{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:24:46Z","timestamp":1760909086240,"version":"3.37.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increased N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentration predicts poor prognosis of non-CNS cancer patients. We evaluated the association of NT-proBNP concentration with disease severity, discharge outcomes and prognosis of patients undergoing craniotomy for brain tumor. From January, 2010 until September, 2011 two-hundred and forty-five patients (age 55.05\u2009\u00b1\u200914.62 years) admitted for brain tumor surgery were evaluated for NT-proBNP serum concentration. Outcome at hospital discharge was evaluated with the Glasgow Outcome Scale (GOS). Most common diagnoses were meningioma (37%) and high-grade glioma (20%). Greater NT-proBNP concentration was associated with lower Barthel index (rho\u2009=\u2009\u22120.305, p\u2009=\u20090.001) and Mini Mental State Examination scores (rho\u2009=\u2009\u22120.314, p\u2009=\u20090.001) and with greater Hospital Anxiety and Depression scale Depression score (rho\u2009=\u20090.240, p\u2009=\u20090.026). Greater admission NT-proBNP concentration was associated with lower discharge GOS score after adjusting for patient age, gender and histological brain tumor diagnosis (\u03b2\u2009=\u2009\u22120.253, p\u2009&lt;\u20090.001). Greater NT-proBNP concentration was also associated with greater 5-year mortality risk (HR\u2009=\u20091.845; 95%CI [1.166\u20132.920], p\u2009=\u20090.009) controlling for patient age, gender, history of cardiovascular disease, histological diagnosis and adjuvant therapy. In sum, greater pre-operative NT-proBNP concentration is associated with worse health status, unfavorable discharge outcome and shorter survival of brain tumor patients.<\/jats:p>","DOI":"10.1038\/s41598-017-15394-6","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T20:38:11Z","timestamp":1509568691000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Preoperative N-terminal pro-B-type natriuretic peptide concertation and prognosis of brain tumor patients: a 5-year follow up study"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0446-6898","authenticated-orcid":false,"given":"Adomas","family":"Bunevicius","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vytenis","family":"Deltuva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward R.","family":"Laws","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Iervasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arimantas","family":"Tamsauskas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robertas","family":"Bunevicius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"15394_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ejheart.2003.12.015","volume":"6","author":"C Hall","year":"2004","unstructured":"Hall, C. Essential biochemistry and physiology of (NT-pro)BNP. Eur J Heart Fail \n                           6, 257\u2013260 (2004).","journal-title":"Eur J Heart Fail"},{"key":"15394_CR2","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jchf.2013.11.007","volume":"2","author":"G Savarese","year":"2014","unstructured":"Savarese, G. et al. Changes of natriuretic peptides predict hospital admissions in patients with chronic heart failure: a meta-analysis. JACC Heart Fail \n                           2, 148\u2013158 (2014).","journal-title":"JACC Heart Fail"},{"key":"15394_CR3","first-page":"217","volume":"13","author":"H Imura","year":"1992","unstructured":"Imura, H., Nakao, K. & Itoh, H. The natriuretic peptide system in the brain: implications in the central control of cardiovascular and neuroendocrine functions. 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