{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:44:05Z","timestamp":1740163445451,"version":"3.37.3"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:00:00Z","timestamp":1510617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to examine the relationship between measurements related to heart sounds and the origin of ventricular arrhythmia. We retrospectively evaluated 45 patients undergoing catheter ablation with contemporaneous digital acoustic cardiography of the first heart sound (S1) and the second heart sound (S2). The patients with baseline wide QRS morphology (&gt;120 ms or aberrant conduction), heart failure, valvular heart disease, chronic pulmonary disease, and obesity were excluded. Ventricular arrhythmias from the left ventricle had an increased S1 complexity score and S1 duration in comparison to adjacent sinus beats. On the other hand, ventricular arrhythmia from right ventricle had decreased S1 complexity score and S1 duration in comparison to adjacent sinus beats. The difference of S1 (\u0394S1) parameters between premature ventricular complex and sinus beat was significantly smaller in right ventricular arrhythmia group compared with and left ventricular arrhythmia group. For predicting the origin of ventricular arrhythmia, the \u0394S1 duration provide better predictive accuracy (sensitivity: 100%, specificity: 100%, cutoff value: \u22121.28 ms) in comparison to \u0394S1 complexity score (sensitivity 71.4%, specificity 75.0%, cutoff value: \u22120.13). The change of S1 complexity and duration determined from acoustic cardiography could accurately predict the ventricular arrhythmia origin.<\/jats:p>","DOI":"10.1038\/s41598-017-15573-5","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T10:03:53Z","timestamp":1510135433000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predicting the Origin of Ventricular Arrhythmia Using Acoustic Cardiography"],"prefix":"10.1038","volume":"7","author":[{"given":"Chin-Yu","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Lin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yenn-Jiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Wei","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Feng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tze-Fan","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa-Po","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta-Chuan","family":"Tuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo-Nan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Ting","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail Louise D.","family":"Te","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Min","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Hsien","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsing-Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Yung","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoang Quang","family":"Minh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0764-7862","authenticated-orcid":false,"given":"Simon","family":"Salim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Chung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Ann","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,14]]},"reference":[{"key":"15573_CR1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1067\/mhj.2002.120298","volume":"143","author":"RJ Simpson Jr.","year":"2002","unstructured":"Simpson, R. J. Jr. et al. Prevalence of premature ventricular contractions in a population of African American and white men and women: the Atherosclerosis Risk in Communities (ARIC) study. American heart journal \n                           143, 535\u2013540 (2002).","journal-title":"American heart journal"},{"key":"15573_CR2","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1136\/hrt.30.6.757","volume":"30","author":"A Oriol","year":"1968","unstructured":"Oriol, A., Papp, O. & Sanz, G. Splitting of second heart sound in ventricular ectopic beats. Br Heart J \n                           30, 757\u2013764 (1968).","journal-title":"Br Heart J"},{"key":"15573_CR3","doi-asserted-by":"publisher","first-page":"E324","DOI":"10.1532\/HSF98.20101030","volume":"13","author":"C Bara","year":"2010","unstructured":"Bara, C. et al. Echocardiographic detection of cardiac ectopy: a possible alternative to electrophysiological mapping? The heart surgery forum \n                           13, E324\u2013327, https:\/\/doi.org\/10.1532\/HSF98.20101030 (2010).","journal-title":"The heart surgery forum"},{"key":"15573_CR4","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1111\/jce.12237","volume":"24","author":"MD Hutchinson","year":"2013","unstructured":"Hutchinson, M. D. & Garcia, F. C. An organized approach to the localization, mapping, and ablation of outflow tract ventricular arrhythmias. Journal of cardiovascular electrophysiology \n                           24, 1189\u20131197, https:\/\/doi.org\/10.1111\/jce.12237 (2013).","journal-title":"Journal of cardiovascular electrophysiology"},{"key":"15573_CR5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.hrthm.2015.08.030","volume":"13","author":"CY Lin","year":"2016","unstructured":"Lin, C. Y. et al. Radiofrequency catheter ablation of ventricular arrhythmias originating from the continuum between the aortic sinus of Valsalva and the left ventricular summit: Electrocardiographic characteristics and correlative anatomy. Heart rhythm \n                           13, 111\u2013121, https:\/\/doi.org\/10.1016\/j.hrthm.2015.08.030 (2016).","journal-title":"Heart rhythm"},{"key":"15573_CR6","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1161\/01.CIR.63.2.429","volume":"63","author":"GW Burggraf","year":"1981","unstructured":"Burggraf, G. W. The first heart sound in left bundle branch block: an echophonocardiographic study. Circulation \n                           63, 429\u2013435 (1981).","journal-title":"Circulation"},{"key":"15573_CR7","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1136\/hrt.41.6.637","volume":"41","author":"N Brooks","year":"1979","unstructured":"Brooks, N., Leech, G. & Leatham, A. Complete right bundle-branch block: echophonocardiographic study of first heart sound and right ventricular contraction times. British heart journal \n                           41, 637\u2013646 (1979).","journal-title":"British heart journal"},{"key":"15573_CR8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1536\/ihj.28.143","volume":"28","author":"AA Luisada","year":"1987","unstructured":"Luisada, A. A. The first heart sound in normal and pathological conditions. Japanese heart journal \n                           28, 143\u2013156 (1987).","journal-title":"Japanese heart journal"},{"key":"15573_CR9","unstructured":"Erne, P. Beyond auscultation\u2013acoustic cardiography in the diagnosis and assessment of cardiac disease. Swiss medical weekly \n                           138, 439\u2013452, doi:2008\/31\/smw-12308 (2008)."},{"key":"15573_CR10","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1161\/01.RES.2.1.48","volume":"2","author":"RC Little","year":"1954","unstructured":"Little, R. C., Hilton, J. G. & Schaefer, R. D. The first heart sound in normal and ectopic ventricular contractions; mechanism of closure of the A-V valves. Circ Res \n                           2, 48\u201352 (1954).","journal-title":"Circ Res"},{"key":"15573_CR11","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/0002-9149(70)90591-6","volume":"25","author":"AA Luisada","year":"1970","unstructured":"Luisada, A. A., Gagnon, G. & Ikeda, H. The first heart sound and the dynamic events in ventricular ectopic beats and in paced beats. Am J Cardiol \n                           25, 529\u2013534 (1970).","journal-title":"Am J Cardiol"},{"key":"15573_CR12","doi-asserted-by":"publisher","unstructured":"Chan, W. et al. Haemodynamic and structural correlates of the first and second heart sounds in pulmonary arterial hypertension: an acoustic cardiography cohort study. BMJ open \n                           3, https:\/\/doi.org\/10.1136\/bmjopen-2013-002660 (2013).","DOI":"10.1136\/bmjopen-2013-002660"},{"key":"15573_CR13","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.cardfail.2008.03.011","volume":"14","author":"S Efstratiadis","year":"2008","unstructured":"Efstratiadis, S. & Michaels, A. D. Computerized acoustic cardiographic electromechanical activation time correlates with invasive and echocardiographic parameters of left ventricular contractility. Journal of cardiac failure \n                           14, 577\u2013582, https:\/\/doi.org\/10.1016\/j.cardfail.2008.03.011 (2008).","journal-title":"Journal of cardiac failure"},{"key":"15573_CR14","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1001\/jama.293.18.2238","volume":"293","author":"GM Marcus","year":"2005","unstructured":"Marcus, G. M. et al. Association between phonocardiographic third and fourth heart sounds and objective measures of left ventricular function. Jama \n                           293, 2238\u20132244, https:\/\/doi.org\/10.1001\/jama.293.18.2238 (2005).","journal-title":"Jama"},{"issue":"Suppl 1","key":"15573_CR15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1527-5299.2006.05769.x","volume":"12","author":"M Roos","year":"2006","unstructured":"Roos, M., Toggweiler, S., Zuber, M., Jamshidi, P. & Erne, P. Acoustic cardiographic parameters and their relationship to invasive hemodynamic measurements in patients with left ventricular systolic dysfunction. Congestive heart failure \n                           12(Suppl 1), 19\u201324 (2006).","journal-title":"Congestive heart failure"},{"key":"15573_CR16","first-page":"963","volume":"16","author":"T Mikawa","year":"1986","unstructured":"Mikawa, T. et al. Mitral component of the first heart sound in complete left bundle branch block: the mechanism of the decreased intensity. Journal of cardiography \n                           16, 963\u2013976 (1986).","journal-title":"Journal of cardiography"},{"key":"15573_CR17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0033-0620(67)80011-2","volume":"9","author":"JK Perloff","year":"1967","unstructured":"Perloff, J. K. Auscultatory and phonocardiographic manifestations of pulmonary hypertension. Progress in cardiovascular diseases \n                           9, 303\u2013340 (1967).","journal-title":"Progress in cardiovascular diseases"},{"key":"15573_CR18","unstructured":"Felner, J. M. In Clinical Methods: The History, Physical, and Laboratory Examinations (eds H. K. Walker, W. D. Hall, & J. W. Hurst) (1990)."},{"key":"15573_CR19","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1161\/CIRCEP.113.000682","volume":"6","author":"BP Betensky","year":"2013","unstructured":"Betensky, B. P. et al. Characterization of trans-septal activation during septal pacing: criteria for identification of intramural ventricular tachycardia substrate in nonischemic cardiomyopathy. Circ Arrhythm Electrophysiol \n                           6, 1123\u20131130, https:\/\/doi.org\/10.1161\/CIRCEP.113.000682 (2013).","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"15573_CR20","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0002-9343(57)90194-8","volume":"23","author":"E Braunwald","year":"1957","unstructured":"Braunwald, E. & Morrow, A. G. Sequence of ventricular contraction in human bundle branch block; a study based on simultaneous catheterization of both ventricles. Am J Med \n                           23, 205\u2013211 (1957).","journal-title":"Am J Med"},{"key":"15573_CR21","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/0002-9149(62)90173-X","volume":"10","author":"MG Bourassa","year":"1962","unstructured":"Bourassa, M. G., Boiteau, G. M. & Allenstein, B. J. Hemodynamic studies during intermittent left bundle branch block. Am J Cardiol \n                           10, 792\u2013799 (1962).","journal-title":"Am J Cardiol"},{"key":"15573_CR22","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/0002-8703(69)90509-2","volume":"78","author":"RJ Adolph","year":"1969","unstructured":"Adolph, R. J., Fowler, N. O. & Tanaka, K. Prolongation of isovolumic contraction time in left bundle branch block. Am Heart J \n                           78, 585\u2013591 (1969).","journal-title":"Am Heart J"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-15573-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-15573-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-15573-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T13:30:11Z","timestamp":1671802211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-15573-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,14]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["15573"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-15573-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2017,11,14]]},"assertion":[{"value":"4 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"15490"}}