{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:25:03Z","timestamp":1792513503623,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gallstone disease (GD) is a common digestive disorder that shares many risk factors with cardiovascular disease (CVD). CVD is an important public health issue that encompasses a large percentage of overall mortality. Several recent studies have suggested an association between GD and CVD, while others have not. In this report, we present a meta-analysis of cohort studies to assess the association between GD and CVD. We included eight studies published from 1980 to 2017, including nearly one million participants. The pooled relative risk (RR, 95% confidence interval [CI]) from the random-effects model associates with GD is 1.23 (95% CI: 1.17\u20131.30) for fatal and nonfatal CVD events. The pooled RR from the random-effects model of CVD events in female patients with GD is 1.24 (95% CI: 1.16\u20131.32). In male GD patients, the pooled RR from the random-effects model for CVD is 1.18 (95% CI: 1.06\u20131.31). Our meta-analysis demonstrates a substantially increased risk of fatal and nonfatal CVD events among patients with a medical history of GD. We suggest that interested investigators should further pursue the subject. In addition, both male and female patients with GD have a risk of CVD, and women have a higher risk than men.<\/jats:p>","DOI":"10.1038\/s41598-017-15430-5","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T20:26:19Z","timestamp":1509654379000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The relation between gallstone disease and cardiovascular disease"],"prefix":"10.1038","volume":"7","author":[{"given":"Lai lai","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi juan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"key":"15430_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jss.2011.06.064","volume":"175","author":"J Freeman","year":"2012","unstructured":"Freeman, J., Boomer, L., Fursevich, D. & Feliz, A. Ethnicity and insurance status affect health disparities in patients with gallstone disease. The Journal of surgical research \n                           175, 1\u20135, https:\/\/doi.org\/10.1016\/j.jss.2011.06.064 (2012).","journal-title":"The Journal of surgical research"},{"key":"15430_CR2","first-page":"1","volume":"14","author":"J Liu","year":"2014","unstructured":"Liu, J. et al. Non-alcoholic fatty liver disease associated with gallstones in females rather than males: a longitudinal cohort study in Chinese urban population. BMC Gastroenterol. \n                           14, 1\u20137 (2014).","journal-title":"BMC Gastroenterol."},{"key":"15430_CR3","doi-asserted-by":"publisher","first-page":"9749802","DOI":"10.1155\/2017\/9749802","volume":"2017","author":"X Li","year":"2017","unstructured":"Li, X., Guo, X., Ji, H., Yu, G. & Gao, P. Gallstones in Patients with Chronic Liver Diseases. BioMed research international \n                           2017, 9749802, https:\/\/doi.org\/10.1155\/2017\/9749802 (2017).","journal-title":"BioMed research international"},{"key":"15430_CR4","doi-asserted-by":"publisher","first-page":"16024","DOI":"10.1038\/nrdp.2016.24","volume":"2","author":"F Lammert","year":"2016","unstructured":"Lammert, F. et al. Gallstones. Nature reviews. Disease primers \n                           2, 16024, https:\/\/doi.org\/10.1038\/nrdp.2016.24 (2016).","journal-title":"Disease primers"},{"key":"15430_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-017-0662-1","volume":"19","author":"A Kalra","year":"2017","unstructured":"Kalra, A. et al. Overview of Coronary Heart Disease Risk Initiatives in South Asia. Current atherosclerosis reports \n                           19, 25, https:\/\/doi.org\/10.1007\/s11883-017-0662-1 (2017).","journal-title":"Current atherosclerosis reports"},{"key":"15430_CR6","doi-asserted-by":"publisher","unstructured":"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (London, England) 385, 117\u2013171, doi:https:\/\/doi.org\/10.1016\/s0140-6736(14)61682-2 (2015).","DOI":"10.1016\/s0140-6736(14)61682-2"},{"key":"15430_CR7","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1001\/archopht.121.4.519","volume":"121","author":"LR Van","year":"2003","unstructured":"Van, L. R., Klaver, C. C., Vingerling, J. R., Hofman, A. & de Jong, P. T. The risk and natural course of age-related maculopathy: follow-up at 6 1\/2 years in the Rotterdam study. Archives of Ophthalmology \n                           121, 519 (2003).","journal-title":"Archives of Ophthalmology"},{"key":"15430_CR8","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1076\/opep.8.4.251.1612","volume":"8","author":"BE Klein","year":"2001","unstructured":"Klein, B. E., Klein, R., Lee, K. E. & Jensen, S. C. Measures of obesity and age-related eye diseases. Ophthalmic Epidemiology \n                           8, 251 (2001).","journal-title":"Ophthalmic Epidemiology"},{"key":"15430_CR9","doi-asserted-by":"publisher","first-page":"Pc28","DOI":"10.7860\/jcdr\/2016\/22098.8736","volume":"10","author":"B Kharga","year":"2016","unstructured":"Kharga, B. et al. Obesity Not Necessary, Risk of Symptomatic Cholelithiasis Increases as a Function of BMI. Journal of clinical and diagnostic research: JCDR \n                           10, Pc28\u2013pc32, https:\/\/doi.org\/10.7860\/jcdr\/2016\/22098.8736 (2016).","journal-title":"Journal of clinical and diagnostic research: JCDR"},{"key":"15430_CR10","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1097\/HCO.0000000000000411","volume":"32","author":"A Jain","year":"2017","unstructured":"Jain, A., Puri, R. & Nair, D. R. South Asians: why are they at a higher risk for cardiovascular disease? Current opinion in cardiology \n                           32, 430\u2013436, https:\/\/doi.org\/10.1097\/hco.0000000000000411 (2017).","journal-title":"Current opinion in cardiology"},{"key":"15430_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04469-z","volume":"7","author":"SK Shukla","year":"2017","unstructured":"Shukla, S. K. et al. HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk. Scientific reports \n                           7, 4590, https:\/\/doi.org\/10.1038\/s41598-017-04469-z (2017).","journal-title":"Scientific reports"},{"key":"15430_CR12","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1055\/s-0042-113238","volume":"141","author":"KC Grotemeyer","year":"2016","unstructured":"Grotemeyer, K. C. & Lammert, F. [Gallstones - Causes and Consequences]. Deutsche medizinische Wochenschrift (1946) \n                           141, 1677\u20131682, https:\/\/doi.org\/10.1055\/s-0042-113238 (2016).","journal-title":"Deutsche medizinische Wochenschrift (1946)"},{"key":"15430_CR13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1442-9071.2004.00813.x","volume":"32","author":"P Mitchell","year":"2004","unstructured":"Mitchell, P., Wang, J. J., Smith, W. & Leeder, S. R. Smoking and the 5-year incidence of age-related maculopathy: the Blue Mountains Eye Study. Clinical & Experimental Ophthalmology \n                           32, 255\u2013258 (2004).","journal-title":"Clinical & Experimental Ophthalmology"},{"key":"15430_CR14","doi-asserted-by":"publisher","first-page":"e0173704","DOI":"10.1371\/journal.pone.0173704","volume":"12","author":"AE Bardach","year":"2017","unstructured":"Bardach, A. E., Caporale, J. E., Rubinstein, A. L. & Danaei, G. Impact of level and patterns of alcohol drinking on coronary heart disease and stroke burden in Argentina. PLoS One \n                           12, e0173704, https:\/\/doi.org\/10.1371\/journal.pone.0173704 (2017).","journal-title":"PLoS One"},{"key":"15430_CR15","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.ophtha.2007.07.031","volume":"115","author":"RE Hogg","year":"2008","unstructured":"Hogg, R. E. et al. Cardiovascular Disease and Hypertension Are Strong Risk Factors for Choroidal Neovascularization. Ophthalmology \n                           115, 1046 (2008).","journal-title":"Ophthalmology"},{"key":"15430_CR16","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1161\/ATVBAHA.116.307507","volume":"36","author":"Y Zheng","year":"2016","unstructured":"Zheng, Y. et al. Gallstones and Risk of Coronary Heart Disease: Prospective Analysis of 270\u2009000 Men and Women From 3 US Cohorts and Meta-Analysis. Arteriosclerosis Thrombosis & Vascular Biology \n                           36, 1997 (2016).","journal-title":"Arteriosclerosis Thrombosis & Vascular Biology"},{"key":"15430_CR17","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","volume":"25","author":"A Stang","year":"2010","unstructured":"Stang, A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. European journal of epidemiology \n                           25, 603\u2013605, https:\/\/doi.org\/10.1007\/s10654-010-9491-z (2010).","journal-title":"European journal of epidemiology"},{"key":"15430_CR18","unstructured":"Sutton, A. J. et al. Methods for meta-analysis in medical research. (2000)."},{"key":"15430_CR19","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins, J. P., Thompson, S. G., Deeks, J. J. & Altman, D. G. Measuring inconsistency in meta-analyses. British Medical Journal \n                           327, 557\u2013560 (2003).","journal-title":"British Medical Journal"},{"key":"15430_CR20","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"R Dersimonian","year":"1986","unstructured":"Dersimonian, R. & Laird, N. Meta-analysis in clinical trials. Controlled Clinical Trials \n                           7, 177\u2013188 (1986).","journal-title":"Controlled Clinical Trials"},{"key":"15430_CR21","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","volume":"56","author":"S Duval","year":"2000","unstructured":"Duval, S. & Tweedie, R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics \n                           56, 455 (2000).","journal-title":"Biometrics"},{"key":"15430_CR22","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"S Schnee","year":"1997","unstructured":"Schnee, S. et al. Bias in meta-analysis detected by a simple, graphical test. Bmj \n                           315, 629 (1997).","journal-title":"Bmj"},{"key":"15430_CR23","doi-asserted-by":"crossref","unstructured":"Sterne, J. A., Becker, B. J. & Egger, M. The funnel plot. Publication bias in meta-analysis: Prevention, assessment and adjustments, 75\u201398 (2005).","DOI":"10.1002\/0470870168.ch5"},{"key":"15430_CR24","doi-asserted-by":"crossref","unstructured":"Wang, J. et al. Relation of phosphodiesterase type 5 inhibitors and malignant melanoma: a meta-analysis and systematic review (2017).","DOI":"10.18632\/oncotarget.17518"},{"key":"15430_CR25","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1093\/oxfordjournals.aje.a113978","volume":"121","author":"EA Bortnichak","year":"1985","unstructured":"Bortnichak, E. A. et al. The association between cholesterol cholelithiasis and coronary heart disease in Framingham, Massachusetts. American Journal of Epidemiology \n                           121, 19\u201330 (1985).","journal-title":"American Journal of Epidemiology"},{"key":"15430_CR26","doi-asserted-by":"publisher","first-page":"185","DOI":"10.7326\/0003-4819-118-3-199302010-00005","volume":"118","author":"CH Grimaldi","year":"1993","unstructured":"Grimaldi, C. H. et al. Increased mortality with gallstone disease: results of a 20-year population-based survey in Pima Indians. Annals of internal medicine \n                           118, 185\u2013190 (1993).","journal-title":"Annals of internal medicine"},{"key":"15430_CR27","doi-asserted-by":"crossref","unstructured":"Lv, J. et al. Gallstone Disease and the Risk of Ischemic Heart Disease. Arteriosclerosis Thrombosis & Vascular Biology \n                           35 (2015).","DOI":"10.1161\/ATVBAHA.115.306043"},{"key":"15430_CR28","doi-asserted-by":"publisher","first-page":"e76448","DOI":"10.1371\/journal.pone.0076448","volume":"8","author":"H-YC Muideen Tunbosun Olaiya","year":"2013","unstructured":"Muideen Tunbosun Olaiya, H.-Y. C., Jiann-Shing, J., Li-Ming, L. & Fang-I, H. Significantly Increased Risk of Cardiovascular Disease among Patients with Gallstone Disease: A Population-Based Cohort Study. Plos One \n                           8, e76448 (2013).","journal-title":"Plos One"},{"key":"15430_CR29","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1053\/j.gastro.2010.10.060","volume":"140","author":"CE Ruhl","year":"2011","unstructured":"Ruhl, C. E. & Everhart, J. E. Gallstone Disease is Associated with Increased Mortality in the United States. Gastroenterology \n                           140, 508\u2013516 (2011).","journal-title":"Gastroenterology"},{"key":"15430_CR30","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.04.024","volume":"23","author":"CY Wei","year":"2014","unstructured":"Wei, C. Y. et al. Gallstone disease and the risk of stroke: a nationwide population-based study. Journal of Stroke & Cerebrovascular Diseases \n                           23, 1813\u20131820 (2014).","journal-title":"Journal of Stroke & Cerebrovascular Diseases"},{"key":"15430_CR31","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1177\/2047487313512218","volume":"22","author":"J Wirth","year":"2015","unstructured":"Wirth, J. et al. Presence of gallstones and the risk of cardiovascular diseases: The EPIC-Germany cohort study. European Journal of Preventive Cardiology \n                           22, 326 (2015).","journal-title":"European Journal of Preventive Cardiology"},{"key":"15430_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11906-015-0544-2","volume":"17","author":"JB Cohen","year":"2015","unstructured":"Cohen, J. B. & Cohen, D. L. Cardiovascular and Renal Effects of Weight Reduction in Obesity and the Metabolic Syndrome. Current Hypertension Reports \n                           17, 1\u20137 (2015).","journal-title":"Current Hypertension Reports"},{"key":"15430_CR33","first-page":"11","volume":"22","author":"H\u0130 Serin","year":"2017","unstructured":"Serin, H. \u0130. et al. The association between gallstone disease and plaque in the abdominopelvic arteries. Journal of Research in Medical Sciences the Official Journal of Isfahan University of Medical Sciences \n                           22, 11 (2017).","journal-title":"Journal of Research in Medical Sciences the Official Journal of Isfahan University of Medical Sciences"},{"key":"15430_CR34","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1111\/j.1572-0241.2005.50650_3.x","volume":"100","author":"MT Twickler","year":"2005","unstructured":"Twickler, M. T., Cramer, M. J. & van Erpecum, K. J. Insulin-like growth factor-1: a common metabolic pathway in the origin of both gallstones and coronary heart disease. American Journal of Gastroenterology \n                           100, 2363\u20132364 (2005).","journal-title":"American Journal of Gastroenterology"},{"key":"15430_CR35","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1080\/1025814021000036179","volume":"6","author":"A Geetha","year":"2002","unstructured":"Geetha, A. Evidence for Oxidative Stress in the Gall Bladder Mucosa of Gall Stone Patients. J Biochem Mol Biol Biophys \n                           6, 427\u2013432 (2002).","journal-title":"J Biochem Mol Biol Biophys"},{"key":"15430_CR36","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1089\/ars.2010.3739","volume":"15","author":"H Otani","year":"2011","unstructured":"Otani, H. Oxidative stress as pathogenesis of cardiovascular risk associated with metabolic syndrome. Antioxidants & Redox Signaling \n                           15, 1911 (2011).","journal-title":"Antioxidants & Redox Signaling"},{"key":"15430_CR37","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1161\/CIRCRESAHA.117.309715","volume":"120","author":"WH Tang","year":"2017","unstructured":"Tang, W. H., Kitai, T. & Hazen, S. L. Gut Microbiota in Cardiovascular Health and Disease. Circulation Research \n                           120, 1183 (2017).","journal-title":"Circulation Research"},{"key":"15430_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-669","volume":"14","author":"T Wu","year":"2013","unstructured":"Wu, T. et al. Gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study. BMC genomics \n                           14, 669, https:\/\/doi.org\/10.1186\/1471-2164-14-669 (2013).","journal-title":"BMC genomics"},{"key":"15430_CR39","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1161\/ATVBAHA.114.303034","volume":"34","author":"CD Byrne","year":"2014","unstructured":"Byrne, C. D. & Targher, G. Ectopic fat, insulin resistance, and nonalcoholic fatty liver disease: implications for cardiovascular disease. Arteriosclerosis Thrombosis & Vascular Biology \n                           34, 1155 (2014).","journal-title":"Arteriosclerosis Thrombosis & Vascular Biology"},{"key":"15430_CR40","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3109\/00365521.2014.894119","volume":"49","author":"MH Ahmed","year":"2014","unstructured":"Ahmed, M. H. & Ali, A. Nonalcoholic fatty liver disease and cholesterol gallstones: which comes first? Scandinavian Journal of Gastroenterology \n                           49, 521\u2013527 (2014).","journal-title":"Scandinavian Journal of Gastroenterology"},{"key":"15430_CR41","doi-asserted-by":"publisher","first-page":"e41183","DOI":"10.1371\/journal.pone.0041183","volume":"7","author":"AL Fracanzani","year":"2012","unstructured":"Fracanzani, A. L. et al. Gallstone Disease Is Associated with More Severe Liver Damage in Patients with Non-Alcoholic Fatty Liver Disease. Plos One \n                           7, e41183 (2012).","journal-title":"Plos One"},{"key":"15430_CR42","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1161\/ATVBAHA.115.306339","volume":"35","author":"G Targher","year":"2015","unstructured":"Targher, G. & Byrne, C. D. G. Disease and Increased Risk of Ischemic Heart Disease: Causal Association or Epiphenomenon? Arteriosclerosis, thrombosis, and vascular biology \n                           35, 2073\u20132075, https:\/\/doi.org\/10.1161\/atvbaha.115.306339 (2015).","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"15430_CR43","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.jdiacomp.2015.11.012","volume":"30","author":"D Aune","year":"2016","unstructured":"Aune, D. & Vatten, L. J. Diabetes mellitus and the risk of gallbladder disease: A systematic review and meta-analysis of prospective studies. Journal of diabetes and its complications \n                           30, 368\u2013373, https:\/\/doi.org\/10.1016\/j.jdiacomp.2015.11.012 (2016).","journal-title":"Journal of diabetes and its complications"},{"issue":"Suppl 2","key":"15430_CR44","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1097\/01.hjr.0000277983.23934.c9","volume":"14","author":"I Graham","year":"2007","unstructured":"Graham, I. et al. European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representa). European journal of cardiovascular prevention and rehabilitation: official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology \n                           14(Suppl 2), S1 (2007).","journal-title":"European journal of cardiovascular prevention and rehabilitation: official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology"},{"key":"15430_CR45","doi-asserted-by":"crossref","unstructured":"Murphy, M. O. & Loria, A. S. Sex-Specific Effects of Stress on Metabolic and Cardiovascular Disease: Are women at a higher risk? American Journal of Physiology Regulatory Integrative & Comparative Physiology, ajpregu.00185.02016 (2017).","DOI":"10.1152\/ajpregu.00185.2016"},{"issue":"Suppl","key":"15430_CR46","first-page":"48","volume":"42","author":"N Mendez Sanchez","year":"1990","unstructured":"Mendez Sanchez, N., Uribe Esquivel, M., Jessurun Solomou, J., Cervera Ceballos, E. & Bosques Padilla, F. [Epidemiology of gallstone disease in Mexico]. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion \n                           42(Suppl), 48\u201352 (1990).","journal-title":"Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion"},{"key":"15430_CR47","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1111\/j.1478-3231.2010.02361.x","volume":"31","author":"L Amigo","year":"2011","unstructured":"Amigo, L. et al. Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice. Liver International Official Journal of the International Association for the Study of the Liver \n                           31, 52\u201364 (2011).","journal-title":"Liver International Official Journal of the International Association for the Study of the Liver"},{"key":"15430_CR48","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1056\/NEJM197312062892302","volume":"289","author":"HR Almond","year":"1973","unstructured":"Almond, H. R. et al. Bile acid pools, kinetics and biliary lipid composition before and after cholecystectomy. N Engl J Med \n                           289, 1213\u20131216 (1973).","journal-title":"N Engl J Med"},{"key":"15430_CR49","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1136\/gut.19.7.640","volume":"19","author":"E Roda","year":"1978","unstructured":"Roda, E. et al. Enterohepatic circulation of bile acids after cholecystectomy. Gut \n                           19, 640 (1978).","journal-title":"Gut"},{"key":"15430_CR50","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1002\/hep.24702","volume":"55","author":"SJ Zweers","year":"2012","unstructured":"Zweers, S. J. et al. The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract. Hepatology \n                           55, 575 (2012).","journal-title":"Hepatology"},{"key":"15430_CR51","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1111\/1758-2229.12319","volume":"7","author":"N Keren","year":"2015","unstructured":"Keren, N. et al. Interactions between the intestinal microbiota and bile acids in gallstones patients. Environmental microbiology reports \n                           7, 874\u2013880, https:\/\/doi.org\/10.1111\/1758-2229.12319 (2015).","journal-title":"Environmental microbiology reports"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-15430-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-15430-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-15430-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T08:22:35Z","timestamp":1671783755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-15430-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,8]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["15430"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-15430-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,8]]},"assertion":[{"value":"14 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"15104"}}