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However, increases in myocardial free water also prolong native T1 times and may impact fibrosis quantification. Thus far, the impact of systemic patient volume status remains unclear. In this study, native T1 time by CMR was investigated in hemodialysis (HD) patients (n\u2009=\u200937) and compared with healthy controls (n\u2009=\u200935). Volume status was quantified by bioimpedance spectroscopy and correlated with CMR T1 time. While no differences between HD patients and controls were present with regard to age (p\u2009=\u20090.180), height (p\u2009=\u20090.535), weight (p\u2009=\u20090.559) and left ventricular (LV) ejection fraction (p\u2009=\u20090.273), cardiac size was significantly larger in HD patients (LV end-diastolic volume 164\u2009\u00b1\u200953 vs. 132\u2009\u00b1\u200926\u2009ml, p\u2009=\u20090.002). Fluid overloaded HD patients had significantly longer native T1 times than normovolemic HD patients and healthy controls (1,042\u2009\u00b1\u200946 vs. 1,005\u2009\u00b1\u200949 vs. 998\u2009\u00b1\u200947\u2009ms, p\u2009=\u20090.030). By regression analysis, T1 time was significantly associated with fluid status (r\u2009=\u20090.530, p\u2009=\u20090.009, post-HD fluid status). Our data strongly indicate that native CMR T1 time is significantly influenced by systemic volume status. As fluid overload is common in patients with cardiovascular diseases, this finding is important and requires further study.<\/jats:p>","DOI":"10.1038\/s41598-018-23868-4","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T02:26:01Z","timestamp":1522290361000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of Systemic Volume Status on Cardiac Magnetic Resonance T1 Mapping"],"prefix":"10.1038","volume":"8","author":[{"given":"Marlies","family":"Antlanger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Aschauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas A.","family":"Kammerlander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Duca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus D.","family":"S\u00e4emann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Bonderman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Mascherbauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,4,3]]},"reference":[{"key":"23868_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jcmg.2015.11.005","volume":"9","author":"AJ Taylor","year":"2016","unstructured":"Taylor, A. 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