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In this work, a liquid-infused nitric oxide-releasing (LINORel) material is created by incorporating the nitric oxide (NO) donor<jats:italic>S<\/jats:italic>-nitroso-acetylpenicillamine (SNAP) and silicone oil in commercial medical grade silicone rubber tubing through a solvent swelling process. This combination provides several key advantages over previous NO-releasing materials, including decreased leaching of NO donor, controlled release of NO, and maintenance of ultra-low fouling property of liquid-infused materials. The LINORel tubing reduces protein adhesion as observed using fluorescence imaging, and platelet adhesion (81.7\u2009\u00b1\u20092.5%)<jats:italic>in vitro<\/jats:italic>over a 2\u2009h period. The LINORel combination greatly reduces bacterial adhesion and biofilm formation of two most common pathogens responsible for hospital acquired infections: gram-positive<jats:italic>Staphylococcus aureus<\/jats:italic>and gram-negative<jats:italic>Pseudomonas aeruginosa<\/jats:italic>(99.3\u2009\u00b1\u20091.9% and 88.5\u2009\u00b1\u20093.3% respectively) over a 7-day period in a CDC bioreactor environment. Overall, the LINORel approach provides a synergistic combination of active and passive non-fouling approaches to increase biocompatibility and reduce infection associated with medical devices.<\/jats:p>","DOI":"10.1038\/s41598-017-14012-9","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T15:31:35Z","timestamp":1507908695000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":117,"title":["Liquid-infused nitric oxide-releasing (LINORel) silicone for decreased fouling, thrombosis, and infection of medical devices"],"prefix":"10.1038","volume":"7","author":[{"given":"Marcus J.","family":"Goudie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0514-0347","authenticated-orcid":false,"given":"Jitendra","family":"Pant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh","family":"Handa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"key":"14012_CR1","doi-asserted-by":"crossref","unstructured":"Brisbois, E. 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