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We investigated the effect of the individual neural transfer function (iNTF) on the quality of the prediction of the subjective DoF from objective wavefront measures. Subjective DoF was assessed in 22 participants using subjective through focus curves of visual acuity (VA). Objective defocus curves were calculated for visual Strehl metrics of the optical (VSOTFa) and the modulation transfer function as well as the point spread function. DoF was computed for residual lower order aberrations (rLoA) and incorporation of iNTF. Correlations between subjective and objective DoF did not reach significance, when a) standard metrics were used and b) rLoA were considered (r<jats:sub>\n                  <jats:italic>max<\/jats:italic>\n                <\/jats:sub>\u2009=\u20090.33, p<jats:sub>\n                  <jats:italic>all<\/jats:italic>\n                <\/jats:sub>\u2009&gt;\u20090.05). By incorporating the iNTF of the individuals in the calculation of the objective DoF from the VSOTFa metric, a moderate statistically significant correlation was found (r\u2009=\u20090.43, p\u2009&lt;\u20090.01, Pearson). The iNTF of the individual\u2019s eye is fundamental for the prediction of subjective DoF using the VSOTFa metric. Individualized predictions could aid future application in the correction of refractive errors like presbyopia using intraocular lenses.<\/jats:p>","DOI":"10.1038\/s41598-018-20344-x","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T16:51:59Z","timestamp":1516812719000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Individual neural transfer function affects the prediction of subjective depth of focus"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9182-5408","authenticated-orcid":false,"given":"Alexander","family":"Leube","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Ohlendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex G.","family":"Ochakovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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GmbH. The work was supported by third-party-funding (ZUK 63)\u00a0as part of the German Excellence initiative from the Federal Ministry of Education and Research (BMBF). A. Ohlendorf and S. Wahl are employees of Carl Zeiss. Vision International GmbH. A.Leube, D. Kern, A. Ochakovski and D. Fischer declare no potential conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"1919"}}