808-9","volume":"52","author":"NA Mayr","year":"2002","unstructured":"Mayr, N. A. et al. Method and Timing of Tumor Volume Measurement for Outcome Prediction in Cervical Cancer Using Magnetic Resonance Imaging. Int J Radiat Oncol. \n                           52, 14\u201322 (2002).","journal-title":"Int J Radiat Oncol."},{"key":"11988_CR20","first-page":"1408","volume":"58","author":"JM Brown","year":"1998","unstructured":"Brown, J. M. & Giaccia, A. J. The Unique Physiology of Solid Tumors: Opportunities (and Problems) for Cancer Therapy. Cancer Res. \n                           58, 1408\u20131416 (1998).","journal-title":"Cancer Res."},{"key":"11988_CR21","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1093\/jnci\/93.4.266","volume":"93","author":"M Hockel","year":"2001","unstructured":"Hockel, M. & Vaupel, P. Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects. J Natl Cancer Inst. \n                           93, 266\u2013276 (2001).","journal-title":"J Natl Cancer Inst."},{"key":"11988_CR22","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.semradonc.2004.04.008","volume":"14","author":"P Vaupel","year":"2004","unstructured":"Vaupel, P. Tumor Microenvironmental Physiology and its Implications for Radiation Oncology. Semin Radiat Oncol. \n                           14, 198\u2013206 (2004).","journal-title":"Semin Radiat Oncol."},{"key":"11988_CR23","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/0360-3016(88)90002-8","volume":"14","author":"RA Gatenby","year":"1988","unstructured":"Gatenby, R. A. et al. Oxygen Distribution in Squamous-Cell Carcinoma Metastases and its Relationship to Outcome of Radiation-Therapy. Int J Radiat Oncol. \n                           14, 831\u2013838 (1988).","journal-title":"Int J Radiat Oncol."},{"key":"11988_CR24","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.ejrad.2014.02.013","volume":"83","author":"T Hauser","year":"2014","unstructured":"Hauser, T. et al. Prediction of Treatment Response in Head and Neck Carcinomas Using Ivim-Dwi: Evaluation of Lymph Node Metastasis. Eur J Radiol. \n                           83, 783\u2013787 (2014).","journal-title":"Eur J Radiol."},{"key":"11988_CR25","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.radonc.2013.10.018","volume":"110","author":"C Ellingsen","year":"2014","unstructured":"Ellingsen, C. et al. Dce-Mri of the Hypoxic Fraction, Radioresponsiveness, and Metastatic Propensity of Cervical Carcinoma Xenografts. Radiother Oncol. \n                           110, 335\u2013341 (2014).","journal-title":"Radiother Oncol."},{"key":"11988_CR26","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/RLI.0b013e3181a64ce9","volume":"44","author":"WTC Yuh","year":"2009","unstructured":"Yuh, W. T. C. et al. Predicting Control of Primary Tumor and Survival by Dce Mri During Early Therapy in Cervical Cancer. Invest Radiol. \n                           44, 343\u2013350 (2009).","journal-title":"Invest Radiol."},{"key":"11988_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.brachy.2011.07.003","volume":"11","author":"AN Viswanathan","year":"2012","unstructured":"Viswanathan, A. N. & Thomadsen, B. American Brachytherapy Society Consensus Guidelines for Locally Advanced Carcinoma of the Cervix. Part I: General Principles. BRACHYTHERAPY. \n                           11, 33\u201346 (2012).","journal-title":"BRACHYTHERAPY."},{"key":"11988_CR28","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1002\/mrm.22565","volume":"64","author":"A Lemke","year":"2010","unstructured":"Lemke, A. et al. An in Vivo Verification of the Intravoxel Incoherent Motion Effect in Diffusion-Weighted Imaging of the Abdomen. Magn Reson Med. \n                           64, 1580\u20131585 (2010).","journal-title":"Magn Reson Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11988-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11988-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11988-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T10:57:29Z","timestamp":1671793049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-11988-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,14]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["11988"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-11988-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,14]]},"assertion":[{"value":"17 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"11635"}}