{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:33:31Z","timestamp":1792798411213,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T00:00:00Z","timestamp":1511481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A majority of night shift workers have their circadian rhythms misaligned to their atypical schedule. While bright light exposure at night is known to reset the human central circadian clock, the behavior of peripheral clocks under conditions of shift work is more elusive. The aim of the present study was to quantify the resetting effects of bright light exposure on both central (plasma cortisol and melatonin) and peripheral clocks markers (clock gene expression in peripheral blood mononuclear cells, PBMCs) in subjects living at night. Eighteen healthy subjects were enrolled to either a control (dim light) or a bright light group. Blood was sampled at baseline and on the 4<jats:sup>th<\/jats:sup> day of simulated night shift. In response to a night-oriented schedule, the phase of <jats:italic>PER1<\/jats:italic> and <jats:italic>BMAL1<\/jats:italic> rhythms in PBMCs was delayed by ~2.5\u20133\u2009h (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009<jats:italic>0.05<\/jats:italic>), while no shift was observed for the other clock genes and the central markers. Three cycles of 8-h bright light induced significant phase delays (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) of ~7\u20139\u2009h for central and peripheral markers, except <jats:italic>BMAL1<\/jats:italic> (advanced by\u2009+5h29; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009<jats:italic>0.05<\/jats:italic>). Here, we demonstrate in humans a lack of peripheral clock adaptation under a night-oriented schedule and a rapid resetting effect of nocturnal bright light exposure on peripheral clocks.<\/jats:p>","DOI":"10.1038\/s41598-017-16429-8","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T14:54:20Z","timestamp":1511189660000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Rapid resetting of human peripheral clocks by phototherapy during simulated night shift work"],"prefix":"10.1038","volume":"7","author":[{"given":"Marc","family":"Cuesta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Boudreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Cermakian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane B.","family":"Boivin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,24]]},"reference":[{"key":"16429_CR1","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.sleep.2007.03.015","volume":"8","author":"DB Boivin","year":"2007","unstructured":"Boivin, D. B., Tremblay, G. M. & James, F. O. Working on atypical schedules. Sleep medicine \n                           8, 578\u2013589, https:\/\/doi.org\/10.1016\/j.sleep.2007.03.015 (2007).","journal-title":"Sleep medicine"},{"key":"16429_CR2","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1136\/oem.2006.027367","volume":"63","author":"A Pietroiusti","year":"2006","unstructured":"Pietroiusti, A. et al. Shift work increases the frequency of duodenal ulcer in H pylori infected workers. Occup Environ Med \n                           63, 773\u2013775, https:\/\/doi.org\/10.1136\/oem.2006.027367 (2006).","journal-title":"Occup Environ Med"},{"key":"16429_CR3","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.acvd.2011.09.004","volume":"104","author":"Y Esquirol","year":"2011","unstructured":"Esquirol, Y. et al. Shift work and cardiovascular risk factors: new knowledge from the past decade. Arch Cardiovasc Dis \n                           104, 636\u2013668, https:\/\/doi.org\/10.1016\/j.acvd.2011.09.004 (2011).","journal-title":"Arch Cardiovasc Dis"},{"key":"16429_CR4","doi-asserted-by":"publisher","first-page":"112","DOI":"10.5491\/SHAW.2010.1.2.112","volume":"1","author":"G Costa","year":"2010","unstructured":"Costa, G. Shift work and health: current problems and preventive actions. Saf Health Work \n                           1, 112\u2013123, https:\/\/doi.org\/10.5491\/SHAW.2010.1.2.112 (2010).","journal-title":"Saf Health Work"},{"key":"16429_CR5","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.patbio.2014.08.001","volume":"62","author":"DB Boivin","year":"2014","unstructured":"Boivin, D. B. & Boudreau, P. Impacts of shift work on sleep and circadian rhythms. Pathol Biol (Paris) \n                           62, 292\u2013301, https:\/\/doi.org\/10.1016\/j.patbio.2014.08.001 (2014).","journal-title":"Pathol Biol (Paris)"},{"key":"16429_CR6","doi-asserted-by":"publisher","first-page":"4453","DOI":"10.1073\/pnas.0808180106","volume":"106","author":"FA Scheer","year":"2009","unstructured":"Scheer, F. A., Hilton, M. F., Mantzoros, C. S. & Shea, S. A. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci USA \n                           106, 4453\u20134458, https:\/\/doi.org\/10.1073\/pnas.0808180106 (2009).","journal-title":"Proc Natl Acad Sci USA"},{"key":"16429_CR7","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.4049\/jimmunol.1502422","volume":"196","author":"M Cuesta","year":"2016","unstructured":"Cuesta, M., Boudreau, P., Dubeau-Laramee, G., Cermakian, N. & Boivin, D. B. Simulated Night Shift Disrupts Circadian Rhythms of Immune Functions in Humans. Journal of immunology \n                           196, 2466\u20132475, https:\/\/doi.org\/10.4049\/jimmunol.1502422 (2016).","journal-title":"Journal of immunology"},{"key":"16429_CR8","doi-asserted-by":"publisher","first-page":"20541","DOI":"10.1073\/pnas.1006749107","volume":"107","author":"FA Scheer","year":"2010","unstructured":"Scheer, F. A. et al. Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci USA \n                           107, 20541\u201320546, https:\/\/doi.org\/10.1073\/pnas.1006749107 (2010).","journal-title":"Proc Natl Acad Sci USA"},{"key":"16429_CR9","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1177\/0748730406293889","volume":"21","author":"M Stratmann","year":"2006","unstructured":"Stratmann, M. & Schibler, U. Properties, entrainment, and physiological functions of mammalian peripheral oscillators. J Biol Rhythms \n                           21, 494\u2013506, https:\/\/doi.org\/10.1177\/0748730406293889 (2006).","journal-title":"J Biol Rhythms"},{"issue":"Suppl 2","key":"16429_CR10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1467-789X.2009.00660.x","volume":"10","author":"N Cermakian","year":"2009","unstructured":"Cermakian, N. & Boivin, D. B. The regulation of central and peripheral circadian clocks in humans. Obes Rev \n                           10(Suppl 2), 25\u201336, https:\/\/doi.org\/10.1111\/j.1467-789X.2009.00660.x (2009).","journal-title":"Obes Rev"},{"key":"16429_CR11","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/B978-0-12-387690-4.00006-4","volume":"74","author":"PL Lowrey","year":"2011","unstructured":"Lowrey, P. L. & Takahashi, J. S. Genetics of circadian rhythms in Mammalian model organisms. Adv Genet \n                           74, 175\u2013230, https:\/\/doi.org\/10.1016\/B978-0-12-387690-4.00006-4 (2011).","journal-title":"Adv Genet"},{"key":"16429_CR12","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1177\/0748730402238238","volume":"17","author":"DB Boivin","year":"2002","unstructured":"Boivin, D. B. & James, F. O. Circadian adaptation to night-shift work by judicious light and darkness exposure. J Biol Rhythms \n                           17, 556\u2013567 (2002).","journal-title":"J Biol Rhythms"},{"key":"16429_CR13","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3109\/07420528.2012.675257","volume":"29","author":"DB Boivin","year":"2012","unstructured":"Boivin, D. B., Boudreau, P., James, F. O. & Kin, N. M. Photic resetting in night-shift work: impact on nurses\u2019 sleep. Chronobiol Int \n                           29, 619\u2013628, https:\/\/doi.org\/10.3109\/07420528.2012.675257 (2012).","journal-title":"Chronobiol Int"},{"key":"16429_CR14","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3109\/07420528.2012.675252","volume":"29","author":"DB Boivin","year":"2012","unstructured":"Boivin, D. B., Boudreau, P. & Tremblay, G. M. Phototherapy and orange-tinted goggles for night-shift adaptation of police officers on patrol. Chronobiol Int \n                           29, 629\u2013640, https:\/\/doi.org\/10.3109\/07420528.2012.675252 (2012).","journal-title":"Chronobiol Int"},{"key":"16429_CR15","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1093\/sleep\/30.11.1427","volume":"30","author":"FO James","year":"2007","unstructured":"James, F. O., Cermakian, N. & Boivin, D. B. Circadian rhythms of melatonin, cortisol, and clock gene expression during simulated night shift work. Sleep \n                           30, 1427\u20131436 (2007).","journal-title":"Sleep"},{"key":"16429_CR16","doi-asserted-by":"publisher","first-page":"15643","DOI":"10.1073\/pnas.1003878107","volume":"107","author":"M Akashi","year":"2010","unstructured":"Akashi, M. et al. Noninvasive method for assessing the human circadian clock using hair follicle cells. Proc Natl Acad Sci USA \n                           107, 15643\u201315648, https:\/\/doi.org\/10.1073\/pnas.1003878107 (2010).","journal-title":"Proc Natl Acad Sci USA"},{"key":"16429_CR17","doi-asserted-by":"publisher","first-page":"E682","DOI":"10.1073\/pnas.1316335111","volume":"111","author":"SN Archer","year":"2014","unstructured":"Archer, S. N. et al. Mistimed sleep disrupts circadian regulation of the human transcriptome. Proceedings of the National Academy of Sciences of the United States of America \n                           111, E682\u2013691, https:\/\/doi.org\/10.1073\/pnas.1316335111 (2014).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"16429_CR18","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1080\/07420520701800736","volume":"24","author":"FO James","year":"2007","unstructured":"James, F. O., Boivin, D. B., Charbonneau, S., Belanger, V. & Cermakian, N. Expression of clock genes in human peripheral blood mononuclear cells throughout the sleep\/wake and circadian cycles. Chronobiol Int \n                           24, 1009\u20131034, https:\/\/doi.org\/10.1080\/07420520701800736 (2007).","journal-title":"Chronobiol Int"},{"key":"16429_CR19","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1093\/sleep\/31.5.608","volume":"31","author":"SN Archer","year":"2008","unstructured":"Archer, S. N., Viola, A. U., Kyriakopoulou, V., von Schantz, M. & Dijk, D. J. Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes. Sleep \n                           31, 608\u2013617 (2008).","journal-title":"Sleep"},{"key":"16429_CR20","doi-asserted-by":"publisher","first-page":"901","DOI":"10.3109\/07420528.2013.784773","volume":"30","author":"K Ackermann","year":"2013","unstructured":"Ackermann, K. et al. Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans. Chronobiol Int \n                           30, 901\u2013909, https:\/\/doi.org\/10.3109\/07420528.2013.784773 (2013).","journal-title":"Chronobiol Int"},{"key":"16429_CR21","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1096\/fj.14-265686","volume":"29","author":"M Cuesta","year":"2015","unstructured":"Cuesta, M., Cermakian, N. & Boivin, D. B. Glucocorticoids entrain molecular clock components in human peripheral cells. FASEB journal: official publication of the Federation of American Societies for Experimental Biology \n                           29, 1360\u20131370, https:\/\/doi.org\/10.1096\/fj.14-265686 (2015).","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"key":"16429_CR22","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s00109-005-0697-6","volume":"83","author":"M Teboul","year":"2005","unstructured":"Teboul, M. et al. Atypical patterns of circadian clock gene expression in human peripheral blood mononuclear cells. J Mol Med (Berl) \n                           83, 693\u2013699, https:\/\/doi.org\/10.1007\/s00109-005-0697-6 (2005).","journal-title":"J Mol Med (Berl)"},{"key":"16429_CR23","doi-asserted-by":"publisher","first-page":"E1132","DOI":"10.1073\/pnas.1217154110","volume":"110","author":"CS Moller-Levet","year":"2013","unstructured":"Moller-Levet, C. S. et al. Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome. Proc Natl Acad Sci USA \n                           110, E1132\u20131141, https:\/\/doi.org\/10.1073\/pnas.1217154110 (2013).","journal-title":"Proc Natl Acad Sci USA"},{"key":"16429_CR24","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1177\/0748730415611761","volume":"31","author":"K Lech","year":"2016","unstructured":"Lech, K. et al. Dissecting Daily and Circadian Expression Rhythms of Clock-Controlled Genes in Human Blood. J Biol Rhythms \n                           31, 68\u201381, https:\/\/doi.org\/10.1177\/0748730415611761 (2016).","journal-title":"J Biol Rhythms"},{"key":"16429_CR25","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S1087-0792(98)90051-X","volume":"2","author":"C Gronfier","year":"1998","unstructured":"Gronfier, C. & Brandenberger, G. Ultradian rhythms in pituitary and adrenal hormones: their relations to sleep. Sleep Med Rev \n                           2, 17\u201329 (1998).","journal-title":"Sleep Med Rev"},{"key":"16429_CR26","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.mce.2011.06.042","volume":"349","author":"A Kalsbeek","year":"2012","unstructured":"Kalsbeek, A. et al. Circadian rhythms in the hypothalamo-pituitary-adrenal (HPA) axis. Mol Cell Endocrinol \n                           349, 20\u201329, https:\/\/doi.org\/10.1016\/j.mce.2011.06.042 (2012).","journal-title":"Mol Cell Endocrinol"},{"key":"16429_CR27","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1172\/JCI41192","volume":"120","author":"S Kiessling","year":"2010","unstructured":"Kiessling, S., Eichele, G. & Oster, H. Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag. J Clin Invest \n                           120, 2600\u20132609, https:\/\/doi.org\/10.1172\/JCI41192 (2010).","journal-title":"J Clin Invest"},{"key":"16429_CR28","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1002\/bies.201500026","volume":"37","author":"J Husse","year":"2015","unstructured":"Husse, J., Eichele, G. & Oster, H. Synchronization of the mammalian circadian timing system: Light can control peripheral clocks independently of the SCN clock: alternate routes of entrainment optimize the alignment of the body\u2019s circadian clock network with external time. Bioessays \n                           37, 1119\u20131128, https:\/\/doi.org\/10.1002\/bies.201500026 (2015).","journal-title":"Bioessays"},{"key":"16429_CR29","doi-asserted-by":"publisher","first-page":"e92959","DOI":"10.1371\/journal.pone.0092959","volume":"9","author":"S Kiessling","year":"2014","unstructured":"Kiessling, S., Sollars, P. J. & Pickard, G. E. Light stimulates the mouse adrenal through a retinohypothalamic pathway independent of an effect on the clock in the suprachiasmatic nucleus. PloS one \n                           9, e92959, https:\/\/doi.org\/10.1371\/journal.pone.0092959 (2014).","journal-title":"PloS one"},{"key":"16429_CR30","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.cmet.2005.09.009","volume":"2","author":"A Ishida","year":"2005","unstructured":"Ishida, A. et al. Light activates the adrenal gland: timing of gene expression and glucocorticoid release. Cell Metab \n                           2, 297\u2013307, https:\/\/doi.org\/10.1016\/j.cmet.2005.09.009 (2005).","journal-title":"Cell Metab"},{"key":"16429_CR31","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1177\/0748730405279866","volume":"20","author":"Y Fukuoka","year":"2005","unstructured":"Fukuoka, Y. et al. Glucocorticoid administration increases hPer1 mRNA levels in human peripheral blood mononuclear cells in vitro or in vivo. J Biol Rhythms \n                           20, 550\u2013553, https:\/\/doi.org\/10.1177\/0748730405279866 (2005).","journal-title":"J Biol Rhythms"},{"key":"16429_CR32","doi-asserted-by":"publisher","first-page":"e5650","DOI":"10.1371\/journal.pone.0005650","volume":"4","author":"C Cailotto","year":"2009","unstructured":"Cailotto, C. et al. Effects of nocturnal light on (clock) gene expression in peripheral organs: a role for the autonomic innervation of the liver. PloS one \n                           4, e5650, https:\/\/doi.org\/10.1371\/journal.pone.0005650 (2009).","journal-title":"PloS one"},{"key":"16429_CR33","doi-asserted-by":"crossref","first-page":"7326","DOI":"10.1523\/JNEUROSCI.22-17-07326.2002","volume":"22","author":"AB Reddy","year":"2002","unstructured":"Reddy, A. B., Field, M. D., Maywood, E. S. & Hastings, M. H. Differential resynchronisation of circadian clock gene expression within the suprachiasmatic nuclei of mice subjected to experimental jet lag. J Neurosci \n                           22, 7326\u20137330 (2002).","journal-title":"J Neurosci"},{"key":"16429_CR34","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1126\/science.1132430","volume":"314","author":"EL McDearmon","year":"2006","unstructured":"McDearmon, E. L. et al. Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice. Science \n                           314, 1304\u20131308, https:\/\/doi.org\/10.1126\/science.1132430 (2006).","journal-title":"Science"},{"key":"16429_CR35","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0092-8674(02)00825-5","volume":"110","author":"N Preitner","year":"2002","unstructured":"Preitner, N. et al. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell \n                           110, 251\u2013260 (2002).","journal-title":"Cell"},{"key":"16429_CR36","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.sleep.2015.06.011","volume":"16","author":"MZ Fang","year":"2015","unstructured":"Fang, M. Z. et al. Sleep interruption associated with house staff work schedules alters circadian gene expression. Sleep medicine \n                           16, 1388\u20131394, https:\/\/doi.org\/10.1016\/j.sleep.2015.06.011 (2015).","journal-title":"Sleep medicine"},{"key":"16429_CR37","doi-asserted-by":"publisher","unstructured":"Bracci, M. et al. Peripheral Skin Temperature and Circadian Biological Clock in Shift Nurses after a Day off. Int J Mol Sci \n                           17, https:\/\/doi.org\/10.3390\/ijms17050623 (2016).","DOI":"10.3390\/ijms17050623"},{"key":"16429_CR38","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1136\/oem.2009.053512","volume":"68","author":"RG Stevens","year":"2011","unstructured":"Stevens, R. G. et al. Considerations of circadian impact for defining \u2018shift work\u2019 in cancer studies: IARC Working Group Report. Occup Environ Med \n                           68, 154\u2013162, https:\/\/doi.org\/10.1136\/oem.2009.053512 (2011).","journal-title":"Occup Environ Med"},{"key":"16429_CR39","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1093\/ije\/dyp178","volume":"38","author":"RGLight-at-night Stevens","year":"2009","unstructured":"Stevens, R. G. Light-at-night circadian disruption and breast cancer: assessment of existing evidence. Int J Epidemiol \n                           38, 963\u2013970, https:\/\/doi.org\/10.1093\/ije\/dyp178 (2009).","journal-title":"Int J Epidemiol"},{"key":"16429_CR40","doi-asserted-by":"publisher","unstructured":"CCuesta, M., Boudreau, P., Cermakian, N. & Boivin, D. B. Skin temperature rhythms in humans respond to hanges in the timing of sleep and light Journal of Biological Rhythms \n                           32, 257\u2013273, https:\/\/doi:10.1177\/0748730417702974 (2017).","DOI":"10.1177\/0748730417702974"},{"key":"16429_CR41","doi-asserted-by":"publisher","first-page":"4143","DOI":"10.1182\/blood-2003-03-0779","volume":"102","author":"DB Boivin","year":"2003","unstructured":"Boivin, D. B. et al. Circadian clock genes oscillate in human peripheral blood mononuclear cells. Blood \n                           102, 4143\u20134145, https:\/\/doi.org\/10.1182\/blood-2003-03-0779 (2003).","journal-title":"Blood"},{"key":"16429_CR42","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3109\/07420528.2012.674592","volume":"29","author":"P Boudreau","year":"2012","unstructured":"Boudreau, P., Yeh, W. H., Dumont, G. A. & Boivin, D. B. A circadian rhythm in heart rate variability contributes to the increased cardiac sympathovagal response to awakening in the morning. Chronobiol Int \n                           29, 757\u2013768, https:\/\/doi.org\/10.3109\/07420528.2012.674592 (2012).","journal-title":"Chronobiol Int"},{"key":"16429_CR43","first-page":"E173","volume":"264","author":"P Linkowski","year":"1993","unstructured":"Linkowski, P. et al. Twin study of the 24-h cortisol profile: evidence for genetic control of the human circadian clock. Am J Physiol \n                           264, E173\u2013181 (1993).","journal-title":"Am J Physiol"},{"key":"16429_CR44","doi-asserted-by":"publisher","first-page":"e51929","DOI":"10.1371\/journal.pone.0051929","volume":"7","author":"A Shechter","year":"2012","unstructured":"Shechter, A., Lesperance, P., Ng Ying Kin, N. M. & Boivin, D. B. Pilot investigation of the circadian plasma melatonin rhythm across the menstrual cycle in a small group of women with premenstrual dysphoric disorder. PloS one \n                           7, e51929, https:\/\/doi.org\/10.1371\/journal.pone.0051929 (2012).","journal-title":"PloS one"},{"key":"16429_CR45","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1177\/074873049400900310","volume":"9","author":"ME Jewett","year":"1994","unstructured":"Jewett, M. E., Kronauer, R. E. & Czeisler, C. A. Phase-amplitude resetting of the human circadian pacemaker via bright light: a further analysis. J Biol Rhythms \n                           9, 295\u2013314 (1994).","journal-title":"J Biol Rhythms"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-16429-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-16429-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-16429-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T14:09:53Z","timestamp":1671804593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-16429-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,24]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["16429"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-16429-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,24]]},"assertion":[{"value":"15 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"D.B.B. reports doing conferences and consultation work on shift work related project.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"16310"}}