{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:15:30Z","timestamp":1790248530151,"version":"4.1.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Male infertility is a major and growing problem and, in most cases, the specific root cause is unknown. Here we show that the transcription factor SOX30 plays a critical role in mouse spermatogenesis. <jats:italic>Sox30<\/jats:italic>-null mice are healthy and females are fertile, but males are sterile. In the absence of <jats:italic>Sox30<\/jats:italic> meiosis initiates normally in both sexes but, in males, germ cell development arrests during the post-meiotic round spermatid period. In the mutant testis, acrosome and axoneme development are aberrant, multinucleated germ cells (symplasts) form and round spermatids unable to process beyond step 3 of spermiogenesis. No elongated spermatids nor spermatozoa are produced. Thus, <jats:italic>Sox30<\/jats:italic> represents a rare example of a gene for which loss of function results in a complete arrest of spermatogenesis at the onset of spermiogenesis. Our results suggest that <jats:italic>SOX30<\/jats:italic> mutations may underlie some instances of unexplained non-obstructive azoospermia in humans.<\/jats:p>","DOI":"10.1038\/s41598-017-17854-5","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T09:56:59Z","timestamp":1512986219000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["SOX30 is required for male fertility in mice"],"prefix":"10.1038","volume":"7","author":[{"given":"Chun-Wei Allen","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassy","family":"Spiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna J.","family":"Merriner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7298-4940","authenticated-orcid":false,"given":"Moira K.","family":"O\u2019Bryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2867-7438","authenticated-orcid":false,"given":"Josephine","family":"Bowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Koopman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"17854_CR1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/aja.1000990303","volume":"99","author":"EF Oakberg","year":"1956","unstructured":"Oakberg, E. 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Asian journal of andrology \n                           13, 139\u2013151, https:\/\/doi.org\/10.1038\/aja.2010.101 (2011).","journal-title":"Asian journal of andrology"},{"key":"17854_CR6","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0092-8674(00)81834-6","volume":"88","author":"P Sassone-Corsi","year":"1997","unstructured":"Sassone-Corsi, P. Transcriptional checkpoints determining the fate of male germ cells. Cell \n                           88, 163\u2013166 (1997).","journal-title":"Cell"},{"key":"17854_CR7","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1210\/mend.7.11.8114765","volume":"7","author":"V Delmas","year":"1993","unstructured":"Delmas, V., van der Hoorn, F., Mellstrom, B., Jegou, B. & Sassone-Corsi, P. Induction of CREM activator proteins in spermatids: down-stream targets and implications for haploid germ cell differentiation. 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