{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:07:55Z","timestamp":1777486075833,"version":"3.51.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some studies have proved that both acupuncture and moxibustion are very effective for the treatment of CAG. However, little is known about therapeutic mechanism of electro-acupuncture and moxibustion on CAG as well as the difference between them. On the other hand, metabolomics is a \u2018top-down\u2019 approach to understand metabolic changes of organisms caused by disease or interventions in holistic context, which consists with the holistic thinking of electro-acupuncture and moxibustion treatment. In this study, the difference of therapeutic mechanism between electro-acupuncture and moxibustion on CAG rats was investigated by a<jats:sup>1<\/jats:sup>H NMR-based metabolomics analysis of multiple biological samples (serum, stomach, cerebral cortex and medulla) coupled with pathological examination and molecular biological assay. For all sample types, both electro-acupuncture and moxibustion intervention showed beneficial effects by restoring many CAG-induced metabolic changes involved in membrane metabolism, energy metabolism and function of neurotransmitters. Notably, the moxibustion played an important role in CAG treatment mainly by regulating energy metabolism in serum, while main acting site of electro-acupuncture treatment\u00a0was nervous system in stomach and brain. These findings are helpful to facilitate the therapeutic mechanism elucidating of electro-acupuncture and moxibustion on CAG rats. Metabolomics is promising in mechanisms study for traditional Chinese medicine (TCM).<\/jats:p>","DOI":"10.1038\/s41598-017-13195-5","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T14:47:25Z","timestamp":1508856445000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Comparative metabolomics study on therapeutic mechanism of electro-acupuncture and moxibustion on rats with chronic atrophic gastritis (CAG)"],"prefix":"10.1038","volume":"7","author":[{"given":"Cai-chun","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao-long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-rong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-da","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-cheng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-yu","family":"Lian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-qiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong-bao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"13195_CR1","volume":"2016","author":"Y Zhang","year":"2016","unstructured":"Zhang, Y. et al. Exploratory Factor Analysis for Validating Traditional Chinese Syndrome Patterns of Chronic Atrophic Gastritis. Evidence-based Complementary and Alternative Medicine: eCAM 2016, 6872890 (2016).","journal-title":"Evidence-based Complementary and Alternative Medicine: eCAM"},{"key":"13195_CR2","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/ijc.25476","volume":"128","author":"MA Adamu","year":"2011","unstructured":"Adamu, M. A., Weck, M. N., Rothenbacher, D. & Brenner, H. Incidence and risk factors for the development of chronic atrophic gastritis: Five year follow-up of a population-based cohort study. International journal of cancer 128, 1652\u20131658 (2011).","journal-title":"International journal of cancer"},{"key":"13195_CR3","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/gutjnl-2015-310846","volume":"65","author":"M Rugge","year":"2016","unstructured":"Rugge, M. et al. Chronicles of a cancer foretold: 35 years of gastric cancer risk assessment. Gut 65, 721\u2013725 (2016).","journal-title":"Gut"},{"key":"13195_CR4","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1080\/00365520802078341","volume":"43","author":"C Lewerin","year":"2008","unstructured":"Lewerin, C., Jacobsson, S., Lindstedt, G. & NilssonEhle, H. et al. Serum biomarkers for atrophic gastritis and antibodies against Helicobacter pylori in the elderly: Implications for vitamin B12, folic acid and iron status and response to oral vitamin therapy. Scandinavian Journal of Gastroenterology 43, 1050\u20131056 (2008).","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"13195_CR5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.7326\/0003-4819-134-5-200103060-00010","volume":"134","author":"T Ohkusa","year":"2001","unstructured":"Ohkusa, T. et al. Improvement in atrophic gastritis and intestinal metaplasia in patients in whom helicobacter pylori was eradicated. Annals of Internal Medicine 134, 380\u2013386 (2001).","journal-title":"Annals of Internal Medicine"},{"key":"13195_CR6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jso.2930510107","volume":"51","author":"S Rakic","year":"1992","unstructured":"Rakic, S., Pesko, P., Milicevic, M. & Gerzic, Z. Atrophic chronic gastritis and esophagogastric anastomotic leak after resection and reconstruction for esophageal carcinoma. Journal of Surgical Oncology 51, 19\u201321 (1992).","journal-title":"Journal of Surgical Oncology"},{"key":"13195_CR7","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1053\/j.gastro.2016.05.059","volume":"151","author":"A Donzelli","year":"2016","unstructured":"Donzelli, A. Helicobacter pylori Eradication? Gastroenterology 151, 773\u2013774 (2016).","journal-title":"Gastroenterology"},{"key":"13195_CR8","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1039\/C5FO00695C","volume":"6","author":"J Tian","year":"2015","unstructured":"Tian, J. et al. Investigation on the antidepressant effect of sea buckthorn seed oil through the GC-MS-based metabolomics approach coupled with multivariate analysis. Food & function 6, 3585\u20133592 (2015).","journal-title":"Food & function"},{"key":"13195_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168123","volume":"11","author":"Y Ma","year":"2016","unstructured":"Ma, Y. et al. Publication Trends in Acupuncture Research: A 20-Year Bibliometric Analysis Based on PubMed. PLoS ONE 11, e0168123, https:\/\/doi.org\/10.1371\/journal.pone.0168123 (2016).","journal-title":"PLoS ONE"},{"key":"13195_CR10","volume":"6","author":"Q Shu","year":"2016","unstructured":"Shu, Q. et al. Acupuncture and Moxibustion have Different Effects on Fatigue by Regulating the Autonomic Nervous System: A Pilot Controlled Clinical Trial. Scientific reports 6, 37846 (2016).","journal-title":"Scientific reports"},{"key":"13195_CR11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/00207450500341472","volume":"116","author":"MT Cab\u00fdoglu","year":"2006","unstructured":"Cab\u00fdoglu, M. T., Ergene, N. & Tan, U. International Journal of Neuroscience 116, 115\u2013125 (2006).","journal-title":"International Journal of Neuroscience"},{"key":"13195_CR12","volume":"12","author":"M Yang","year":"2017","unstructured":"Yang, M. et al. Moxibustion for pain relief in patients with primary dysmenorrhea: A randomized controlled trial. PLoS ONE 12, e0170952 (2017).","journal-title":"PLoS ONE"},{"key":"13195_CR13","volume":"6","author":"C Bao","year":"2016","unstructured":"Bao, C. et al. Different brain responses to electro-acupuncture and moxibustion treatment in patients with Crohn\u2019s disease. Scientific reports 6, 36636 (2016).","journal-title":"Scientific reports"},{"key":"13195_CR14","first-page":"361","volume":"29","author":"W Gu","year":"2009","unstructured":"Gu, W. & Hu, Q. C. Clinical observation on acupuncture for treatment of chronic atrophic gastritis. Chinese acupuncture & moxibustion. 29, 361\u2013364 (2009).","journal-title":"Chinese acupuncture & moxibustion."},{"key":"13195_CR15","first-page":"87","volume":"27","author":"X Gao","year":"2007","unstructured":"Gao, X., Yuan, J., Li, H. & Ren, S. Clinical research on acupuncture and moxibustion treatment of chronic atrophic gastritis. Journal of traditional Chinese medicine 27, 87\u201391 (2007).","journal-title":"Journal of traditional Chinese medicine"},{"key":"13195_CR16","volume":"2016","author":"J Zhang","year":"2016","unstructured":"Zhang, J. et al. Acupuncture Decreases NF-\u03baB p65, miR-155, and miR-21 and Increases miR-146a Expression in Chronic Atrophic Gastritis Rats. Evidence-Based Complementary and Alternative Medicine 2016, 9 (2016).","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"13195_CR17","first-page":"1269","volume":"35","author":"Z Yang","year":"2015","unstructured":"Yang, Z. et al. Effects of moxibustion on cell proliferative factors in gastric mucosa in rats with precancerous lesions of chronic atrophic gastritis. Chinese acupuncture & moxibustion 35, 1269\u20131273 (2015).","journal-title":"Chinese acupuncture & moxibustion"},{"key":"13195_CR18","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/4551054a","volume":"455","author":"JK Nicholson","year":"2008","unstructured":"Nicholson, J. K. & Lindon, J. C. Systems biology: Metabonomics. Nature 455, 1054\u20131056 (2008).","journal-title":"Nature"},{"key":"13195_CR19","unstructured":"Lindon, J. C., Nicholson, J. K. & Holmes, E. The handbook of metabonomics and metabolomics (Elsevier, 2011)."},{"key":"13195_CR20","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.jpba.2011.01.042","volume":"55","author":"X Wang","year":"2011","unstructured":"Wang, X. et al. Potential role of metabolomics apporoaches in the area of traditional Chinese medicine: As pillars of the bridge between Chinese and Western medicine. Journal of Pharmaceutical and Biomedical Analysis 55, 859\u2013868 (2011).","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"13195_CR21","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1039\/C4MB00370E","volume":"10","author":"ZY Li","year":"2014","unstructured":"Li, Z. Y., He, P., Sun, H. F., Qin, X. M. & Du, G. H. 1H NMR based metabolomic study of the antifatigue effect of Astragali Radix. Molecular BioSystems 10, 3022\u20133030 (2014).","journal-title":"Molecular BioSystems"},{"key":"13195_CR22","volume":"4","author":"L Zhang","year":"2014","unstructured":"Zhang, L. et al. Metabonomic Analysis Reveals Efficient Ameliorating Effects of Acupoint Stimulations on the Menopause-caused Alterations in Mammalian Metabolism. Scientific reports 4, 3641 (2014).","journal-title":"Scientific reports"},{"key":"13195_CR23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jchromb.2015.12.006","volume":"1009\u20131010","author":"L Ju","year":"2016","unstructured":"Ju, L. et al. Metabonomic study of the effects of different acupuncture directions on therapeutic efficacy. Journal of Chromatography B 1009\u20131010, 87\u201395 (2016).","journal-title":"Journal of Chromatography B"},{"key":"13195_CR24","volume":"2015","author":"J Xu","year":"2015","unstructured":"Xu, J. et al. 1H NMR Metabolic Profiling of Biofluids from Rats with Gastric Mucosal Lesion and Electroacupuncture Treatment. Evidence-based Complementary and Alternative Medicine: eCAM 2015, 801691 (2015).","journal-title":"Evidence-based Complementary and Alternative Medicine: eCAM"},{"key":"13195_CR25","volume":"7","author":"J Xu","year":"2017","unstructured":"Xu, J. et al. NMR-based metabolomics Reveals Alterations of Electro-acupuncture Stimulations on Chronic Atrophic Gastritis Rats. Scientific reports 7, 45580 (2017).","journal-title":"Scientific reports"},{"key":"13195_CR26","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.3748\/wjg.v19.i26.4214","volume":"19","author":"W Huang","year":"2013","unstructured":"Huang, W. et al. Effect of amitriptyline on gastrointestinal function and brain-gut peptides: A double-blind trial. World Journal of Gastroenterology: WJG 19, 4214\u20134220 (2013).","journal-title":"World Journal of Gastroenterology: WJG"},{"key":"13195_CR27","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.peptides.2012.03.018","volume":"35","author":"N Erin","year":"2012","unstructured":"Erin, N., T\u00fcrker, S., Elpek, \u00d6. & Y\u0131ld\u0131r\u0131m, B. Differential changes in Substance P, VIP as well as neprilysin levels in patients with gastritis or ulcer. Peptides 35, 218\u2013224 (2012).","journal-title":"Peptides"},{"key":"13195_CR28","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s00535-015-1124-6","volume":"51","author":"YJ Choi","year":"2016","unstructured":"Choi, Y. J. et al. Increase in plasma acyl ghrelin levels is associated with abatement of dyspepsia following Helicobacter pylori eradication. Journal of gastroenterology 51, 548\u2013559 (2016).","journal-title":"Journal of gastroenterology"},{"issue":"Part A","key":"13195_CR29","first-page":"1","volume":"158","author":"J Tian","year":"2014","unstructured":"Tian, J. et al. Dynamic analysis of the endogenous metabolites in depressed patients treated with TCM formula Xiaoyaosan using urinary 1H NMR-based metabolomics. Journal of Ethnopharm- acology 158(Part A), 1\u201310 (2014).","journal-title":"Journal of Ethnopharm- acology"},{"key":"13195_CR30","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.molmet.2016.07.011","volume":"5","author":"M El Azzouny","year":"2016","unstructured":"El Azzouny, M. et al. Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion. Molecular Metabolism 5, 980\u2013987 (2016).","journal-title":"Molecular Metabolism"},{"key":"13195_CR31","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.clinbiochem.2010.03.009","volume":"43","author":"M Lever","year":"2010","unstructured":"Lever, M. & Slow, S. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clinical biochemistry 43, 732\u2013744 (2010).","journal-title":"Clinical biochemistry"},{"key":"13195_CR32","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s13105-011-0107-1","volume":"67","author":"M Alirezaei","year":"2011","unstructured":"Alirezaei, M., Jelodar, G., Niknam, P., Ghayemi, Z. & Nazifi, S. Betaine prevents ethanol-induced oxidative stress and reduces total homocysteine in the rat cerebellum. Journal of physiology and biochemistry 67, 605\u2013612, https:\/\/doi.org\/10.1007\/s13105-011-0107-1 (2011).","journal-title":"Journal of physiology and biochemistry"},{"key":"13195_CR33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00726-016-2369-y","volume":"49","author":"R Castellano","year":"2017","unstructured":"Castellano, R. et al. Methionine and cysteine deficiencies altered proliferation rate and time-course differentiation of porcine preadipose cells. Amino acids 49, 355\u2013366 (2017).","journal-title":"Amino acids"},{"key":"13195_CR34","unstructured":"akagi, H. & Ohtsu, I. In Amino Acid Fermentation (eds Atsushi Yokota & Masato Ikeda) 129\u2013151 (Springer Japan, 2017)."},{"key":"13195_CR35","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1007\/s12010-016-2178-5","volume":"180","author":"Y Jiang","year":"2016","unstructured":"Jiang, Y. et al. Enzymatic Production of Glutathione by Bifunctional \u03b3-Glutamylcysteine Synthetase\/Glutathione Synthetase Coupled with In Vitro Acetate Kinase-Based ATP Generation. Applied biochemistry and biotechnology 180, 1446\u20131455 (2016).","journal-title":"Applied biochemistry and biotechnology"},{"key":"13195_CR36","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10535-014-0412-y","volume":"58","author":"D Del Buono","year":"2014","unstructured":"Del Buono, D., Mimmo, T., Terzano, R., Tomasi, N. & Cesco, S. Effect of cadmium on antioxidative enzymes, glutathione content, and glutathionylation in tall fescue. Biologia Plantarum 58, 773\u2013777 (2014).","journal-title":"Biologia Plantarum"},{"key":"13195_CR37","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/13813450701661198","volume":"113","author":"R Franco","year":"2007","unstructured":"Franco, R. et al. The central role of glutathione in the pathophysiology of human diseases. Archives of Physiology and Biochemistry 113, 234\u2013258 (2007).","journal-title":"Archives of Physiology and Biochemistry"},{"key":"13195_CR38","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2174\/1570159X14666160223120742","volume":"14","author":"D Sgambato","year":"2016","unstructured":"Sgambato, D. et al. Gut-Brain Axis in Gastric Mucosal Damage and Protection. Current neuropharmacology 14, 959\u2013966 (2016).","journal-title":"Current neuropharmacology"},{"key":"13195_CR39","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.bpg.2014.10.001","volume":"28","author":"G Holtmann","year":"2014","unstructured":"Holtmann, G. & Talley, N. J. The stomach\u2013brain axis. Best Practice & Research Clinical Gastroenterology 28, 967\u2013979 (2014).","journal-title":"Best Practice & Research Clinical Gastroenterology"},{"key":"13195_CR40","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s13361-017-1631-1","volume":"28","author":"CSR Ambati","year":"2017","unstructured":"Ambati, C. S. R., Yuan, F., Abu-Elheiga, L. A., Zhang, Y. & Shetty, V. Identification and Quantitation of Malonic Acid Biomarkers of In-Born Error Metabolism by Targeted Metabolomics. J. Am. Soc. Mass Spectrom. 28, 929\u2013938 (2017).","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"13195_CR41","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/1462-2920.13617","volume":"19","author":"M Klein","year":"2017","unstructured":"Klein, M., Swinnen, S., Thevelein, J. M. & Nevoigt, E. Glycerol metabolism and transport in yeast and fungi: established knowledge and ambiguities. Environmental microbiology 19, 878\u2013893 (2017).","journal-title":"Environmental microbiology"},{"key":"13195_CR42","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.mehy.2010.07.034","volume":"75","author":"SEJ Seybolt","year":"2010","unstructured":"Seybolt, S. E. J. Is it time to reassess alpha lipoic acid and niacinamide therapy in schizophrenia? Medical hypotheses 75, 572\u2013575 (2010).","journal-title":"Medical hypotheses"},{"key":"13195_CR43","doi-asserted-by":"crossref","first-page":"1539S","DOI":"10.1093\/jn\/137.6.1539S","volume":"137","author":"JD Fernstrom","year":"2007","unstructured":"Fernstrom, J. D. & Fernstrom, M. H. Tyrosine, Phenylalanine, and Catecholamine Synthesis and Function in the Brain. The Journal of nutrition 137, 1539S\u20131547S (2007).","journal-title":"The Journal of nutrition"},{"key":"13195_CR44","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1021\/acs.jproteome.6b00830","volume":"16","author":"A Oliveros","year":"2017","unstructured":"Oliveros, A. et al. Label-Free Neuroproteomics of the Hippocampal-Accumbal Circuit Reveals Deficits in Neurotransmitter and Neuropeptide Signaling in Mice Lacking Ethanol-Sensitive Adenosine Transporter. Journal of Proteome Research 16, 1445\u20131459 (2017).","journal-title":"Journal of Proteome Research"},{"key":"13195_CR45","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1242\/jcs.200055","volume":"130","author":"M Behm","year":"2017","unstructured":"Behm, M., Wahlstedt, H., Widmark, A., Eriksson, M. & \u00d6hman, M. Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development. Journal of Cell Science 130, 745\u2013753 (2017).","journal-title":"Journal of Cell Science"},{"key":"13195_CR46","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0091-2182(99)00054-3","volume":"44","author":"MW Beal","year":"1999","unstructured":"Beal, M. W. Acupuncture and Acupressure. Journal of Nurse-Midwifery 44, 217\u2013230 (1999).","journal-title":"Journal of Nurse-Midwifery"},{"key":"13195_CR47","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1525-1403.2010.00295.x","volume":"14","author":"T Takahashi","year":"2011","unstructured":"Takahashi, T. Mechanism of Acupuncture on Neuromodulation in the Gut\u2014A Review. Neuromodulation:Technology at the Neural Interface 14, 8\u201312 (2011).","journal-title":"Neuromodulation:Technology at the Neural Interface"},{"key":"13195_CR48","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jad.2015.05.005","volume":"185","author":"C-C Liu","year":"2015","unstructured":"Liu, C.-C. et al. Plasma-metabolite-biomarkers for the therapeutic response in depressed patients by the traditional Chinese medicine formula Xiaoyaosan: A 1H NMR-based metabolomics approach. Journal of Affective Disorders 185, 156\u2013163 (2015).","journal-title":"Journal of Affective Disorders"}],"updated-by":[{"DOI":"10.1038\/s41598-022-07361-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-13195-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-13195-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-13195-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:17:40Z","timestamp":1719533860000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-13195-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,30]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["13195"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-13195-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,30]]},"assertion":[{"value":"12 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 September 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-022-07361-7","URL":"https:\/\/doi.org\/10.1038\/s41598-022-07361-7","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"14362"}}