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Secreted OMVs play important roles in the ability of a bacterium to defend itself, and thus contribute to the survival of bacteria in a community. In this study, we collected OMVs from \u03b2-lactam antibiotic-resistant\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    established by conjugation assay and the parental \u03b2-lactam antibiotic-susceptible strain, and performed comparative proteomic analysis to examine whether these OMVs carried \u03b2-lactam-resistant compounds. We also investigated whether both types of OMVs could protect susceptible cells from \u03b2-lactam-induced death and\/or directly degrade \u03b2-lactam antibiotics. Several proteins that can be involved in degrading \u03b2-lactam antibiotics were more abundant in OMVs from \u03b2-lactam-resistant\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    , and thus OMVs from \u03b2-lactam resistant\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    could directly and dose-dependently degrade \u03b2-lactam antibiotics and fully rescue \u03b2-lactam-susceptible\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    and other bacterial species from \u03b2-lactam antibiotic-induced growth inhibition. Taken together, present study demonstrate that OMVs from \u03b2-lactam-resistant\n                    <jats:italic>E<\/jats:italic>\n                    .\n                    <jats:italic>coli<\/jats:italic>\n                    play important roles in survival of antibiotic susceptible bacteria against \u03b2-lactam antibiotics. This finding may pave the way for new efforts to combat the current global spread of antibiotic resistances, which is considered to be a significant public health threat.\n                  <\/jats:p>","DOI":"10.1038\/s41598-018-23656-0","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T22:09:18Z","timestamp":1522274958000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":125,"title":["Outer membrane vesicles from \u03b2-lactam-resistant Escherichia coli enable the survival of \u03b2-lactam-susceptible E. coli in the presence of \u03b2-lactam antibiotics"],"prefix":"10.1038","volume":"8","author":[{"given":"Si Won","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Bin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Pyeong","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Wook","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Won","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jassy Mary S.","family":"Lazarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaesung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Su","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Wook","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Suk","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwang Joong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ju","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk-Kyung","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Sung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,29]]},"reference":[{"key":"23656_CR1","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1128\/AAC.00929-10","volume":"55","author":"C Rumbo","year":"2011","unstructured":"Rumbo, C. et al. 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