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Hence in the present study, the potential utility of (<jats:italic>E<\/jats:italic>)-5-benzylidenedihydrofuran-2(3\u2009<jats:italic>H<\/jats:italic>)-one (compound-<jats:bold>6<\/jats:bold>) was explored as an effective anticryptococcal compound with immunomodulatory potential. The efficacy of compound-<jats:bold>6<\/jats:bold> in pulmonary cryptococosis model using H99 strain was investigated. The effective dose was found to provide 100% survival, with a significant reduction of yeast burden in lungs and brain. The biodistribution analysis provided evidence for the presence of higher concentration of compound-<jats:bold>6<\/jats:bold> in major organs including lungs and brain. In addition, compound-<jats:bold>6<\/jats:bold> treated mice had significantly higher expression of IL-6, IL-4 and IFN-\u03b3 in lung and brain. Similarly, elevated expression of TNF-\u03b1, IL-\u03b21 and IL-12 were observed in lungs, suggesting the protective host response against <jats:italic>C. neoformans<\/jats:italic>. The reduction and clearance of fungal load in systemic organs and mouse survival are notable results to confirm the ability of compound-<jats:bold>6<\/jats:bold> to treat cryptococcosis. In conclusion, the low molecular weight (174\u2009Da), lipophilicity, its ability to cross blood brain barrier, and facilitating modulation of cytokine expression are the added advantages of compound-<jats:bold>6<\/jats:bold> to combat against disseminated cryptococosis.<\/jats:p>","DOI":"10.1038\/s41598-017-15500-8","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T10:47:25Z","timestamp":1510051645000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exploration of Antifungal and Immunomodulatory Potentials of a Furanone Derivative to Rescue Disseminated Cryptococosis in Mice"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9924-933X","authenticated-orcid":false,"given":"Sudarshan Singh","family":"Rathore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthukrishnan","family":"Isravel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sridharan","family":"Vellaisamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Raj","family":"Chellappan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalitha","family":"Cheepurupalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiagarajan","family":"Raman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayapradha","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,13]]},"reference":[{"key":"15500_CR1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nrmicro.2015.6","volume":"14","author":"RC May","year":"2015","unstructured":"May, R. 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