{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:07:52Z","timestamp":1793880472171,"version":"4.7.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:00:00Z","timestamp":1508371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:00:00Z","timestamp":1508371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During nervous system development growing axons can interact with each other, for example by adhering together in order to produce bundles (fasciculation). How does such axon-axon interaction affect the resulting axonal trajectories, and what are the possible benefits of this process in terms of network function? In this paper we study these questions by adapting an existing computational model of the development of neurons in the <jats:italic>Xenopus<\/jats:italic> tadpole spinal cord to include interactions between axons. We demonstrate that even relatively weak attraction causes bundles to appear, while if axons weakly repulse each other their trajectories diverge such that they fill the available space. We show how fasciculation can help to ensure axons grow in the correct location for proper network formation when normal growth barriers contain gaps, and use a functional spiking model to show that fasciculation allows the network to generate reliable swimming behaviour even when overall synapse counts are artificially lowered. Although we study fasciculation in one particular organism, our approach to modelling axon growth is general and can be widely applied to study other nervous systems.<\/jats:p>","DOI":"10.1038\/s41598-017-13804-3","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T10:17:08Z","timestamp":1507889828000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Studying the role of axon fasciculation during development in a computational model of the Xenopus tadpole spinal cord"],"prefix":"10.1038","volume":"7","author":[{"given":"Oliver","family":"Davis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8215-7527","authenticated-orcid":false,"given":"Robert","family":"Merrison-Hort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Soffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Borisyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"issue":"1","key":"13804_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8104-2-17","volume":"2","author":"WC Li","year":"2007","unstructured":"Li, W. C. et al. Axon and dendrite geography predict the specificity of synaptic connections in a functioning spinal cord network. Neural Development \n                           2(1), 17 (2007).","journal-title":"Neural Development"},{"key":"13804_CR2","doi-asserted-by":"crossref","unstructured":"Borisyuk, R., al Azad, A.K., Conte, D., Roberts, A. & Soffe, S.R. Modeling the connectome of a simple spinal cord. Frontiers in Neuroinformatics, 5 (2011)","DOI":"10.3389\/fninf.2011.00020"},{"key":"13804_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089461","volume":"9","author":"R Borisyuk","year":"2014","unstructured":"Borisyuk, R., al Azad, A. K., Conte, D., Roberts, A. & Soffe, S. R. A Developmental Approach to Predicting Neuronal Connectivity from Small Biological Datasets: A Gradient-Based Neuron Growth Model. 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Engl."},{"key":"13804_CR6","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1242\/dev.129.5.1251","volume":"129","author":"D Jhaveri","year":"2002","unstructured":"Jhaveri, D. & Rodrigues, V. Sensory neurons of the Atonal lineage pioneer the formation of glomeruli within the adult Drosophila olfactory lobe. Development \n                           129, 1251\u20131260 (2002).","journal-title":"Development"},{"key":"13804_CR7","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1006\/dbio.2000.9692","volume":"221","author":"N Fujita","year":"2002","unstructured":"Fujita, N., Saito, R., Watanabe, K. & Nagata, S. An Essential Role of the Neuronal Cell Adhesion Molecule Contactin in Development of the Xenopus Primary Sensory System. Dev. Biol. \n                           221, 308\u2013320, https:\/\/doi.org\/10.1006\/dbio.2000.9692 (2002).","journal-title":"Dev. Biol."},{"key":"13804_CR8","doi-asserted-by":"crossref","unstructured":"Lin, D. M., Fetter, R. D., Kopczynski, C., Grenningloh, G. & Goodman, C. S. Genetic analysis of Fasciclin II in Drosophila: defasciculation, refasciculation, and altered fasciculation. Neuron, 13(5), pp.1055\u20131069 (1994).","DOI":"10.1016\/0896-6273(94)90045-0"},{"key":"13804_CR9","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0529","volume":"369","author":"JS Kim","year":"2014","unstructured":"Kim, J. S. & Kaiser, M. From Caenorhabditis elegans to the human connectome: a specific modular organization increases metabolic, functional and developmental efficiency. Philosophical Transactions of the Royal Society B \n                           369, 1653 (2014).","journal-title":"Philosophical Transactions of the Royal Society B"},{"key":"13804_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8104-2-9","volume":"2","author":"N S\u00e1nchez-Soriano","year":"2007","unstructured":"S\u00e1nchez-Soriano, N., Tear, G., Whitington, P. & Prokop, A. 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