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The most important phosphatase that is capable of dephosphorylating Tau at AD specific phospho-sites is protein phosphatase 2\u2009A (PP2A). Here we show that resveratrol, a polyphenol, significantly induces PP2A activity and reduces Tau phosphorylation at PP2A-dependent epitopes. The increase in PP2A activity is caused by decreased expression of the MID1 ubiquitin ligase that mediates ubiquitin-specific modification and degradation of the catalytic subunit of PP2A when bound to microtubules. Interestingly, we further show that MID1 expression is elevated in AD tissue. Our data suggest a key role of MID1 in the pathology of AD and related tauopathies. Together with previous studies showing that resveratrol reduces \u03b2-amyloid toxicity they also give evidence of a promising role for resveratrol in the prophylaxis and therapy of AD.<\/jats:p>","DOI":"10.1038\/s41598-017-12974-4","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T09:52:17Z","timestamp":1508233937000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex"],"prefix":"10.1038","volume":"7","author":[{"given":"Susann","family":"Schweiger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Matthes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Posey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Kickstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz M.","family":"Hettich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Pfurtscheller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Ehninger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sybille","family":"Krau\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"key":"12974_CR1","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1073\/pnas.94.1.298","volume":"94","author":"AD Alonso","year":"1997","unstructured":"Alonso, A. 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