{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T21:02:07Z","timestamp":1774126927328,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T00:00:00Z","timestamp":1510790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T00:00:00Z","timestamp":1510790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the efficacy of dose de-escalation to the normal larynx using conformal radiotherapy (CRT) for T1\/T2 glottic cancer. For conventional RT (2DRT, n\u2009=\u200938), the laryngeal box received a median equivalent dose in 2\u2009Gy fractions (EQD2) of 66\u2009Gy. For CRT (n\u2009=\u200942; 3D-CRT, 20; intensity-modulated RT, 22), clinical target volume (CTV)1 (gross tumor with a 3-mm margin) and CTV2 (laryngeal box) received median EQD2s of 66.6\u2009Gy and 52.2\u2009Gy, respectively. With a 71-month median follow-up, five-year local control and overall survival rates for 2DRT vs. CRT were 88.1% vs. 95.1% (p\u2009=\u20090.405) and 94.7% vs. 90.7% (p\u2009=\u20090.102), respectively. Grade 2 and 3 pharyngitis rates were 52.6% and 5.3% for 2DRT vs. 35.7% and 2.4% for CRT (p\u2009=\u20090.121). Grade 2 and 3 dermatitis rates\u00a0were 42.1% and 2.6% for 2DRT vs. 35.7% and 0% for CRT (p\u2009=\u20090.013). The maximum phonation time increased from 12.1\u2009\u00b1\u20097.1 to 14.0\u2009\u00b1\u20096.6\u2009seconds after 2DRT (p\u2009=\u20090.375) and from 12.0\u2009\u00b1\u20095.5 to 13.8\u2009\u00b1\u200910.1\u2009seconds after CRT (p\u2009=\u20090.313). Fundamental frequency decreased from 150.6\u2009\u00b1\u200940.3 to 121.9\u2009\u00b1\u200930.2\u2009Hz after 2DRT (p\u2009=\u20090.039) and from 138.5\u2009\u00b1\u200931.9 to 126.1\u2009\u00b1\u200923.7\u2009Hz after CRT (p\u2009=\u20090.058). CRT can effectively de-escalate the normal larynx dose while maintaining oncologic outcome and voice quality.<\/jats:p>","DOI":"10.1038\/s41598-017-15974-6","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T14:36:59Z","timestamp":1510324619000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Dose de-escalation to the normal larynx using conformal radiotherapy reduces toxicity while maintaining oncologic outcome for T1\/T2 glottic cancer"],"prefix":"10.1038","volume":"7","author":[{"given":"Jun Won","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Kwon","family":"Byeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Shik","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ik Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,16]]},"reference":[{"key":"15974_CR1","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1002\/ijc.25516","volume":"127","author":"J Ferlay","year":"2010","unstructured":"Ferlay, J. et al. 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The error has been fixed in the paper.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"15732"}}