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In the current study, as a first attempt, we examined the hypothesis that visual inputs during high-speed driving would activate the mesolimbic dopaminergic system that plays an important role in mediating motivational craving. To this end, we used functional magnetic resonance imaging to identify speed-related activation changes in mesolimbic dopaminergic regions during the observation of driver-view videos in two groups that differed in self-reported speeding propensity. Results revealed, as we expected, greater activation in the ventral tegmental area (VTA) in response to driver-view videos with higher speed. Contrary to our expectation, however, we found no significant between-group difference in speed-related activation changes in mesolimbic dopaminergic regions. Instead, an exploratory psychophysiological interaction analysis found that self-reported speeding propensity was associated with speed-related functional coupling between the VTA and the right intraparietal sulcus. Further validation of our hypothesis will require future studies examining associations between speed-related activation in the mesolimbic dopaminergic system and individual differences in speeding propensity, using a more reliable measure of actual speeding propensity in real traffic.<\/jats:p>","DOI":"10.1038\/s41598-017-18792-y","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T10:04:06Z","timestamp":1515492246000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Speed-related activation in the mesolimbic dopamine system during the observation of driver-view videos"],"prefix":"10.1038","volume":"8","author":[{"given":"Hiroyuki","family":"Sakai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiro","family":"Sadato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1581-8668","authenticated-orcid":false,"given":"Yuji","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,1,15]]},"reference":[{"key":"18792_CR1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1080\/17450100903435037","volume":"5","author":"O Hagman","year":"2010","unstructured":"Hagman, O. 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