{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:16:37Z","timestamp":1771002997839,"version":"3.50.1"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:00:00Z","timestamp":1516147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:00:00Z","timestamp":1516147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Results on the relationships between vitamin D receptor (VDR) gene polymorphisms and postmenopausal osteoporosis (PMOP) susceptibility and bone mineral density (BMD) are conflicting. The aim of the study is to identify more eligible studies that calculated pooled OR and WMD with 95% CI to assess their associations. Overall, there were significant correlations between VDR<jats:italic>Apa<\/jats:italic>I, VDR<jats:italic>Fok<\/jats:italic>I and PMOP susceptibility. Subgroup analysis showed that VDR<jats:italic>Apa<\/jats:italic>I polymorphism significantly decreased the osteoporosis risk in Caucasian postmenopausal women. In Asian populations, VDR<jats:italic>Bsm<\/jats:italic>I and VDR<jats:italic>Fok<\/jats:italic>I were associated with an increased risk of PMOP. As to the associations between VDR polymorphisms and BMD, Caucasian PMOP women carrying the<jats:italic>Apa<\/jats:italic>I aa genotype were at risk of high BMD in femoral neck, and low femoral neck BMD was observed in Caucasian PMOP women with<jats:italic>Fok<\/jats:italic>I Ff genotype. PMOP women with the<jats:italic>Cdx<\/jats:italic>2 GA genotype had a lower lumbar spine BMD in overall and Caucasian populations compared with PMOP women with GG genotype. Different VDR gene polymorphisms have different impacts on PMOP risk and BMD.<\/jats:p>","DOI":"10.1038\/s41598-017-18670-7","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T15:48:37Z","timestamp":1515685717000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["RETRACTED ARTICLE: Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A systematic review and Meta-Analysis"],"prefix":"10.1038","volume":"8","author":[{"given":"Liang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daolinag","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiandong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caifeng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,1,17]]},"reference":[{"key":"18670_CR1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.4103\/1735-1995.193503","volume":"21","author":"F Gokosmanoglu","year":"2016","unstructured":"Gokosmanoglu, F., Varim, C., Atmaca, A., Atmaca, M. H. & Colak, R. The effects of zoledronic acid treatment on depression and quality of life in women with postmenopausal osteoporosis: A clinical trial study. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences 21, 112, https:\/\/doi.org\/10.4103\/1735-1995.193503 (2016).","journal-title":"Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences"},{"key":"18670_CR2","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.ecl.2016.11.001","volume":"46","author":"L Bandeira","year":"2017","unstructured":"Bandeira, L. & Bilezikian, J. P. Novel Therapies for Postmenopausal Osteoporosis. Endocrinology and metabolism clinics of North America 46, 207\u2013219, https:\/\/doi.org\/10.1016\/j.ecl.2016.11.001 (2017).","journal-title":"Endocrinology and metabolism clinics of North America"},{"key":"18670_CR3","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1097\/gme.0b013e31825d24cf","volume":"20","author":"MA Martinez-Maestre","year":"2013","unstructured":"Martinez-Maestre, M. A. et al. Osteoporosis, fragility fracture, and periodontal disease: a cross-sectional study in Spanish postmenopausal women. Menopause (New York, N.Y.) 20, 79\u201384, https:\/\/doi.org\/10.1097\/gme.0b013e31825d24cf (2013).","journal-title":"Menopause (New York, N.Y.)"},{"key":"18670_CR4","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ejogrb.2016.01.037","volume":"199","author":"D Kotrych","year":"2016","unstructured":"Kotrych, D. et al. TNF-alpha and IL10 gene polymorphisms in women with postmenopausal osteoporosis. European journal of obstetrics, gynecology, and reproductive biology 199, 92\u201395, https:\/\/doi.org\/10.1016\/j.ejogrb.2016.01.037 (2016).","journal-title":"European journal of obstetrics, gynecology, and reproductive biology"},{"key":"18670_CR5","doi-asserted-by":"publisher","unstructured":"Shang, D. P. et al. Relationship between estrogen receptor 1 gene polymorphisms and postmenopausal osteoporosis of the spine in Chinese women. Genetics and molecular research: GMR 15, https:\/\/doi.org\/10.4238\/gmr.15028106 (2016).","DOI":"10.4238\/gmr.15028106"},{"key":"18670_CR6","doi-asserted-by":"publisher","first-page":"e461","DOI":"10.1097\/md.0000000000000461","volume":"94","author":"J Sun","year":"2015","unstructured":"Sun, J., Zhang, C., Xu, L., Yang, M. & Yang, H. The transforming growth factor-beta1 (TGF-beta1) gene polymorphisms (TGF-beta1 T869C and TGF-beta1 T29C) and susceptibility to postmenopausal osteoporosis: a meta-analysis. Medicine 94, e461, https:\/\/doi.org\/10.1097\/md.0000000000000461 (2015).","journal-title":"Medicine"},{"key":"18670_CR7","doi-asserted-by":"publisher","unstructured":"van Ballegooijen, A. J. et al. Association of Vitamin D Metabolites With Arterial Function in the Hemodialysis Fistula Maturation Study. American journal of kidney diseases: the official journal of the National Kidney Foundation, https:\/\/doi.org\/10.1053\/j.ajkd.2017.01.049(2017).","DOI":"10.1053\/j.ajkd.2017.01.049"},{"key":"18670_CR8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.5114\/aoms.2016.57475","volume":"12","author":"B Zhao","year":"2016","unstructured":"Zhao, B., Zhang, W., Du, S. & Zhou, Z. Vitamin D receptor BsmI polymorphism and osteoporosis risk in post-menopausal women. Archives of medical science: AMS 12, 25\u201330, https:\/\/doi.org\/10.5114\/aoms.2016.57475 (2016).","journal-title":"Archives of medical science: AMS"},{"key":"18670_CR9","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s11033-012-2086-x","volume":"40","author":"G Qin","year":"2013","unstructured":"Qin, G., Dong, Z., Zeng, P., Liu, M. & Liao, X. Association of vitamin D receptor BsmI gene polymorphism with risk of osteoporosis: a meta-analysis of 41 studies. Molecular biology reports 40, 497\u2013506, https:\/\/doi.org\/10.1007\/s11033-012-2086-x (2013).","journal-title":"Molecular biology reports"},{"key":"18670_CR10","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1902\/jop.2016.160222","volume":"87","author":"S Chantarangsu","year":"2016","unstructured":"Chantarangsu, S., Sura, T., Mongkornkarn, S., Donsakul, K. & Torrungruang, K. Vitamin D Receptor Gene Polymorphism and Smoking in the Risk of Chronic Periodontitis. Journal of periodontology 87, 1343\u20131351, https:\/\/doi.org\/10.1902\/jop.2016.160222 (2016).","journal-title":"Journal of periodontology"},{"key":"18670_CR11","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S0014-2565(00)70605-9","volume":"200","author":"R Fontova Garrofe","year":"2000","unstructured":"Fontova Garrofe, R. et al. Polymorphism of the gene for vitamin D receptor, bone mass, and bone turnover in women with postmenopausal osteoporosis. Revista clinica espanola 200, 198\u2013202 (2000).","journal-title":"Revista clinica espanola"},{"key":"18670_CR12","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1007\/s10067-010-1548-6","volume":"29","author":"M Durusu Tanriover","year":"2010","unstructured":"Durusu Tanriover, M. et al. Evaluation of the effects of vitamin D receptor and estrogen receptor 1 gene polymorphisms on bone mineral density in postmenopausal women. Clinical rheumatology 29, 1285\u20131293, https:\/\/doi.org\/10.1007\/s10067-010-1548-6 (2010).","journal-title":"Clinical rheumatology"},{"key":"18670_CR13","doi-asserted-by":"crossref","first-page":"501","DOI":"10.33549\/physiolres.930239","volume":"51","author":"K Zajickova","year":"2002","unstructured":"Zajickova, K., Zofkova, I., Bahbouh, R. & Krepelova, A. Vitamin D receptor gene polymorphisms, bone mineral density and bone turnover: FokI genotype is related to postmenopausal bone mass. Physiological research 51, 501\u2013509 (2002).","journal-title":"Physiological research"},{"key":"18670_CR14","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1353\/hub.2003.0045","volume":"75","author":"R Lisker","year":"2003","unstructured":"Lisker, R. et al. Association of vitamin D receptor polymorphisms with osteoporosis in mexican postmenopausal women. Human biology 75, 399\u2013403 (2003).","journal-title":"Human biology"},{"key":"18670_CR15","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1155\/2006\/921694","volume":"22","author":"E Zintzaras","year":"2006","unstructured":"Zintzaras, E., Rodopoulou, P. & Koukoulis, G. N. BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and the risk of osteoporosis: a meta-analysis. Disease markers 22, 317\u2013326 (2006).","journal-title":"Disease markers"},{"key":"18670_CR16","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1089\/gtmb.2012.0267","volume":"17","author":"F Jia","year":"2013","unstructured":"Jia, F. et al. Vitamin D receptor BsmI polymorphism and osteoporosis risk: a meta-analysis from 26 studies. Genetic testing and molecular biomarkers 17, 30\u201334, https:\/\/doi.org\/10.1089\/gtmb.2012.0267 (2013).","journal-title":"Genetic testing and molecular biomarkers"},{"key":"18670_CR17","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.cca.2010.11.035","volume":"412","author":"J Yasovanthi","year":"2011","unstructured":"Yasovanthi, J. et al. Association of vitamin D receptor gene polymorphisms with BMD and their effect on 1, 25-dihydroxy vitamin D3 levels in pre- and postmenopausal South Indian women from Andhra Pradesh. Clinica chimica acta; international journal of clinical chemistry 412, 541\u2013544, https:\/\/doi.org\/10.1016\/j.cca.2010.11.035 (2011).","journal-title":"Clinica chimica acta; international journal of clinical chemistry"},{"key":"18670_CR18","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1007\/s00198-014-2947-3","volume":"26","author":"D Boron","year":"2015","unstructured":"Boron, D. et al. Polymorphism of vitamin D3 receptor and its relation to mineral bone density in perimenopausal women. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 26, 1045\u20131052, https:\/\/doi.org\/10.1007\/s00198-014-2947-3 (2015).","journal-title":"Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"},{"key":"18670_CR19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s001980050213","volume":"10","author":"C Gomez","year":"1999","unstructured":"Gomez, C. et al. Vitamin D receptor gene polymorphisms, bone mass, bone loss and prevalence of vertebral fracture: differences in postmenopausal women and men. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 10, 175\u2013182, https:\/\/doi.org\/10.1007\/s001980050213 (1999).","journal-title":"Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"},{"key":"18670_CR20","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1046\/j.1365-2362.2000.00686.x","volume":"30","author":"BL Langdahl","year":"2000","unstructured":"Langdahl, B. L., Gravholt, C. H., Brixen, K. & Eriksen, E. F. Polymorphisms in the vitamin D receptor gene and bone mass, bone turnover and osteoporotic fractures. European journal of clinical investigation 30, 608\u2013617 (2000).","journal-title":"European journal of clinical investigation"},{"key":"18670_CR21","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s11033-012-2072-3","volume":"40","author":"W Horst-Sikorska","year":"2013","unstructured":"Horst-Sikorska, W. et al. Vitamin D receptor gene polymorphisms, bone mineral density and fractures in postmenopausal women with osteoporosis. Molecular biology reports 40, 383\u2013390, https:\/\/doi.org\/10.1007\/s11033-012-2072-3 (2013).","journal-title":"Molecular biology reports"},{"key":"18670_CR22","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1159\/000079524","volume":"13","author":"BS Duman","year":"2004","unstructured":"Duman, B. S., Tanakol, R., Erensoy, N., Ozturk, M. & Yilmazer, S. Vitamin D receptor alleles, bone mineral density and turnover in postmenopausal osteoporotic and healthy women. Medical principles and practice: international journal of the Kuwait University, Health Science Centre 13, 260\u2013266, https:\/\/doi.org\/10.1159\/000079524 (2004).","journal-title":"Medical principles and practice: international journal of the Kuwait University, Health Science Centre"},{"key":"18670_CR23","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s001980070079","volume":"11","author":"J Aerssens","year":"2000","unstructured":"Aerssens, J. et al. Polymorphisms of the VDR, ER and COLIA1 genes and osteoporotic hip fracture in elderly postmenopausal women. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 11, 583\u2013591, https:\/\/doi.org\/10.1007\/s001980070079 (2000).","journal-title":"Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"},{"key":"18670_CR24","first-page":"8173","volume":"8","author":"M Pedrera-Canal","year":"2015","unstructured":"Pedrera-Canal, M. et al. Common allelic variants of the vitamin receptor D geners7975232 (ApaI) do not influence bone mineral density figures in postmenopausal osteoporotic women. International journal of clinical and experimental medicine 8, 8173\u20138177 (2015).","journal-title":"International journal of clinical and experimental medicine"},{"key":"18670_CR25","first-page":"75","volume":"15","author":"F Pouresmaeili","year":"2013","unstructured":"Pouresmaeili, F., Jamshidi, J., Azargashb, E. & Samangouee, S. Association between Vitamin D Receptor Gene BsmI Polymorphism and Bone Mineral Density in A Population of 146 Iranian Women. Cell journal 15, 75\u201382 (2013).","journal-title":"Cell journal"},{"key":"18670_CR26","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1046\/j.1365-2265.2003.01724.x","volume":"58","author":"S Palomba","year":"2003","unstructured":"Palomba, S. et al. Effectiveness of alendronate treatment in postmenopausal women with osteoporosis: relationship with BsmI vitamin D receptor genotypes. Clinical endocrinology 58, 365\u2013371 (2003).","journal-title":"Clinical endocrinology"},{"key":"18670_CR27","first-page":"177","volume":"49","author":"P Marozik","year":"2013","unstructured":"Marozik, P. et al. Association Between Polymorphisms of VDR, COL1A1, and LCT genes and bone mineral density in Belarusian women with severe postmenopausal osteoporosis. Medicina (Kaunas, Lithuania) 49, 177\u2013184 (2013).","journal-title":"Medicina (Kaunas, Lithuania)"},{"key":"18670_CR28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.15407\/fz61.05.021","volume":"61","author":"DS Ziablitsev","year":"2015","unstructured":"Ziablitsev, D. S. & Larin, O. S. Influence of single nucleotide polymorphisms of vitamin D receptor-gene on the level of osteoassociated hormones linkage with postmenopausal osteoporosis. Fiziolohichnyi zhurnal (Kiev, Ukraine: 1994) 61, 21\u201327 (2015).","journal-title":"Fiziolohichnyi zhurnal (Kiev, Ukraine: 1994)"},{"key":"18670_CR29","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1359\/jbmr.1999.14.8.1379","volume":"14","author":"L Gennari","year":"1999","unstructured":"Gennari, L. et al. FokI polymorphism at translation initiation site of the vitamin D receptor gene predicts bone mineral density and vertebral fractures in postmenopausal Italian women. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 14, 1379\u20131386, https:\/\/doi.org\/10.1359\/jbmr.1999.14.8.1379 (1999).","journal-title":"Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research"},{"key":"18670_CR30","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.mefs.2010.05.002","volume":"15","author":"L Mansour","year":"2010","unstructured":"Mansour, L. et al. The role of vitamin D receptor genes (FOKI and BSMI) polymorphism in osteoporosis. Middle East Fertility Society Journal 15, 79\u201383 (2010).","journal-title":"Middle East Fertility Society Journal"},{"key":"18670_CR31","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3109\/13697137.2015.1007123","volume":"18","author":"R Sassi","year":"2015","unstructured":"Sassi, R., Sahli, H., Souissi, C. & Sellami, S. & Ben Ammar El Gaaied, A. Polymorphisms in VDR gene in Tunisian postmenopausal women are associated with osteopenia phenotype. Climacteric: the journal of the International Menopause. Society 18, 624\u2013630, https:\/\/doi.org\/10.3109\/13697137.2015.1007123 (2015).","journal-title":"Society"},{"key":"18670_CR32","first-page":"472","volume":"151","author":"OD Castelan-Martinez","year":"2015","unstructured":"Castelan-Martinez, O. D., Vivanco-Munoz, N., Falcon-Ramirez, E., Valdes-Flores, M. & Clark, P. Apa1 VDR polymorphism and osteoporosis risk in postmenopausal Mexican women. Gaceta medica de Mexico 151, 472\u2013476 (2015).","journal-title":"Gaceta medica de Mexico"},{"key":"18670_CR33","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.4238\/2013.July.30.13","volume":"12","author":"A Gonzalez-Mercado","year":"2013","unstructured":"Gonzalez-Mercado, A. et al. Association analysis of vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Mexican-Mestizo women. Genetics and molecular research: GMR 12, 2755\u20132763, https:\/\/doi.org\/10.4238\/2013.July.30.13 (2013).","journal-title":"Genetics and molecular research: GMR"},{"key":"18670_CR34","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3109\/13697137.2010.550973","volume":"14","author":"T Yoldemir","year":"2011","unstructured":"Yoldemir, T., Yavuz, D. G., Anik, G., Verimli, N. & Erenus, M. Vitamin D receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density. Climacteric: the journal of the International Menopause. Society 14, 384\u2013391, https:\/\/doi.org\/10.3109\/13697137.2010.550973 (2011).","journal-title":"Society"},{"key":"18670_CR35","first-page":"9486","volume":"15","author":"J Luan","year":"2011","unstructured":"Luan, J., Fan, X. & Chen, Z. The associations between VDR gene polymorphisms and osteoporosis. Zhong guo zu zhi gong cheng yan jiu. 15, 9486\u20139490 (2011).","journal-title":"Zhong guo zu zhi gong cheng yan jiu."},{"key":"18670_CR36","first-page":"540","volume":"30","author":"A Seremak-Mrozikiewicz","year":"2009","unstructured":"Seremak-Mrozikiewicz, A. et al. Correlation of vitamin D receptor gene (VDR) polymorphism with osteoporotic changes in Polish postmenopausal women. Neuro endocrinology letters 30, 540\u2013546 (2009).","journal-title":"Neuro endocrinology letters"},{"key":"18670_CR37","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1089\/gte.2008.0052","volume":"12","author":"AR Uysal","year":"2008","unstructured":"Uysal, A. R., Sahin, M., Gursoy, A. & Gullu, S. Vitamin D receptor gene polymorphism and osteoporosis in the Turkish population. Genetic testing 12, 591\u2013594, https:\/\/doi.org\/10.1089\/gte.2008.0052 (2008).","journal-title":"Genetic testing"},{"key":"18670_CR38","first-page":"402","volume":"13","author":"Z Chen","year":"2007","unstructured":"Chen, Z. et al. The study of the association between Apa I polymorphism of vitamin D receptor gene and osteoporosis. Chinese Journal of Osteoporosis 13, 402\u2013405 (2007).","journal-title":"Chinese Journal of Osteoporosis"},{"key":"18670_CR39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.maturitas.2006.01.003","volume":"55","author":"S Mitra","year":"2006","unstructured":"Mitra, S., Desai, M. & Ikram Khatkhatay, M. Vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Indian women. Maturitas 55, 27\u201335, https:\/\/doi.org\/10.1016\/j.maturitas.2006.01.003 (2006).","journal-title":"Maturitas"},{"key":"18670_CR40","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0378-5122(03)00148-8","volume":"45","author":"K Douroudis","year":"2003","unstructured":"Douroudis, K. et al. Association of vitamin D receptor gene polymorphisms with bone mineral density in postmenopausal women of Hellenic origin. Maturitas 45, 191\u2013197 (2003).","journal-title":"Maturitas"},{"key":"18670_CR41","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1210\/jcem.83.3.4649","volume":"83","author":"L Gennari","year":"1998","unstructured":"Gennari, L. et al. Vitamin D and estrogen receptor allelic variants in Italian postmenopausal women: evidence of multiple gene contribution to bone mineral density. The Journal of clinical endocrinology and metabolism 83, 939\u2013944, https:\/\/doi.org\/10.1210\/jcem.83.3.4649 (1998).","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"18670_CR42","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1359\/jbmr.1997.12.2.241","volume":"12","author":"C Vandevyver","year":"1997","unstructured":"Vandevyver, C., Wylin, T., Cassiman, J. J., Raus, J. & Geusens, P. Influence of the vitamin D receptor gene alleles on bone mineral density in postmenopausal and osteoporotic women. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 12, 241\u2013247, https:\/\/doi.org\/10.1359\/jbmr.1997.12.2.241 (1997).","journal-title":"Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research"},{"key":"18670_CR43","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1002\/jbmr.5650100622","volume":"10","author":"BL Riggs","year":"1995","unstructured":"Riggs, B. L. et al. The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 10, 991\u2013996, https:\/\/doi.org\/10.1002\/jbmr.5650100622 (1995).","journal-title":"Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research"},{"key":"18670_CR44","first-page":"295","volume":"26","author":"A Efesoy","year":"2011","unstructured":"Efesoy, A. et al. Relationship of the vitamin D receptor and collagen I [alpha] 1 gene polymorphisms with low bone mineral density and vertebral fractures in postmenopausal Turkish women\/postmenopozal Turk kadinlarinda D vitamini reseptoru geni ve kollajen I [alpha] 1 geni polimorfizmlerinin dusuk kemik mineral yogunlugu ve vertebral kiriklar ile iliskisi. Turkish. Journal of Rheumatology 26, 295\u2013303 (2011).","journal-title":"Journal of Rheumatology"},{"key":"18670_CR45","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s00774-009-0041-2","volume":"27","author":"M Musumeci","year":"2009","unstructured":"Musumeci, M. et al. Genetic and environmental factors in human osteoporosis from Sub-Saharan to Mediterranean areas. Journal of bone and mineral metabolism 27, 424\u2013434, https:\/\/doi.org\/10.1007\/s00774-009-0041-2 (2009).","journal-title":"Journal of bone and mineral metabolism"},{"key":"18670_CR46","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1677\/jme-08-0108","volume":"42","author":"S Mencej-Bedrac","year":"2009","unstructured":"Mencej-Bedrac, S. et al. The combinations of polymorphisms in vitamin D receptor, osteoprotegerin and tumour necrosis factor superfamily member 11 genes are associated with bone mineral density. Journal of molecular endocrinology 42, 239\u2013247, https:\/\/doi.org\/10.1677\/jme-08-0108 (2009).","journal-title":"Journal of molecular endocrinology"},{"key":"18670_CR47","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/s00774-007-0840-2","volume":"26","author":"A Perez","year":"2008","unstructured":"Perez, A. et al. Genotypes and clinical aspects associated with bone mineral density in Argentine postmenopausal women. Journal of bone and mineral metabolism 26, 358\u2013365, https:\/\/doi.org\/10.1007\/s00774-007-0840-2 (2008).","journal-title":"Journal of bone and mineral metabolism"},{"key":"18670_CR48","first-page":"140","volume":"10","author":"Minjia Zhu","year":"2004","unstructured":"Zhu, Minjia, Yan, Xiaodong, Wang, Feng, Chen, Youhua & Huang, Zhong The relationship between VDR gene polymorphism and BMD in postmenopausal women in Zhuang and Han populations in Guangxi Area. Chinese Journal of Osteoporosis 10, 140\u2013142 (2004).","journal-title":"Chinese Journal of Osteoporosis"},{"key":"18670_CR49","first-page":"167","volume":"20","author":"Jun Chen","year":"2003","unstructured":"Chen, Jun, Zhang, Liping & Qiu, Junfeng et al. The relationship between VDR gene polymorphism and PMOP in Chongqin Area. Chinese. Journal of Medical Genetics 20, 167\u2013168 (2003).","journal-title":"Journal of Medical Genetics"},{"key":"18670_CR50","first-page":"275","volume":"44","author":"L Borjas-Fajardo","year":"2003","unstructured":"Borjas-Fajardo, L. et al. [Analysis of Bsm I polymorphism of the vitamin D receptor (VDR) gene in Venezuelan female patients living in the state of Zulia with osteoporosis]. Investigacion clinica 44, 275\u2013282 (2003).","journal-title":"Investigacion clinica"},{"key":"18670_CR51","doi-asserted-by":"crossref","unstructured":"Pollak, R. D., Blumenfeld, A., Bejarano-Achache, I., Idelson, M. & Celinke Hochner, D. The BsmI vitamin D receptor gene polymorphism in Israeli populations and in perimenopausal and osteoporotic Ashkenazi women. American journal of nephrology 21, 185\u2013188, doi:46245 (2001).","DOI":"10.1159\/000046245"},{"key":"18670_CR52","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1155\/1999\/935791","volume":"15","author":"M Poggi","year":"1999","unstructured":"Poggi, M. et al. Lack of association between body weight, bone mineral density and vitamin D receptor gene polymorphism in normal and osteoporotic women. Disease markers 15, 221\u2013227 (1999).","journal-title":"Disease markers"},{"key":"18670_CR53","first-page":"12","volume":"19","author":"Honghong Zhang","year":"1998","unstructured":"Zhang, Honghong & Tao, Guoshu et al. Preliminary Studies on the RelaUonship between Vitamin D Receptor Genepolymorphtsm and Osteoporosis in Chinese Wome. Chinese. Journal of Epidemiology 19, 12\u201314 (1998).","journal-title":"Journal of Epidemiology"},{"key":"18670_CR54","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/8756-3282(95)00483-1","volume":"18","author":"LA Houston","year":"1996","unstructured":"Houston, L. A., Grant, S. F., Reid, D. M. & Ralston, S. H. Vitamin D receptor polymorphism, bone mineral density, and osteoporotic vertebral fracture: studies in a UK population. Bone 18, 249\u2013252 (1996).","journal-title":"Bone"},{"key":"18670_CR55","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1530\/eje.0.1350096","volume":"135","author":"JP Berg","year":"1996","unstructured":"Berg, J. P., Falch, J. A. & Haug, E. Fracture rate, pre- and postmenopausal bone mass and early and late postmenopausal bone loss are not associated with vitamin D receptor genotype in a high-endemic area of osteoporosis. European journal of endocrinology 135, 96\u2013100 (1996).","journal-title":"European journal of endocrinology"},{"key":"18670_CR56","doi-asserted-by":"publisher","first-page":"4179","DOI":"10.1210\/jcem.81.11.8923886","volume":"81","author":"H Yanagi","year":"1996","unstructured":"Yanagi, H. et al. Vitamin D receptor gene polymorphisms are associated with osteoporosis in Japanese women. The Journal of clinical endocrinology and metabolism 81, 4179\u20134181, https:\/\/doi.org\/10.1210\/jcem.81.11.8923886 (1996).","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"18670_CR57","doi-asserted-by":"publisher","first-page":"3677","DOI":"10.1210\/jcem.80.12.8530619","volume":"80","author":"SK Lim","year":"1995","unstructured":"Lim, S. K. et al. Lack of association between vitamin D receptor genotypes and osteoporosis in Koreans. The Journal of clinical endocrinology and metabolism 80, 3677\u20133681, https:\/\/doi.org\/10.1210\/jcem.80.12.8530619 (1995).","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"18670_CR58","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S0140-6736(94)92297-7","volume":"344","author":"H Melhus","year":"1994","unstructured":"Melhus, H. et al. Vitamin D receptor genotypes in osteoporosis. Lancet (London, England) 344, 949\u2013950 (1994).","journal-title":"Lancet (London, England)"},{"key":"18670_CR59","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1006\/bbrc.1998.8880","volume":"248","author":"L Masi","year":"1998","unstructured":"Masi, L. et al. Polymorphisms of the calcitonin receptor gene are associated with bone mineral density in postmenopausal Italian women. Biochemical and biophysical research communications 248, 190\u2013195, https:\/\/doi.org\/10.1006\/bbrc.1998.8880 (1998).","journal-title":"Biochemical and biophysical research communications"},{"key":"18670_CR60","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1007\/s100380070016","volume":"45","author":"YM Choi","year":"2000","unstructured":"Choi, Y. M. et al. Association of the vitamin D receptor start codon polymorphism (FokI) with bone mineral density in postmenopausal Korean women. Journal of human genetics 45, 280\u2013283, https:\/\/doi.org\/10.1007\/s100380070016 (2000).","journal-title":"Journal of human genetics"},{"key":"18670_CR61","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1034\/j.1399-0004.1999.560307.x","volume":"56","author":"G Lucotte","year":"1999","unstructured":"Lucotte, G., Mercier, G. & Burckel, A. The vitamin D receptor FokI start codon polymorphism and bone mineral density in osteoporotic postmenopausal French women. Clinical genetics 56, 221\u2013224 (1999).","journal-title":"Clinical genetics"},{"key":"18670_CR62","first-page":"238","volume":"29","author":"Z Mohammadi","year":"2015","unstructured":"Mohammadi, Z. et al. Prevalence of osteoporosis and vitamin D receptor gene polymorphisms (FokI) in an Iranian general population based study (Kurdistan) (IMOS). Medical journal of the Islamic Republic of Iran 29, 238 (2015).","journal-title":"Medical journal of the Islamic Republic of Iran"},{"key":"18670_CR63","first-page":"42","volume":"10","author":"Jirong Ge","year":"2006","unstructured":"Ge, Jirong, Li, Shengqiong, Zhu, Xiaoxiang & Chen, Ke Bsm I polyraorphism of vitamin D receptor gene and traditional Chinese medicine diffrentiation type in relation to bone mineral density in female patients with postmenopausal osteoporosis. Chinese. Journal Clinical Rehabilitation 10, 42\u201344 (2006).","journal-title":"Journal Clinical Rehabilitation"},{"key":"18670_CR64","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s00198-004-1800-5","volume":"16","author":"S Palomba","year":"2005","unstructured":"Palomba, S. et al. BsmI vitamin D receptor genotypes influence the efficacy of antiresorptive treatments in postmenopausal osteoporotic women. A 1-year multicenter, randomized and controlled trial. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 16, 943\u2013952, https:\/\/doi.org\/10.1007\/s00198-004-1800-5 (2005).","journal-title":"Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"},{"key":"18670_CR65","doi-asserted-by":"publisher","first-page":"4829","DOI":"10.1210\/jc.2005-0364","volume":"90","author":"P Garnero","year":"2005","unstructured":"Garnero, P., Munoz, F., Borel, O., Sornay-Rendu, E. & Delmas, P. D. Vitamin D receptor gene polymorphisms are associated with the risk of fractures in postmenopausal women, independently of bone mineral density. The Journal of clinical endocrinology and metabolism 90, 4829\u20134835, https:\/\/doi.org\/10.1210\/jc.2005-0364 (2005).","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"18670_CR66","first-page":"563","volume":"23","author":"WU Wen","year":"2007","unstructured":"Wen, W. U., Ximei, Z. H. I., Dongfeng, L. I., Kai, L. I. N. & Ling, X. U. YANG Yanhong. Relationship between bone mineral density and polymorphism of vitamin D receptor gene in postmenopausal women in Guangzhou. Chinese. Journal of Pathophysiology. 23, 563\u2013565 (2007).","journal-title":"Journal of Pathophysiology."},{"key":"18670_CR67","doi-asserted-by":"publisher","first-page":"e953","DOI":"10.7717\/peerj.953","volume":"3","author":"JM Moran","year":"2015","unstructured":"Moran, J. M. et al. Lack of association of vitamin D receptor BsmI gene polymorphism with bone mineral density in Spanish postmenopausal women. PeerJ 3, e953, https:\/\/doi.org\/10.7717\/peerj.953 (2015).","journal-title":"PeerJ"},{"key":"18670_CR68","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1111\/j.1447-0756.2011.01557.x","volume":"37","author":"M Creatsa","year":"2011","unstructured":"Creatsa, M. et al. The effect of vitamin D receptor BsmI genotype on the response to osteoporosis treatment in postmenopausal women: a pilot study. The journal of obstetrics and gynaecology research 37, 1415\u20131422, https:\/\/doi.org\/10.1111\/j.1447-0756.2011.01557.x (2011).","journal-title":"The journal of obstetrics and gynaecology research"},{"key":"18670_CR69","first-page":"397","volume":"23","author":"HeJinwei Zhang Zhenlin","year":"2006","unstructured":"Zhang Zhenlin, He. Jinwei et al. Relationship between the polymorphism of start codon and CDX2 site in vitamin D receptor gene and the effect of calcium supplentation on bone nineral density of postmenopausal women. Chinese Journal of Medical Genetics 23, 397\u2013401 (2006).","journal-title":"Chinese Journal of Medical Genetics"},{"key":"18670_CR70","first-page":"3","volume":"26","author":"Xu Xing Shaoji","year":"2010","unstructured":"Xing Shaoji, Xu & Xiuju, ZhangLifang et al. Association of Fork I Polymorphisms in vitamin D Receptor Gene with Bone Mineral Density in Postmenopausal Women of the Han Nationality in Inner Mongolian Area of China. Journal of Baotou Medical College 26, 3\u20135 (2010).","journal-title":"Journal of Baotou Medical College"},{"key":"18670_CR71","doi-asserted-by":"publisher","first-page":"e0138606","DOI":"10.1371\/journal.pone.0138606","volume":"10","author":"M Pedrera-Canal","year":"2015","unstructured":"Pedrera-Canal, M. et al. Lack of Influence of Vitamin D Receptor BsmI (rs1544410) Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Spanish Women Affected by Osteoporosis and Followed for Five Years. PloS one 10, e0138606, https:\/\/doi.org\/10.1371\/journal.pone.0138606 (2015).","journal-title":"PloS one"},{"key":"18670_CR72","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3109\/13697137.2013.856401","volume":"17","author":"H Shen","year":"2014","unstructured":"Shen, H., Xie, J. & Lu, H. Vitamin D receptor gene and risk of fracture in postmenopausal women: a meta-analysis. Climacteric: the journal of the International Menopause. Society 17, 319\u2013324, https:\/\/doi.org\/10.3109\/13697137.2013.856401 (2014).","journal-title":"Society"},{"key":"18670_CR73","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.bone.2006.04.016","volume":"39","author":"Y Fang","year":"2006","unstructured":"Fang, Y. et al. Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: a meta-analysis. Bone 39, 938\u2013945, https:\/\/doi.org\/10.1016\/j.bone.2006.04.016 (2006).","journal-title":"Bone"},{"key":"18670_CR74","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.humimm.2015.04.002","volume":"76","author":"VS Neela","year":"2015","unstructured":"Neela, V. S. et al. Association of Taq I, Fok I and Apa I polymorphisms in Vitamin D Receptor (VDR) gene with leprosy. Human immunology 76, 402\u2013405, https:\/\/doi.org\/10.1016\/j.humimm.2015.04.002 (2015).","journal-title":"Human immunology"},{"key":"18670_CR75","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.ejogrb.2013.03.031","volume":"169","author":"D Wang","year":"2013","unstructured":"Wang, D. et al. Vitamin D receptor Fok I polymorphism is associated with low bone mineral density in postmenopausal women: a meta-analysis focused on populations in Asian countries. European journal of obstetrics, gynecology, and reproductive biology 169, 380\u2013386, https:\/\/doi.org\/10.1016\/j.ejogrb.2013.03.031 (2013).","journal-title":"European journal of obstetrics, gynecology, and reproductive biology"},{"key":"18670_CR76","first-page":"90","volume":"18","author":"Z Zhang","year":"2002","unstructured":"Zhang, Z., Meng, X. & Zhou, X. Association of vitamin D receptor gene and calcitonin receptor gene polymorphisms with bone mineral density in women of the Han nationality in Beijing area. Zhonghua Nei Fen Mi Dai Xie Za Zhi 18, 90\u201394 (2002).","journal-title":"Zhonghua Nei Fen Mi Dai Xie Za Zhi"}],"updated-by":[{"DOI":"10.1038\/s41598-021-88654-1","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"record-id":"27760"},{"DOI":"10.1038\/s41598-021-88654-1","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-18670-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-18670-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-18670-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T12:37:46Z","timestamp":1719751066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-017-18670-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,17]]},"references-count":76,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["18670"],"URL":"https:\/\/doi.org\/10.1038\/s41598-017-18670-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,17]]},"assertion":[{"value":"25 April 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-021-88654-1","URL":"https:\/\/doi.org\/10.1038\/s41598-021-88654-1","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"981"}}