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We examined the prevalence of metabolic syndrome in relation to <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection and its symptoms in a large and unselected population. Coded data from the computerised database of a large health maintenance organisation in Israel were accessed for 147,936 individuals 25\u201395 years of age who performed the urea breath test during 2002\u20132012. The classification of metabolic syndrome followed a modified definition of the international diabetes federation. Prevalences of <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection and metabolic syndrome were 52.0% and 11.4% respectively. <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infected patients had increased likelihood of metabolic syndrome: adjusted odds ratio (aOR) 1.15 (95% confidence intervals (CI) 1.10\u20131.19), as did patients with gastric ulcer: aOR 1.15 (95% CI 1.03\u20131.28) vs patients without these conditions. Duodenal ulcer was associated with metabolic syndrome only in persons aged 25\u201334 years: aOR 1.59 (95% CI 1.19-2.13), but not in older persons (P\u2009=\u20090.001 for heterogeneity). In conclusion, the likelihood of metabolic syndrome appeared significantly increased in relation to <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection and gastric and duodenal ulcers. These findings suggest that <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> long-term gastric inflammation might play a role in metabolic homeostasis.<\/jats:p>","DOI":"10.1038\/s41598-018-22198-9","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T12:32:16Z","timestamp":1519821136000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Relationships of H. pylori infection and its related gastroduodenal morbidity with metabolic syndrome: a large cross-sectional study"],"prefix":"10.1038","volume":"8","author":[{"given":"Rotem","family":"Refaeli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Chodick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeda","family":"Haj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophy","family":"Goren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varda","family":"Shalev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-7559","authenticated-orcid":false,"given":"Khitam","family":"Muhsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"22198_CR1","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1464-5491.2006.01858.x","volume":"23","author":"KG Alberti","year":"2006","unstructured":"Alberti, K. 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