{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T13:44:44Z","timestamp":1794491084528,"version":"4.9.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antithyroid drug (ATD)-induced agranulocytosis is associated with human leukocyte antigen (HLA) and nearby genes in Southeast Asian and European populations. The susceptibility of the Han population from northern China to ATD-induced agranulocytosis has not been reported. We evaluated the associations of genetic variants at the<jats:italic>HLA-B<\/jats:italic>and<jats:italic>HLA-DRB1<\/jats:italic>loci and 32 candidate single nucleotide polymorphisms (SNPs) with agranulocytosis in 29 patients with ATD-induced agranulocytosis and in 140 patients with Graves\u2019 disease (GD) as controls. All subjects were of Han descent from northern China.<jats:italic>HLA-B*27:05<\/jats:italic>(P\u2009=\u20091.10\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>),<jats:italic>HLA-B*38:02<\/jats:italic>(P\u2009=\u20092.41\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>) and<jats:italic>HLA-DRB1*08:03<\/jats:italic>(P\u2009=\u20091.57\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>) were susceptibility HLA variants for ATD-induced agranulocytosis. All subjects carrying the<jats:italic>HLA-B*27:05<\/jats:italic>allele had agranulocytosis. The odds ratios (ORs) comparing allele carriers to non-carriers were 66.24 (95% confidence interval (CI): 3.54\u20131239.66) for<jats:italic>HLA-B*27:05<\/jats:italic>, 7.525 (95% CI: 2.294\u201324.68) for<jats:italic>HLA-B*38:02<\/jats:italic>and 4.316 (95% CI: 1.56\u201311.93) for<jats:italic>HLA-DRB1*08:03<\/jats:italic>. Two SNPs, rs2596487 (OR\u2009=\u20094.196, 95% CI\u2009=\u20092.086\u20138.441, P\u2009=\u20092.08\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>) and rs2228391 (OR\u2009=\u20093.621, 95% CI\u2009=\u20091.596\u20138.217, P\u2009=\u20091.2\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>), were independently associated with ATD-induced agranulocytosis. Subjects carrying the \u2018A\u2019 allele of rs1811197 or<jats:italic>HLA-B*38:02<\/jats:italic>showed lower minimum granulocyte counts than non-carriers (P\u2009=\u20094.74\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>and P\u2009=\u20097.39\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>, respectively). Our findings support the association between genetic variations of<jats:italic>HLA-B<\/jats:italic>and<jats:italic>HLA-DRB1<\/jats:italic>with ATD-induced agranulocytosis in a Han population from northern China.<\/jats:p>","DOI":"10.1038\/s41598-017-12350-2","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T10:09:11Z","timestamp":1505383751000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Association of HLA-B and HLA-DRB1 polymorphisms with antithyroid drug-induced agranulocytosis in a Han population from northern China"],"prefix":"10.1038","volume":"7","author":[{"given":"Yayi","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,20]]},"reference":[{"issue":"17","key":"12350_CR1","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1056\/NEJM200010263431707","volume":"343","author":"AP Weetman","year":"2000","unstructured":"Weetman, A. 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