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Non-coding RNAs are crucially involved in its pathophysiology. We identified hypoxia-induced long non-coding RNA <jats:italic>Malat1<\/jats:italic> (Metastasis Associated Lung Adenocarcinoma Transcript 1) to be upregulated in renal I\/R injury. We here elucidated the functional role of <jats:italic>Malat1 in vitro<\/jats:italic> and its potential contribution to kidney injury <jats:italic>in vivo<\/jats:italic>. <jats:italic>Malat1<\/jats:italic> was upregulated in kidney biopsies and plasma of patients with AKI, in murine hypoxic kidney tissue as well as in cultured and <jats:italic>ex vivo<\/jats:italic> sorted hypoxic endothelial cells and tubular epithelial cells. <jats:italic>Malat1<\/jats:italic> was transcriptionally activated by hypoxia-inducible factor 1-\u03b1. <jats:italic>In vitro<\/jats:italic>, <jats:italic>Malat1<\/jats:italic> inhibition reduced proliferation and the number of endothelial cells in the S-phase of the cell cycle. <jats:italic>In vivo<\/jats:italic>, <jats:italic>Malat1<\/jats:italic> knockout and wildtype mice showed similar degrees of outer medullary tubular epithelial injury, proliferation, capillary rarefaction, inflammation and fibrosis, survival and kidney function. Small-RNA sequencing and whole genome expression analysis revealed only minor changes between ischemic <jats:italic>Malat1<\/jats:italic> knockout and wildtype mice. Contrary to previous studies, which suggested a prominent role of <jats:italic>Malat1<\/jats:italic> in the induction of disease, we did not confirm an <jats:italic>in vivo<\/jats:italic> role of <jats:italic>Malat1<\/jats:italic> concerning renal I\/R-injury.<\/jats:p>","DOI":"10.1038\/s41598-018-21720-3","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T17:07:57Z","timestamp":1518714477000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Hypoxia-induced long non-coding RNA Malat1 is dispensable for renal ischemia\/reperfusion-injury"],"prefix":"10.1038","volume":"8","author":[{"given":"Malte","family":"K\u00f6lling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina","family":"Genschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Kaucsar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"H\u00fcbner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"S\u00f6rensen-Zender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kistler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Seeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan T.","family":"Kielstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Fliser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Haller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"W\u00fcthrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Z\u00f6rnig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Thum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Lorenzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"21720_CR1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.semnephrol.2005.09.003","volume":"26","author":"KJ Kelly","year":"2006","unstructured":"Kelly, K. 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