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However, exogenous H<jats:sub>2<\/jats:sub>S in combination with 17.5% oxygen is able to induce hypoxia, which in itself is a trigger of hypometabolism\/hypothermia. Using non-invasive thermographic imaging, we demonstrated that mice exposed to hypoxia (5% oxygen) reduce their body temperature to ambient temperature. In contrast, animals exposed to 80 ppm H<jats:sub>2<\/jats:sub>S under normoxic conditions did not exhibit a reduction in body temperature compared to normoxic controls. In conclusion, mice induce hypothermia in response to hypoxia but not H<jats:sub>2<\/jats:sub>S gas, which contradicts the reported findings and putative contentions.<\/jats:p>","DOI":"10.1038\/s41598-018-21729-8","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T11:05:20Z","timestamp":1519383920000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Exogenous hydrogen sulfide gas does not induce hypothermia in normoxic mice"],"prefix":"10.1038","volume":"8","author":[{"given":"Sebastiaan D.","family":"Hemelrijk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel C.","family":"Dirkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit H. 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