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Generalized additive models were used to analyze the effect of air pollutants on mortalities or outpatient visits. The average concentrations of air pollutants in Hangzhou (HZ) were 1.6\u20132.8 times higher than those in Zhoushan (ZS), except for O<jats:sub>3<\/jats:sub>. In a single pollutant model, the increased concentrations of PM<jats:sub>2.5<\/jats:sub>, NO<jats:sub>2<\/jats:sub>, and SO<jats:sub>2<\/jats:sub> were strongly associated with deaths caused by RD in HZ, while PM<jats:sub>2.5<\/jats:sub> and O<jats:sub>3<\/jats:sub> were associated with deaths caused by RD in ZS. All air pollutants (PM<jats:sub>2.5<\/jats:sub>, NO<jats:sub>2<\/jats:sub>, SO<jats:sub>2<\/jats:sub>, and O<jats:sub>3<\/jats:sub>) were strongly associated with outpatient visits for RD in both HZ and ZS. In multiple pollutant models, a significant association was only observed between PM<jats:sub>2.5<\/jats:sub> and the mortality rate of RD patients in both HZ and in ZS. Moreover, strong associations between SO<jats:sub>2<\/jats:sub>, NO<jats:sub>2<\/jats:sub>, and outpatient visits for RD were observed in HZ and ZS. This study has provided evidence that both the mortality rates and outpatient visits for RD were significantly associated with air pollutants. Furthermore, the results showed that different air pollutant levels lead to regional differences between mortality rates and outpatient visits.<\/jats:p>","DOI":"10.1038\/s41598-018-19939-1","type":"journal-article","created":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T10:43:00Z","timestamp":1518777780000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Acute effects of air pollution on respiratory disease mortalities and outpatients in Southeastern China"],"prefix":"10.1038","volume":"8","author":[{"given":"Zhe","family":"Mo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuli","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"19939_CR1","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1016\/S0140-6736(13)62693-8","volume":"382","author":"P Xu","year":"2013","unstructured":"Xu, P., Chen, Y. & Ye, X. 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