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KP1814 belongs to a novel sequence type (ST) assigned to ST2270. WGS identified four circular DNA sequences in KP1814, including two multidrug-resistance (MDR) plasmids, one virulence plasmid, and one circular form. The MDR plasmid pKP1814-1 (299.9 Kb) is untypeable, and carries two large mosaic multiresistance regions (MRRs). <jats:italic>bla<\/jats:italic><jats:sub>SFO-1<\/jats:sub> and <jats:italic>bla<\/jats:italic><jats:sub>IMP-4<\/jats:sub> co-exists on MRR1, and <jats:italic>bla<\/jats:italic><jats:sub>SFO-1<\/jats:sub> is associated with an IS\/Tn-independent genetic context. <jats:italic>bla<\/jats:italic><jats:sub>IMP-4<\/jats:sub> is carried by a novel In804-like integron (<jats:italic>intlI<\/jats:italic>-<jats:italic>bla<\/jats:italic><jats:sub>IMP-4<\/jats:sub>-<jats:italic>Kl.pn.I3<\/jats:italic>-<jats:italic>qacG2<\/jats:italic>-<jats:italic>aacA4<\/jats:italic>-<jats:italic>catB3<\/jats:italic>\u2206) associated with a novel Tn<jats:italic>1696<\/jats:italic>-like transposon (designed Tn<jats:italic>6404<\/jats:italic>) flanked by IS<jats:italic>5075<\/jats:italic>. The other MDR plasmid pKP1814-3 is a 95,701-bp IncFII plasmid, and is a hybrid of a <jats:italic>Shigella flexneri<\/jats:italic> plasmid pSF07201 and an <jats:italic>E<\/jats:italic>. <jats:italic>coli<\/jats:italic> plasmid pCA08. All resistance genes of pKP1814-3 were detected in a ~16-kb IS<jats:italic>26<\/jats:italic>-flanked composite transposon carried by a Tn<jats:italic>5396<\/jats:italic> transposon. The circular form (18.3 Kb) was composed of two parts belonging to pKP1814-1 and pKP1814-3, respectively. The plasmid pKP1814-2, carrying multiple virulence factors, encodes IncFIB<jats:sub>K<\/jats:sub> and IncFII<jats:sub>K<\/jats:sub> replicons with a size of 187,349\u2009bp. The coexistence of MDR and virulence plasmids largely enhances the bacterial fitness in the host and environment.<\/jats:p>","DOI":"10.1038\/s41598-017-17641-2","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T12:24:43Z","timestamp":1512476683000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A novel Tn1696-like composite transposon (Tn6404) harboring bla\n                     IMP-4 in a Klebsiella pneumoniae isolate carrying a rare ESBL gene bla\n                     SFO-1"],"prefix":"10.1038","volume":"7","author":[{"given":"Kai","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baohong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W. 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