{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:14:25Z","timestamp":1791756865028,"version":"4.3.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The gastric microbiome has been proposed as an etiological factor in gastric carcinogenesis. We compared the gastric microbiota in subjects presenting with gastric cancer (GC, n\u2009=\u200912) and controls (functional dyspepsia (FD), n\u2009=\u200920) from a high GC risk population in Singapore and Malaysia. cDNA from 16S rRNA transcripts were amplified (515F-806R) and sequenced using Illumina MiSeq 2\u2009\u00d7\u2009250\u2009bp chemistry. Increased richness and phylogenetic diversity but not Shannon\u2019s diversity was found in GC as compared to controls. nMDS clustered GC and FD subjects separately, with PERMANOVA confirming a significant difference between the groups.\n                    <jats:italic>H. pylori<\/jats:italic>\n                    serological status had a significant impact on gastric microbiome \u03b1-diversity and composition. Several bacterial taxa were enriched in GC, including\n                    <jats:italic>Lactococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Veilonella<\/jats:italic>\n                    , and\n                    <jats:italic>Fusobacteriaceae<\/jats:italic>\n                    (\n                    <jats:italic>Fusobacterium<\/jats:italic>\n                    and\n                    <jats:italic>Leptotrichia<\/jats:italic>\n                    ). Prediction of bacterial metabolic contribution indicated that serological status had a significant impact on metabolic function, while carbohydrate digestion and pathways were enriched in GC. Our findings highlight three mechanisms of interest in GC, including enrichment of pro-inflammatory oral bacterial species, increased abundance of lactic acid producing bacteria, and enrichment of short chain fatty acid production pathways.\n                  <\/jats:p>","DOI":"10.1038\/s41598-017-16289-2","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T10:27:08Z","timestamp":1510741628000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":234,"title":["Dysbiosis of the microbiome in gastric carcinogenesis"],"prefix":"10.1038","volume":"7","author":[{"given":"Natalia","family":"Casta\u00f1o-Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khean-Lee","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwong Ming","family":"Fock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazel M.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem O.","family":"Kaakoush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"16289_CR1","unstructured":"Ferlay, J. et al. 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