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Serotonin 5-HT\n                    <jats:sub>4<\/jats:sub>\n                    receptors are promising candidates in IBS pathophysiology since they regulate gut motor function and stool consistency, and targeted 5-HT\n                    <jats:sub>4<\/jats:sub>\n                    R selective drug intervention has been proven beneficial in subgroups of patients. We identified a single nucleotide polymorphism (SNP) (rs201253747) c.*61\u2009T\u2009&gt;\u2009C within the 5-HT\n                    <jats:sub>4<\/jats:sub>\n                    receptor gene\n                    <jats:italic>HTR4<\/jats:italic>\n                    to be predominantly present in diarrhoea-IBS patients (IBS-D). It affects a binding site for the miR-16 family and miR-103\/miR-107 within the isoforms\n                    <jats:italic>HTR4b\/i<\/jats:italic>\n                    and putatively impairs\n                    <jats:italic>HTR4<\/jats:italic>\n                    expression. Subsequent miRNA-profiling revealed downregulation of miR-16 and miR-103 in the jejunum of IBS-D patients correlating with symptoms.\n                    <jats:italic>In vitro<\/jats:italic>\n                    assays confirmed expression regulation via three 3\u2032UTR binding sites. The novel isoform\n                    <jats:italic>HTR4b_2<\/jats:italic>\n                    lacking two of the three miRNA binding sites escapes miR-16\/103\/107 regulation in SNP carriers. We provide the first evidence that\n                    <jats:italic>HTR4<\/jats:italic>\n                    expression is fine-tuned by miRNAs, and that this regulation is impaired either by the SNP c.*61\u2009T\u2009&gt;\u2009C or by diminished levels of miR-16 and miR-103 suggesting that\n                    <jats:italic>HTR4<\/jats:italic>\n                    might be involved in the development of IBS-D.\n                  <\/jats:p>","DOI":"10.1038\/s41598-017-13982-0","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T09:51:54Z","timestamp":1508925114000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome"],"prefix":"10.1038","volume":"7","author":[{"given":"Carolin","family":"Wohlfarth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Schmitteckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina D.","family":"H\u00e4rtle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley 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