{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:58:27Z","timestamp":1780667907503,"version":"3.54.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T00:00:00Z","timestamp":1522800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T00:00:00Z","timestamp":1522800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Japan\u2019s governmental recommendation of HPV vaccine has now been suspended for more than 4 years. In and before 2013, the targets of 20-year-old cervical cancer screening were females born in and before 1993, i.e., those who could not have received HPV vaccination because it was not yet publicly introduced. The targets during 2014\u20132019 are, or will be, those born in 1994\u20131999, i.e., those who came of age during a period with the highest HPV immunization rate. We analyzed the statistical data for each birth year, for the cumulative HPV vaccination rates achieved as of age 16, and for the corresponding results of cervical cancer screening at age 20. The rate of abnormal findings in cervical cytology increased slightly from 3.68% in 2010 (birth year: 1990) to 4.35% in 2013 (birth year: 1993); however, it dynamically dropped to 2.99% in 2014 (birth year: 1994) and 3.03% in 2015 (birth year: 1995). In total, the rate of abnormal findings in cervical cytology was 3.96% in 2010\u20132013, but significantly dropped to 3.01% in 2014\u20132015 (<jats:italic>p<\/jats:italic>\u2009=\u20090.014). This is the first description of dynamic changes occurring in the abnormal rate of cervical cancer screening as a result of positive changes in national HPV vaccination rates.<\/jats:p>","DOI":"10.1038\/s41598-018-23947-6","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T22:23:35Z","timestamp":1522362215000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Dynamic changes in Japan\u2019s prevalence of abnormal findings in cervical cytology depending on birth year"],"prefix":"10.1038","volume":"8","author":[{"given":"Yutaka","family":"Ueda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asami","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomio","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Hirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Sekine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuko","family":"Miyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,4]]},"reference":[{"key":"23947_CR1","unstructured":"Japanese Ministry of Health, Labour and Welfare. Vital Statistics in Japan, tabulated by Center for Cancer Control and Information Services, National Cancer Center, Japan. Available at: http:\/\/ganjoho.jp\/pro\/statistics\/en\/table_download.html (Accessed on September 9, 2017)."},{"key":"23947_CR2","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.canep.2015.08.001","volume":"39","author":"Y Motoki","year":"2015","unstructured":"Motoki, Y. et al. Increasing trends in cervical cancer mortality among young Japanese women below the age of 50 years: an analysis using the Kanagawa population-based Cancer Registry, 1975\u20132012. Cancer Epidemiol. 39, 700\u20136 (2015).","journal-title":"Cancer Epidemiol."},{"key":"23947_CR3","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.ajog.2014.11.037","volume":"212","author":"Y Ueda","year":"2015","unstructured":"Ueda, Y. et al. Japan\u2019s failure to vaccinate girls against human papillomavirus. 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Lancet. 385, 2571 (2015).","journal-title":"Lancet."},{"key":"23947_CR7","first-page":"039","volume":"2","author":"M Sekine","year":"2016","unstructured":"Sekine, M. et al. Japanese Crisis of HPV Vaccination. Int. J Pathol Clin Res. 2, 039 (2016).","journal-title":"J Pathol Clin Res."},{"key":"23947_CR8","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1016\/S1470-2045(16)00147-9","volume":"17","author":"Y Tanaka","year":"2016","unstructured":"Tanaka, Y. et al. Outcomes for girls without HPV vaccination in Japan. Lancet Oncol. 17, 868\u2013869 (2016).","journal-title":"Lancet Oncol."},{"key":"23947_CR9","doi-asserted-by":"publisher","first-page":"184","DOI":"10.5694\/mja15.01038","volume":"204","author":"JM Brotherton","year":"2016","unstructured":"Brotherton, J. M., Gertig, D. M., May, C., Chappell, G. & Saville, M. HPV vaccine impact in Australian women: ready for an HPV-based screening program. Med J Aust. 204, 184\u2013184e1 (2016).","journal-title":"Med J Aust."},{"key":"23947_CR10","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1093\/cid\/ciw354","volume":"63","author":"SM Garland","year":"2016","unstructured":"Garland, S. M. et al. Impact and effectiveness of the quadrivalent Human Papillomavirus Vaccine: A systematic review of 10 years of real-world experience. Clin Infect Dis. 63, 519\u201327 (2016).","journal-title":"Clin Infect Dis."},{"key":"23947_CR11","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1620\/tjem.240.147","volume":"240","author":"N Ozawa","year":"2016","unstructured":"Ozawa, N., Ito, K., Tase, T., Metoki, H. & Yaegashi, N. Beneficial Effects of Human Papillomavirus Vaccine for Prevention of Cervical Abnormalities in Miyagi, Japan. Tohoku J Exp Med. 240, 147\u2013151 (2016).","journal-title":"Tohoku J Exp Med."},{"key":"23947_CR12","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1111\/jog.13419","volume":"43","author":"H Tanaka","year":"2017","unstructured":"Tanaka, H. et al. Preventive effect of human papillomavirus vaccination on the development of uterine cervical lesions in young Japanese women. J Obstet Gynaecol Res. 43, 1597\u20131601 (2017).","journal-title":"J Obstet Gynaecol Res."},{"key":"23947_CR13","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1002\/ijc.30855","volume":"141","author":"K Matsumoto","year":"2017","unstructured":"Matsumoto, K. et al. Early impact of the Japanese immunization program implemented before the HPV vaccination crisis. 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The error has been fixed in the paper.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"YU, EM and TE received lecture fees from GlaxoSmithKline\/Japan Vaccine. AY, YU and EM received a lecture fee from Merck Sharp & Dohme. YU received a research fund (grant number J550703673) from Merck Sharp & Dohme. EM and TE received research grants from GlaxoSmithKline and MSD. EM received honoraria from GlaxoSmithKline\/Japan Vaccine. This study was funded by a Health and Labour Sciences Research Grant from MHLW (grant number: H29\u2013024).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"5612"}}