{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:10:06Z","timestamp":1785928206936,"version":"3.56.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A randomized controlled longitudinal field trial was undertaken to assess the effects of injectable ceftiofur crystalline-free acid (CCFA) versus in-feed chlortetracycline on the temporal dynamics of <jats:italic>Salmonella enterica<\/jats:italic> spp. <jats:italic>enterica<\/jats:italic> in feedlot cattle. Two replicates of 8 pens (total 176 steers) received one of 4 different regimens. All, or one, out of 11 steers were treated with CCFA on day 0 in 8 pens, with half of the pens later receiving three 5-day regimens of chlortetracycline from day 4 to day 20. <jats:italic>Salmonella<\/jats:italic> was isolated from faecal samples and antimicrobial susceptibility was analysed via microbroth dilution. Serotype was determined by whole-genome sequencing. On day 0, mean <jats:italic>Salmonella<\/jats:italic> prevalence was 75.0% and the vast majority of isolates were pansusceptible. Both antimicrobials reduced overall prevalence of <jats:italic>Salmonella<\/jats:italic>; however, these treatments increased the proportion of multi-drug resistant (MDR) <jats:italic>Salmonella<\/jats:italic> from day 4 through day 26, which was the last day of faecal collection. Only six <jats:italic>Salmonella<\/jats:italic> serotypes were detected. <jats:italic>Salmonella<\/jats:italic> serotype Reading isolates were extensively MDR, suggesting a strong association between serotype and resistance. Our study demonstrates that the selection pressures of a 3<jats:sup>rd<\/jats:sup> generation cephalosporin and chlortetracycline during the feeding period contribute to dynamic population shifts between antimicrobial susceptible and resistant <jats:italic>Salmonella<\/jats:italic>.<\/jats:p>","DOI":"10.1038\/s41598-017-14751-9","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T09:29:25Z","timestamp":1508837365000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Population dynamics of enteric Salmonella in response to antimicrobial use in beef feedlot cattle"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5790-3137","authenticated-orcid":false,"given":"Naomi","family":"Ohta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keri N.","family":"Norman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Norby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9154-8909","authenticated-orcid":false,"given":"Sara D.","family":"Lawhon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Vinasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"den Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy H.","family":"Loneragan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-5961","authenticated-orcid":false,"given":"H. Morgan","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"14751_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3201\/eid1701.P11101","volume":"17","author":"E Scallan","year":"2011","unstructured":"Scallan, E. et al. Foodborne illness acquired in the United States\u2013major pathogens. Emerg Infect Dis \n                           17, 7\u201315, https:\/\/doi.org\/10.3201\/eid1701.091101p1 (2011).","journal-title":"Emerg Infect Dis"},{"key":"14751_CR2","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1111\/j.1651-2227.2003.tb02502.x","volume":"92","author":"TY Lin","year":"2003","unstructured":"Lin, T. Y. et al. Short-term ceftriaxone therapy for treatment of severe non-typhoidal Salmonella enterocolitis. 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