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Using a high-throughput bacterial 16S rRNA gene sequencing, we identified four community state types (CSTs). CST III (<jats:italic>Lactobacillusdominant<\/jats:italic>) and CST IV (IV-A, IV-B.1, IV-B.2; high-diversity) were found in 41% and 59% of samples, respectively. We did not find association of any CST to postpartum period (six or twelve months), HPV infection or cytology (normal or lesion). However, five bacterial genera were associated with cervical lesions (<jats:italic>Gardnerella, Aerococcus, Schlegelella, Moryella<\/jats:italic> and <jats:italic>Bifidobacterium<\/jats:italic>), with significant odds ratio (OR) of 40 (2.28\u2013706) for the presence of <jats:italic>Moryella<\/jats:italic> and 3.5 (1.36\u20138.9) for <jats:italic>Schlegelella<\/jats:italic>. Longitudinal analysis of samples at postpartum that regressed (lesion to normal), progressed (normal to lesion) and maintained the cytology (lesion or normal) evidenced <jats:italic>Gardnerella<\/jats:italic> with a significantly higher abundance in regressing lesions. In the current study, we report the first data on the cervical microbiota of HIV-positive women in the postpartum period. Consistent with previous studies of HIV-negative cohorts, HIV-positive women present a stable cervical microbiota of high-diversity in the postpartum period. Our results highlight that specific microbiota species may serve as sensors for changes in the cervical microenvironment associated with cervical lesions.<\/jats:p>","DOI":"10.1038\/s41598-017-17351-9","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T10:19:46Z","timestamp":1512555586000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Analysis of the cervical microbiome and potential biomarkers from postpartum HIV-positive women displaying cervical intraepithelial lesions"],"prefix":"10.1038","volume":"7","author":[{"given":"Gislaine","family":"Curty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7139-0865","authenticated-orcid":false,"given":"Raquel L.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana D.","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela I.","family":"Meyrelles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth S.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esmeralda A.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9013-2570","authenticated-orcid":false,"given":"Marcelo A.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"17351_CR1","unstructured":"Bruni, L. et al. 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