{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:58:13Z","timestamp":1759939093522},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Single-nucleotide polymorphisms (SNPs) in the <jats:italic>ETS1<\/jats:italic> gene are associated with several auto-inflammatory diseases. In this study, we determined whether <jats:italic>ETS1<\/jats:italic> gene polymorphisms confer susceptibility to idiopathic inflammatory myopathies (IIMs) in a northern Chinese Han population. DNA samples were collected from 1017 IIM patients: 363 PM cases and 654 DM cases. The results were compared with those of 1280 healthy controls. Five SNPs in the <jats:italic>ETS1<\/jats:italic> region (rs7117932, rs6590330, rs4937362, rs10893845 and rs1128334) were assessed and genotyped using the Sequenom platform. Our data indicated that the rs7117932 alleles and genotypes are associated with DM and IIMs (<jats:italic>P<\/jats:italic><jats:sub>\n                  <jats:italic>c<\/jats:italic>\n                <\/jats:sub>\u2009=\u20096.0\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup> and <jats:italic>P<\/jats:italic><jats:sub>\n                  <jats:italic>c<\/jats:italic>\n                <\/jats:sub>\u2009=\u20090.029; <jats:italic>P<\/jats:italic><jats:sub>\n                  <jats:italic>c<\/jats:italic>\n                <\/jats:sub>\u2009=\u20090.013 and <jats:italic>P<\/jats:italic><jats:sub>\n                  <jats:italic>c<\/jats:italic>\n                <\/jats:sub>\u2009=\u20090.019, respectively). We found a significantly greater percentage of DM and IIM patients with an A allele of rs6590330 than that in the control population (<jats:italic>P<\/jats:italic><jats:sub>\n                  <jats:italic>c<\/jats:italic>\n                <\/jats:sub>\u2009=\u20090.033 and <jats:italic>P<\/jats:italic><jats:sub>\n                  <jats:italic>c<\/jats:italic>\n                <\/jats:sub>\u2009=\u20090.013). Additionally, the rs6590330 genotype was associated with IIMs (<jats:italic>P<\/jats:italic><jats:sub>\n                  <jats:italic>c<\/jats:italic>\n                <\/jats:sub>\u2009=\u20090.020). The percentages of rs7117932 and rs6590330 SNPs were significantly greater in DM and IIM patients with interstitial lung disease (ILD) (all <jats:italic>P<\/jats:italic><jats:sub>\n                  <jats:italic>c<\/jats:italic>\n                <\/jats:sub>\u2009&lt;\u20090.05). This is the first study to reveal that <jats:italic>ETS1<\/jats:italic> polymorphisms are associated with IIMs alone and IIMs with ILD in a northern Chinese Han population.<\/jats:p>","DOI":"10.1038\/s41598-017-13385-1","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T10:22:40Z","timestamp":1507544560000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Single nucleotide polymorphisms in the ETS1 gene are associated with idiopathic inflammatory myopathies in a northern Chinese Han population"],"prefix":"10.1038","volume":"7","author":[{"given":"Si","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoting","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liubing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengchun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,13]]},"reference":[{"key":"13385_CR1","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1097\/00005792-199111000-00002","volume":"70","author":"LA Love","year":"1991","unstructured":"Love, L. A. et al. A New Approach to the Classification of Idiopathic Inflammatory Myopathy: Myositis-Specific Autoantibodies Define Useful Homogeneous Patient Groups. Medicine (Baltimore). \n                           70, 360\u2013374 (1991).","journal-title":"Medicine (Baltimore)."},{"key":"13385_CR2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1001\/jama.2010.1977","volume":"305","author":"LG Rider","year":"2011","unstructured":"Rider, L. G. & Miller, F. W. Deciphering the Clinical Presentations, Pathogenesis, and Treatment of the Idiopathic Inflammatory Myopathies. Jama. \n                           305, 183\u2013190 (2011).","journal-title":"Jama."},{"key":"13385_CR3","doi-asserted-by":"publisher","DOI":"10.1186\/ar3327","volume":"13","author":"H Chinoy","year":"2011","unstructured":"Chinoy, H., Lamb, J. A., Ollier, W. E. & Cooper, R. G. Recent Advances in the Immunogenetics of Idiopathic Inflammatory Myopathy. 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