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TRPA1 activators have been generally recognized as noxious, however, foods and beverages containing TRPA1 activators are preferably consumed; the reasons for this discrepancy are not well understood. We demonstrate that TRPA1 is involved in the stimulatory appetite control mechanism. \u03b2-Eudesmol is an oxygenated sesquiterpene contained in medicinal or edible plants which activates TRPA1. Oral administration of \u03b2-eudesmol brought significant increments in food intake in rats and elevated plasma ghrelin levels. Gastric vagal nerve activity (GVNA) has been reported to affect feeding behavior. <jats:italic>In vivo<\/jats:italic> electrophysiological measurement of GVNA revealed that oral-ingestion of \u03b2-eudesmol significantly increased GVNA. This GVNA elevation was eliminated by TRPA1 inhibitor (HC-030031) treatment prior to \u03b2-eudesmol administration. The physiological effects of \u03b2-eudesmol, for example, incremental increase in food intake, ghrelin elevation and activation of GVNA, were significantly reduced in TRPA1 knockout rats. Our results indicated that \u03b2-eudesmol stimulates an increase in appetite through TRPA1, and suggests why TRPA1 activator containing foods and beverages are preferably consumed.<\/jats:p>","DOI":"10.1038\/s41598-017-16150-6","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T10:57:14Z","timestamp":1510570634000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["\u03b2-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous system"],"prefix":"10.1038","volume":"7","author":[{"given":"Kazuaki","family":"Ohara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rena","family":"Ohya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunitoshi","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuya","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,17]]},"reference":[{"key":"16150_CR1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev-cellbio-101011-155833","volume":"29","author":"D Julius","year":"2013","unstructured":"Julius, D. 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TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells. Proceedings of the National Academy of Sciences of the United States of America \n                           106, 3408\u20133413 (2009).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"16150_CR8","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nature02282","volume":"427","author":"SE Jordt","year":"2004","unstructured":"Jordt, S. E. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature \n                           427, 260\u2013265 (2004).","journal-title":"Nature"},{"key":"16150_CR9","doi-asserted-by":"publisher","first-page":"9874","DOI":"10.1523\/JNEUROSCI.2221-07.2007","volume":"27","author":"Y Karashima","year":"2007","unstructured":"Karashima, Y. et al. Bimodal action of menthol on the transient receptor potential channel TRPA1. 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