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In a proof-of-concept study, we defined two groups (1) an acute STEMI group (n\u2009=\u20096, 83% male, age 54\u2009\u00b1\u200912 years) complicated by left ventricular (LV) systolic dysfunction; (2) an age- and sex- matched hyper-control group (n\u2009=\u20096, 83% male, age 46\u2009\u00b1\u200914 years), no prior history of cardiovascular disease and normal systolic blood pressure (SBP\u2009&lt;\u2009130\u2009mmHg). Cardiac MRI was performed in the patients (2 days &amp; 6 months post-STEMI) and the volunteers, and biomechanical heart models were synthesized for each subject. The candidate parameters included normalized active tension (\n                    <jats:italic>AT<\/jats:italic>\n                    <jats:sup>norm<\/jats:sup>\n                    ) and active tension at the resting sarcomere length (\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sup>req<\/jats:sup>\n                    , reflecting required contractility). Myocardial contractility was inversely determined from personalized heart models by matching CMR-imaged LV dynamics. Compared with controls, patients with recent STEMI exhibited increased LV wall active tension when normalized by SBP. We observed a linear relationship between\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sup>req<\/jats:sup>\n                    2 days post-MI and global longitudinal strain 6 months later (r\u2009=\u20090.86; p\u2009=\u20090.03).\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sup>req<\/jats:sup>\n                    may be associated with changes in LV function in the longer term in STEMI patients complicated by LV dysfunction. Further studies seem warranted.\n                  <\/jats:p>","DOI":"10.1038\/s41598-017-13635-2","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T05:19:43Z","timestamp":1507871983000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Estimating prognosis in patients with acute myocardial infarction using personalized computational heart models"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6852-9435","authenticated-orcid":false,"given":"Hao","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3505-7440","authenticated-orcid":false,"given":"Kenneth","family":"Mangion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Carrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-7413","authenticated-orcid":false,"given":"Dirk","family":"Husmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8753-4210","authenticated-orcid":false,"given":"Xiaoyu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-8636","authenticated-orcid":false,"given":"Colin","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"key":"13635_CR1","doi-asserted-by":"publisher","first-page":"e78","DOI":"10.1016\/j.jacc.2012.11.019","volume":"61","author":"PT O\u2019Gara","year":"2013","unstructured":"O\u2019Gara, P. 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