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A theoretical model that included prenatal factors (socioeconomic status, pregestational body mass index-BMI, soft drink and junk food consumption), birth factors (gestational age, smoking and diseases during pregnancy, birth weight and type of delivery), first year of life factors (breastfeeding, environmental aeroallergens and respiratory diseases) and BMI z-score in the second year of life, was analyzed by structural equation modeling. High pregestational BMI, high soft drink consumption, cesarean section without labor, chill in the first three months of life, carpeted floor and child\u2019s exposure to tobacco were associated with higher values of \u201cChildhood Asthma Symptoms\u201d. In contrast, high birth weight, breastfeeding and infant\u2019s age were associated with lower values of \u201cChildhood Asthma Symptoms\u201d. These findings support the hypothesis that environmental factors that are present before conception and up to the first 1000 days of life are associated with asthma.<\/jats:p>","DOI":"10.1038\/s41598-017-16295-4","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T11:21:34Z","timestamp":1510831294000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The First 1000 Days of Life Factors Associated with \u201cChildhood Asthma Symptoms\u201d: Brisa Cohort, Brazil"],"prefix":"10.1038","volume":"7","author":[{"given":"Joelma Ximenes Prado Teixeira","family":"Nascimento","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0041-7618","authenticated-orcid":false,"given":"Cecilia Claudia Costa","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ros\u00e2ngela Fernandes Lucena","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa Seabra Soares","family":"de Britto Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda Maria Ferreira","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Lopes","family":"Padilha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane Cunha","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elcio Oliveira","family":"Vianna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heloisa","family":"Bettiol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Augusto Moura Da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"16295_CR1","unstructured":"World Health Organization (WHO). 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