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In humans, the same amyloid structures are mostly associated with neurodegenerative disorders such as Alzheimer\u2019s and Parkinson\u2019s. We here assessed a putative connection between these amyloids using recombinant Atlantic cod \u03b2-parvalbumin and the key amyloidogenic protein in Parkinson\u2019s disease, \u03b1-synuclein. Using a set of <jats:italic>in vitro<\/jats:italic> biophysical methods, we discovered that \u03b2-parvalbumin readily inhibits amyloid formation of \u03b1-synuclein. The underlying mechanism was found to involve \u03b1-synuclein binding to the surface of \u03b2-parvalbumin amyloid fibers. In addition to being a new amyloid inhibition mechanism, the data suggest that health benefits of fish may be explained in part by cross-reaction of \u03b2-parvalbumin with human amyloidogenic proteins.<\/jats:p>","DOI":"10.1038\/s41598-018-23850-0","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T02:23:53Z","timestamp":1522290233000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Abundant fish protein inhibits \u03b1-synuclein amyloid formation"],"prefix":"10.1038","volume":"8","author":[{"given":"Tony","family":"Werner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjeet","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-9025","authenticated-orcid":false,"given":"Nathalie","family":"Scheers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1058-1964","authenticated-orcid":false,"given":"Pernilla","family":"Wittung-Stafshede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,3]]},"reference":[{"key":"23850_CR1","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1111\/gbb.12172","volume":"13","author":"AY Chen","year":"2014","unstructured":"Chen, A. 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