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Simultaneous invasive ICP and radial artery BP waveforms were measured in 29 individuals with idiopathic normal pressure hydrocephalus (iNPH). The central aortic BP waveforms were estimated from the radial artery BP waveforms using the SphygmoCor system. For each individual, a transfer function estimate between the central aortic BP and the invasive ICP waveforms was found (Intra-patient approach). Thereafter, the transfer function estimate that gave the best fit was chosen and applied to the other individuals (Inter-patient approach). To validate the results, ICP waveform parameters were calculated for the estimates and the measured golden standard. For the Intra-patient approach, the mean absolute difference in invasive versus non-invasive mean ICP wave amplitude was 1.9\u2009\u00b1\u20091.0\u2009mmHg among the 29 individuals. Correspondingly, the Inter-patient approach resulted in a mean absolute difference of 1.6\u2009\u00b1\u20091.0\u2009mmHg for the 29 individuals. This method gave a fairly good estimate of the wave for about a third of the individuals, but the variability is quite large. This approach is therefore not a reliable method for use in clinical patient management.<\/jats:p>","DOI":"10.1038\/s41598-018-23142-7","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T15:36:25Z","timestamp":1520868985000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Non-invasive Estimation of the Intracranial Pressure Waveform from the Central Arterial Blood Pressure Waveform in Idiopathic Normal Pressure Hydrocephalus Patients"],"prefix":"10.1038","volume":"8","author":[{"given":"Karen Brastad","family":"Evensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"O\u2019Rourke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Prieur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverre","family":"Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6881-9280","authenticated-orcid":false,"given":"Per Kristian","family":"Eide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,16]]},"reference":[{"key":"23142_CR1","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1136\/jnnp.2003.033126","volume":"75","author":"M Czosnyka","year":"2004","unstructured":"Czosnyka, M. 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MOR is founding director of AtCor Medical, manufacturer of the SphygmoCor system. PKE has a financial interest in the software company (dPCom AS, Oslo) manufacturing the software (Sensometrics Software) used for analysis of the ICP recordings.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"4714"}}