{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:44:44Z","timestamp":1740163484092,"version":"3.37.3"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Here we report a retrospective cross-sectional study on Esophageal eosinophilia (EsEo) frequency in Brazil, for 2, 425 pediatric patients with symptoms associated with gastroesophageal diseases in 2012. EsEo is defined by \u226515 eosinophils per high power field (400x) and confirmed through histological analyses of esophageal biopsies. Overall, 126 patients had EsEo equating to a frequency of 5.2%. There was a significant difference between the endoscopic features of patients with EsEo, where 10.7% had erosive esophagitis, 3.0% had non-erosive esophagitis and 1% showed normal esophageal mucosa. According to the interaction of the variables in the Classification and Regression Tree Analysis, most patients diagnosed with EsEo were older males with erosive esophagitis. On the other hand, the lowest frequency of EsEo was found among younger females with non-erosive esophagitis\/normal mucosa. Environmental conditions, including climate variation and changes, were observed in association with EsEo, supporting a potential role for environmental factors in its pathogenesis. There was an inverse correlation between the number of EsEo, rainfall and humidity. EsEo is a relatively frequent finding in the pediatric population of Brazil with symptoms of gastroesophageal diseases. Both clinical and histological examinations of patients are important for a reliable diagnostic of EsEo cases and to patient care.<\/jats:p>","DOI":"10.1038\/s41598-018-23178-9","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T00:58:37Z","timestamp":1522285117000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Frequency of Esophageal Eosinophilia in a Pediatric Population from Central Brazil"],"prefix":"10.1038","volume":"8","author":[{"given":"Daniel","family":"Strozzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Aur\u00e9lio Silveira","family":"Botacin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilia Adriano","family":"Mekdessi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Ximenes","family":"Salustiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro H. de Paula","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lysa Bernardes","family":"Minasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gesmar Rodrigues Silva","family":"Segundo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0753-3814","authenticated-orcid":false,"given":"Aparecido Divino da","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"23178_CR1","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1146\/annurev-med-041610-134138","volume":"63","author":"JP Abonia","year":"2012","unstructured":"Abonia, J. P. & Rothenberg, M. E. Eosinophilic esophagitis: rapidly advancing insights. Ann Rev Med 63, 421\u2013434, https:\/\/doi.org\/10.1146\/annurev-med-041610-134138 (2012).","journal-title":"Ann Rev Med"},{"key":"23178_CR2","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1111\/jpc.12757","volume":"51","author":"KJ Allen","year":"2012","unstructured":"Allen, K. J. & Heine, R. Gc. J Paediatr Child Health 51, 512\u2013514, https:\/\/doi.org\/10.1111\/jpc.12757 (2012).","journal-title":"J Paediatr Child Health"},{"key":"23178_CR3","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/ACI.0b013e32813aee4a","volume":"7","author":"JM Spergel","year":"2007","unstructured":"Spergel, J. M. Eosinophilic esophagitis in adults and children: evidence for a food allergy component in many patients. Curr Opin Allergy Clin Immunol 7, 274\u2013278 (2007).","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"23178_CR4","doi-asserted-by":"crossref","unstructured":"Beausoleil, J. L. & Brown-Whitehorn, T. Allergic and atopic features of children with eosinophilic esophagitis. In: Liacouras, C. A. & Markowitz, J. E., editors. Eosinophilic Esophagitis; Humana Press. 239\u2013252 (2012).","DOI":"10.1007\/978-1-60761-515-6_17"},{"key":"23178_CR5","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1053\/j.gastro.2015.02.002","volume":"148","author":"ME Rothenberg","year":"2015","unstructured":"Rothenberg, M. E. Molecular, genetic, and cellular bases for treating eosinophilic esophagitis. Gastroenterology. 148, 1143\u20131157, https:\/\/doi.org\/10.1053\/j.gastro.2015.02.002 (2015).","journal-title":"Gastroenterology."},{"key":"23178_CR6","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.anai.2015.07.004","volume":"115","author":"G Ram","year":"2015","unstructured":"Ram, G. et al. Seasonal exacerbation of esophageal Eosinophilia in children with eosinophilic esophagitis and allergic rhinitis. 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