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Seroepidemiology for chlamydia infection may be useful for determining the cumulative risk of infection within a population. Initial studies using the<jats:italic>Chlamydia trachomatis<\/jats:italic>immunodominant antigen Pgp3 have shown utility for seroepidemiology of sexually transmitted chlamydia and the eye disease trachoma. We present our latent class modeling results for comparison of antibody data obtained from three different Pgp3-based platforms \u2013 multiplex bead array, ELISA, and lateral flow assay. Sensitivity and specificity estimates from the best fitting latent class models were similar to estimates derived from those previously obtained using a nucleic acid amplification test as a gold standard for sensitivity and non-endemic pediatric specimens for specificity, although the estimates from latent class models had wider confidence intervals. The modeling process and evaluation highlighted the importance of including as many antibody tests as possible when fitting a latent class model to ensure that as many patterns as possible are available for evaluation. Future studies designed to evaluate antibody test performance in the absence of a gold standard should utilize as many tests as possible.<\/jats:p>","DOI":"10.1038\/s41598-018-22708-9","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T10:42:20Z","timestamp":1520246540000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Latent class modeling to compare testing platforms for detection of antibodies against the Chlamydia trachomatis antigen Pgp3"],"prefix":"10.1038","volume":"8","author":[{"given":"Ryan E.","family":"Wiegand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen","family":"Cooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brook","family":"Goodhew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Banniettis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kohlhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Gwyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana L.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"22708_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/sim.4780050105","volume":"5","author":"D Rindskopf","year":"1986","unstructured":"Rindskopf, D. & Rindskopf, W. 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