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Mutations in the genes encoding the proteins of the retinoid cycle are the leading cause for recessively inherited retinal dystrophies such as retinitis pigmentosa, Leber congenital amaurosis, congenital cone-rod dystrophy and fundus albipunctatus. Currently there is no treatment for these blinding diseases. In previous studies we demonstrated that oral treatment with the 9-<jats:italic>cis<\/jats:italic>-\u03b2-carotene rich <jats:italic>Dunaliella Bardawil<\/jats:italic> algae powder significantly improved visual and retinal functions in patients with retinitis pigmentosa and fundus albipunctatus. Here we developed a convenient and economical synthetic route for biologically active 9-<jats:italic>cis<\/jats:italic>-\u03b2-carotene from inexpensive building materials and demonstrated that the molecule is stable for at least one month. Synthetic 9-<jats:italic>cis<\/jats:italic>-\u03b2-carotene rescued cone photoreceptors from degeneration in eye cup cultures of mice with a retinoid cycle genetic defect. This study suggests that synthetic 9-<jats:italic>cis<\/jats:italic>-\u03b2-carotene may serve as an effective treatment for retinal dystrophies involving the retinoid cycle.<\/jats:p>","DOI":"10.1038\/s41598-018-24439-3","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T15:58:47Z","timestamp":1523462327000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Synthetic 9-cis-beta-carotene inhibits photoreceptor degeneration in cultures of eye cups from rpe65rd12 mouse model of retinoid cycle defect"],"prefix":"10.1038","volume":"8","author":[{"given":"Ifat","family":"Sher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Tzameret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Peri-Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Edelshtain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ioffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Sayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Buzhansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Gazit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ygal","family":"Rotenstreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"24439_CR1","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1146\/annurev.pharmtox.47.120505.105225","volume":"47","author":"GH Travis","year":"2007","unstructured":"Travis, G. 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TEVA Pharmaceuticals had no role in the design or conduct of this research. IS, LB, AS, MI, EG and YR \u2013 patent application (Tel Aviv University, Israel). All authors declare no non-financial interests in relation to the work described.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"6130"}}