{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T17:51:09Z","timestamp":1794333069745,"version":"4.9.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Swallowing is a very important and complex physiological behaviour. The dynamic of swallowing has created great interest as any procedural abnormality will result in dysphagia and even lower quality of life. However, a non-invasive evaluation of biomechanical coordination during oropharyngeal swallowing, which includes the activities of the tongue, the hyoid and swallowing-related muscles, has not yet been achieved. In the present study, we recruited fifteen subjects, and a non-invasive sensing system composed of a pressure sensor, a bend sensor, surface electrodes and a microphone was created to simultaneously monitor tongue pressure, hyoid motion, and surface EMG of swallowing-related muscles, as well as take sound recordings, when the subjects swallowed 5\u2009ml of water. In addition to obtaining the durations of certain motor events, the considerable time (beginning, peak and ending time) of tongue pressure production, suprahyoid and infrahyoid muscle activity and hyoid motion were successfully measured. Moreover, the significant correlations between swallowing-related muscles, tongue pressure, and the hyoid were confirmed. These findings suggest that the non-invasive sensing system has potential as a good candidate for monitoring and evaluating the oropharyngeal process of swallowing, which may be useful in clinical work involving dysphagia evaluation and rehabilitation.<\/jats:p>","DOI":"10.1038\/s41598-017-15243-6","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T14:35:46Z","timestamp":1509719746000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The biomechanical coordination during oropharyngeal swallowing: an evaluation with a non-invasive sensing system"],"prefix":"10.1038","volume":"7","author":[{"given":"Qiang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitomo","family":"Minagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehiro","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"15243_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/BF02407219","volume":"3","author":"WJ Dodds","year":"1989","unstructured":"Dodds, W. J. Physiology of swallowing. Dysphagia. \n                           3, 171\u2013178 (1989).","journal-title":"Dysphagia."},{"key":"15243_CR2","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1007\/s11136-015-0990-y","volume":"24","author":"K Swan","year":"2015","unstructured":"Swan, K., Speyer, R., Heijnen, B. J., Wagg, B. & Cordier, R. Living with oropharyngeal dysphagia: effects of bolus modification on health-related quality of life\u2013a systematic review. Qual. Life. Res. \n                           24, 2447\u20132456 (2015).","journal-title":"Qual. Life. Res."},{"key":"15243_CR3","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1152\/japplphysiol.91295.2008","volume":"106","author":"T Tsukada","year":"2009","unstructured":"Tsukada, T., Taniguchi, H., Ootaki, S., Yamada, Y. & Inoue, M. Effects of food texture and head posture on oropharyngeal swallowing. J. Appl. Physiol. \n                           106, 1848\u20131857 (2009).","journal-title":"J. Appl. Physiol."},{"key":"15243_CR4","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1152\/japplphysiol.90485.2008","volume":"105","author":"H Taniguchi","year":"2008","unstructured":"Taniguchi, H., Tsukada, T., Ootaki, S., Yamada, Y. & Inoue, M. Correspondence between food consistency and suprahyoid muscle activity, tongue pressure, and bolus transit times during the oropharyngeal phase of swallowing. J. Appl. Physiol. \n                           105, 791\u2013799 (2008).","journal-title":"J. Appl. Physiol."},{"key":"15243_CR5","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/BF02407118","volume":"1","author":"M Stone","year":"1986","unstructured":"Stone, M. & Shawker, T. H. An ultrasound examination of tongue movement during swallowing. Dysphagia. \n                           1, 78\u201383 (1986).","journal-title":"Dysphagia."},{"key":"15243_CR6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00455-004-0010-9","volume":"19","author":"T Ono","year":"2004","unstructured":"Ono, T., Hori, K. & Nokubi, T. Pattern of tongue pressure on hard palate during swallowing. Dysphagia. \n                           19, 259\u2013264 (2004).","journal-title":"Dysphagia."},{"key":"15243_CR7","first-page":"G748","volume":"257","author":"IJ Cook","year":"1989","unstructured":"Cook, I. J. et al. Opening mechanisms of the human upper esophageal sphincter. Am. J. Physiol. \n                           257, G748\u2013G759 (1989).","journal-title":"Am. J. Physiol."},{"key":"15243_CR8","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/BF02493469","volume":"7","author":"JB Palmer","year":"1992","unstructured":"Palmer, J. B., Rudin, N. J., Lara, G. & Crompton, A. W. Coordination of mastication and swallowing. Dysphagia. \n                           7, 187\u2013200 (1992).","journal-title":"Dysphagia."},{"key":"15243_CR9","first-page":"37","volume":"23","author":"RO Dantas","year":"1990","unstructured":"Dantas, R. O. & Dodds, W. J. Effect of bolus volume and consistency on swallow-induced submental and infrahyoid electromyographic activity. Braz. J. Med. Biol. Res. \n                           23, 37\u201344 (1990).","journal-title":"Braz. J. Med. Biol. Res."},{"key":"15243_CR10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/BF02407397","volume":"4","author":"IJ Cook","year":"1989","unstructured":"Cook, I. J. et al. Timing of videofluoroscopic, manometric events, and bolus transit during the oral and pharyngeal phases of swallowing. Dysphagia. \n                           4, 8\u201315 (1989).","journal-title":"Dysphagia."},{"key":"15243_CR11","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1288\/00005537-199403000-00017","volume":"104","author":"T Gay","year":"1994","unstructured":"Gay, T., Rendell, J. K. & Spiro, J. Oral and laryngeal muscle coordination during swallowing. Laryngoscope. \n                           104, 341\u2013349 (1994).","journal-title":"Laryngoscope."},{"key":"15243_CR12","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1002\/mus.880181014","volume":"18","author":"C Ertekin","year":"1995","unstructured":"Ertekin, C. et al. An electrophysiological investigation of deglutition in man. Muscle. Nerve. \n                           18, 1177\u20131186 (1995).","journal-title":"Muscle. Nerve."},{"key":"15243_CR13","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1044\/1092-4388(2006\/015)","volume":"49","author":"MA Crary","year":"2006","unstructured":"Crary, M. A., Carnaby, Mann, G. D. & Groher, M. E. Biomechanical correlates of surface electromyography signals obtained during swallowing by healthy adults. J. Speech. Lang. Hear. Res. \n                           49, 186\u2013193 (2006).","journal-title":"J. Speech. Lang. Hear. Res."},{"key":"15243_CR14","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1007\/s00405-013-2406-3","volume":"270","author":"C Schultheiss","year":"2013","unstructured":"Schultheiss, C., Schauer, T., Nahrstaedt, H. & Seidl, R. O. Evaluation of an EMG bioimpedance measurement system for recording and analysing the pharyngeal phase of swallowing. Eur. Arch. Otorhinolaryngol. \n                           270, 2149\u20132156 (2013).","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"15243_CR15","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/00005537-199703000-00023","volume":"107","author":"CH Wu","year":"1997","unstructured":"Wu, C. H., Hsiao, T. Y., Chen, J. C., Chang, Y. C. & Lee, S. Y. Evaluation of swallowing safety with fiberoptic endoscope: comparison with videofluoroscopic technique. Laryngoscope. \n                           107, 396\u2013401 (1997).","journal-title":"Laryngoscope."},{"key":"15243_CR16","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s00455-010-9276-2","volume":"26","author":"Y Inamoto","year":"2011","unstructured":"Inamoto, Y. et al. Evaluation of swallowing using 320-detector-row multislice CT. Part II: kinematic analysis of laryngeal closure during normal swallowing. Dysphagia. \n                           26, 209\u2013217 (2011).","journal-title":"Dysphagia."},{"key":"15243_CR17","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/jmri.20992","volume":"26","author":"Y Honda","year":"2007","unstructured":"Honda, Y. & Hata, N. Dynamic imaging of swallowing in a seated position using open-configuration MRI. J. Magn. Reson. Imaging. \n                           26, 172\u2013176 (2007).","journal-title":"J. Magn. Reson. Imaging."},{"key":"15243_CR18","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s12194-010-0107-9","volume":"4","author":"K Yabunaka","year":"2011","unstructured":"Yabunaka, K. et al. Sonographic assessment of hyoid bone movement during swallowing: a study of normal adults with advancing age. Radiol. Phys. Technol. \n                           4, 73\u201377 (2011).","journal-title":"Radiol. Phys. Technol."},{"key":"15243_CR19","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1460-6984.2011.00082.x","volume":"47","author":"C Steele","year":"2012","unstructured":"Steele, C., Sasse, C. & Bressmann, T. Tongue-pressure and hyoid movement timing in healthy liquid swallowing. Int J Lang Commun Disord. \n                           47, 77\u201383 (2012).","journal-title":"Int J Lang Commun Disord."},{"key":"15243_CR20","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jpor.2008.08.008","volume":"53","author":"K Hori","year":"2009","unstructured":"Hori, K. et al. Newly developed sensor sheet for measuring tongue pressure during swallowing. J. Prosthodont. Res. \n                           53, 28\u201332 (2009).","journal-title":"J. Prosthodont. Res."},{"key":"15243_CR21","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.physbeh.2015.05.004","volume":"147","author":"Q Li","year":"2015","unstructured":"Li, Q. et al. Coordination in oro-pharyngeal biomechanics during human swallowing. Physiol. Behav. \n                           147, 300\u2013305 (2015).","journal-title":"Physiol. Behav."},{"key":"15243_CR22","doi-asserted-by":"publisher","first-page":"582","DOI":"10.2186\/jjps.45.582","volume":"45","author":"H Alzawa","year":"2001","unstructured":"Alzawa, H., Sasaki, K. & Watanabe, M. The time course of jaw and hyoid muscle activities during swallowing following mastication. J. Jpn. Prosthodont. Soc. \n                           45, 582\u2013591 (2001).","journal-title":"J. Jpn.Prosthodont.Soc."},{"key":"15243_CR23","doi-asserted-by":"publisher","first-page":"e70850","DOI":"10.1371\/journal.pone.0070850","volume":"8","author":"Q Li","year":"2013","unstructured":"Li, Q. et al. Development of a system to monitor laryngeal movement during swallowing using a bend sensor. PLoS. One. \n                           8, e70850 (2013).","journal-title":"PLoS. One."},{"key":"15243_CR24","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/BF00341261","volume":"9","author":"K Takahashi","year":"1994","unstructured":"Takahashi, K., Groher, M. E. & Michi, K. Symmetry and reproducibility of swallowing sounds. Dysphagia. \n                           9, 168\u2013173 (1994).","journal-title":"Dysphagia."},{"key":"15243_CR25","first-page":"54","volume":"9","author":"K Takahashi","year":"1994","unstructured":"Takahashi, K., Groher, M. E. & Michi, K. Methodology for detecting swallowing sounds. Dysphagia. \n                           9, 54\u201362 (1994).","journal-title":"Dysphagia."},{"key":"15243_CR26","first-page":"493","volume":"22","author":"T Ono","year":"2009","unstructured":"Ono, T. et al. Evaluation of tongue-, jaw-, and swallowing-related muscle coordination during voluntarily triggered swallowing. Int. J. Prosthodont. \n                           22, 493\u2013498 (2009).","journal-title":"Int. J. Prosthodont."},{"key":"15243_CR27","doi-asserted-by":"publisher","first-page":"e00167","DOI":"10.1002\/phy2.167","volume":"1","author":"K Hori","year":"2013","unstructured":"Hori, K. et al. Role of tongue pressure production in oropharyngeal swallow biomechanics. Physiol. Rep. \n                           1, e00167 (2013).","journal-title":"Physiol. Rep."},{"key":"15243_CR28","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1152\/japplphysiol.00467.2013","volume":"115","author":"T Okada","year":"2013","unstructured":"Okada, T. et al. Dynamic change in hyoid muscle length associated with trajectory of hyoid bone during swallowing: analysis using 320-row area detector computed tomography. J. Appl. Physiol. \n                           115, 1138\u20131145 (2013).","journal-title":"J. Appl. Physiol."},{"key":"15243_CR29","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/s00455-010-9292-2","volume":"26","author":"K Hori","year":"2011","unstructured":"Hori, K. et al. Influence of chin-down posture on tongue pressure during dry swallow and bolus swallows in healthy subjects. Dysphagia. \n                           26, 238\u2013245 (2011).","journal-title":"Dysphagia."},{"key":"15243_CR30","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1177\/0022034510370801","volume":"89","author":"K Tamine","year":"2010","unstructured":"Tamine, K. et al. Age-related changes in tongue pressure during swallowing. J. Dent. Res. \n                           89, 1097\u20131101 (2010).","journal-title":"J. Dent. Res."},{"key":"15243_CR31","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.2214\/ajr.153.6.1197","volume":"153","author":"WJ Dodds","year":"1989","unstructured":"Dodds, W. J. et al. Tipper anddipper types of oral swallows. AJR. Am. J. Roentgenol. \n                           153, 1197\u20131199 (1989).","journal-title":"AJR. Am. J. Roentgenol."},{"key":"15243_CR32","doi-asserted-by":"crossref","unstructured":"Lowe, A. A. Neural control of tongue posture. In Neurophysiology of Jawand Teeth (ed. Taylor, A.) 322-368 (Macmillan, 1990).","DOI":"10.1007\/978-1-349-08964-2_10"},{"key":"15243_CR33","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00455-012-9410-4","volume":"28","author":"Y Inamoto","year":"2013","unstructured":"Inamoto, Y. et al. The effect of bolus viscosity on laryngeal closure in swallowing: kinematic analysis using 320-row area detector CT. Dysphagia. \n                           28, 33\u201342 (2013).","journal-title":"Dysphagia."},{"key":"15243_CR34","first-page":"1","volume":"186","author":"DJ Vandaele","year":"1995","unstructured":"Vandaele, D. J., Perlman, A. L. & Cassell, M. D. Intrinsic fibre architecture and attachments of the human epiglottis and their contributions to the mechanism of deglutition. J. Anat. \n                           186, 1\u201315 (1995).","journal-title":"J. Anat."},{"key":"15243_CR35","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/0016-5085(88)90290-9","volume":"5","author":"PJ Kahrilas","year":"1988","unstructured":"Kahrilas, P. J., Dodds, W. J., Dent, J., Logemann, J. A. & Shaker, R. Upper esophageal sphincter function during deglutition. Gastroenterology. \n                           5, 52\u201362 (1988).","journal-title":"Gastroenterology."},{"key":"15243_CR36","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00455-010-9315-z","volume":"26","author":"WG Pearson Jr.","year":"2011","unstructured":"Pearson, W. G. Jr., Langmore, S. E. & Zumwalt, A. C. Evaluating the structural properties of suprahyoid muscles and their potential for moving the hyoid. Dysphagia. \n                           26, 345\u2013351 (2011).","journal-title":"Dysphagia."},{"key":"15243_CR37","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1590\/S0004-28032011000300008","volume":"48","author":"RO Dantas","year":"2011","unstructured":"Dantas, R. O., Alves, L. M., Santos, C. M. & CassianiRde, A. Possible interaction of gender and age on human swallowing behavior. Arq. Gastroenterol. \n                           48, 195\u2013198 (2011).","journal-title":"Arq. Gastroenterol."},{"key":"15243_CR38","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1044\/1092-4388(2002\/034)","volume":"45","author":"JA Logemann","year":"2002","unstructured":"Logemann, J. A., Pauloski, B. R., Rademaker, A. W. & Kahrilas, P. J. Oropharyngeal swallow in younger and older women: videofluoroscopic analysis. J. Speech. Lang. Hear. Res. \n                           45, 434\u2013445 (2002).","journal-title":"J. Speech. Lang. Hear. Res."},{"key":"15243_CR39","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/j.1365-2842.2008.01927.x","volume":"36","author":"D Inagaki","year":"2009","unstructured":"Inagaki, D., Miyaoka, Y., Ashida, I. & Yamada, Y. Influence of food properties and body position on swallowing-related muscle activity amplitude. J. Oral. Rehabil. \n                           36, 176\u2013183 (2009).","journal-title":"J. Oral. Rehabil."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-15243-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-15243-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-15243-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T13:28:45Z","timestamp":1671802125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-15243-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,9]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["15243"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-15243-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,9]]},"assertion":[{"value":"14 March 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"15165"}}