{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:18:39Z","timestamp":1793837919406,"version":"4.6.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>NK cells are important in innate immunity for their capacity to kill infected or cancer cells. The killer cell immunoglobulin-like receptors (KIR) are a family of polymorphic genes with inhibitory and activating functions. The main driving force for gastric cancer (GC) development is a chronic response, which causes an increase of NK cells in the gastric mucosa. The aim of this work was to study polymorphisms in KIR genes in patients with either GC or non-atrophic gastritis (NAG). We studied 242 patients (130 with NAG and 112 with GC) and contrasted with 146 asymptomatic individuals. We analyzed diversity in the content and localization of KIR genes in the different clinical groups studied. Four activating and one inhibitory genes were associated with GC: 2DS1 (OR 3.41), 2DS3 (OR 4.66), 2DS5 (OR 2.25), 3DS1 (OR 3.35) and 2DL5 (OR 3.6). The following were also found as risk factors for GC: Bx genotype (OR 4.2), Bx-Bx centromere-telomere (OR 2.55), cA01|cB03 (OR 36.39) and tB01|tB01 (OR 7.55) gene content and three B motifs (OR 10.9). Polymorphisms in KIR genes were associated with GC and suggest that mutated NK cells may contribute to GC development by increasing gastric mucosa inflammation, leading to constant tissue damage.<\/jats:p>","DOI":"10.1038\/s41598-018-24464-2","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T11:30:37Z","timestamp":1523446237000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Genotype B of Killer Cell Immunoglobulin-Like Receptor is Related with Gastric Cancer Lesions"],"prefix":"10.1038","volume":"8","author":[{"given":"Eric G.","family":"Hernandez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswaldo","family":"Partida-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Camorlinga-Ponce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Nieves-Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Ramos-Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1265-7769","authenticated-orcid":false,"given":"Martha","family":"Perez-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"24464_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1126\/science.1198687","volume":"331","author":"E Vivier","year":"2011","unstructured":"Vivier, E. et al. Innate or adaptive immunity? The example of natural killer cells. Science 331, 44\u201349, https:\/\/doi.org\/10.1126\/science.1198687 (2011).","journal-title":"Science"},{"key":"24464_CR2","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/gene.2008.34","volume":"9","author":"D Ordonez","year":"2008","unstructured":"Ordonez, D. et al. Duplication, mutation and recombination of the human orphan gene KIR2DS3 contribute to the diversity of KIR haplotypes. Genes Immun 9, 431\u2013437, https:\/\/doi.org\/10.1038\/gene.2008.34 (2008).","journal-title":"Genes Immun"},{"key":"24464_CR3","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/S0198-8859(03)00089-2","volume":"64","author":"F Williams","year":"2003","unstructured":"Williams, F. et al. Multiple copies of KIR 3DL\/S1 and KIR 2DL4 genes identified in a number of individuals. Hum Immunol 64, 729\u2013732, https:\/\/doi.org\/10.1016\/S0198-8859(03)00089-2 (2003).","journal-title":"Hum Immunol"},{"key":"24464_CR4","doi-asserted-by":"publisher","first-page":"4778","DOI":"10.1073\/pnas.080588597","volume":"97","author":"MJ Wilson","year":"2000","unstructured":"Wilson, M. J. et al. Plasticity in the organization and sequences of human KIR\/ILT gene families. Proc Natl Acad Sci USA 97, 4778\u20134783, https:\/\/doi.org\/10.1073\/pnas.080588597 (2000).","journal-title":"Proc Natl Acad Sci USA"},{"key":"24464_CR5","doi-asserted-by":"publisher","first-page":"5118","DOI":"10.4049\/jimmunol.169.9.5118","volume":"169","author":"KC Hsu","year":"2002","unstructured":"Hsu, K. C. et al. Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets. J Immunol 169, 5118\u20135129, https:\/\/doi.org\/10.4049\/jimmunol.169.9.5118 (2002).","journal-title":"J Immunol"},{"key":"24464_CR6","doi-asserted-by":"publisher","first-page":"6416","DOI":"10.4049\/jimmunol.165.11.6416","volume":"165","author":"C Vilches","year":"2000","unstructured":"Vilches, C., Gardiner, C. M. & Parham, P. Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene. J Immunol 165, 6416\u20136421, https:\/\/doi.org\/10.4049\/jimmunol.165.11.6416 (2000).","journal-title":"J Immunol"},{"key":"24464_CR7","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S0952-7915(00)00242-9","volume":"13","author":"CW McMahon","year":"2001","unstructured":"McMahon, C. W. & Raulet, D. H. Expression and function of NK cell receptors in CD8+ T cells. Curr Opin Immunol 13, 465\u2013470, https:\/\/doi.org\/10.1016\/S0952-7915(00)00242-9 (2001).","journal-title":"Curr Opin Immunol"},{"key":"24464_CR8","doi-asserted-by":"publisher","first-page":"2767","DOI":"10.4049\/jimmunol.180.5.2767","volume":"180","author":"N Remtoula","year":"2008","unstructured":"Remtoula, N., Bensussan, A. & Marie-Cardine, A. Cutting edge: selective expression of inhibitory or activating killer cell Ig-like receptors in circulating CD4+ T lymphocytes. J Immunol 180, 2767\u20132771, https:\/\/doi.org\/10.4049\/jimmunol.180.5.2767 (2008).","journal-title":"J Immunol"},{"key":"24464_CR9","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.coi.2012.01.001","volume":"24","author":"A Thielens","year":"2012","unstructured":"Thielens, A., Vivier, E. & Romagn\u00e9, F. NK cell MHC class I specific receptors (KIR): from biology to clinical intervention. Curr Opin Immunol 24, 239\u2013245, https:\/\/doi.org\/10.1016\/j.coi.2012.01.001 (2012).","journal-title":"Curr Opin Immunol"},{"key":"24464_CR10","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/gene.2015.56","volume":"17","author":"H Li","year":"2016","unstructured":"Li, H., Wright, P. W., McCullen, M. & Anderson, S. K. Characterization of KIR intermediate promoters reveals four promoter types associated with distinct expression patterns of KIR subtypes. Genes Immun 17, 66\u201374, https:\/\/doi.org\/10.1038\/gene.2015.56 (2016).","journal-title":"Genes Immun"},{"key":"24464_CR11","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.4049\/jimmunol.174.7.4135","volume":"174","author":"HI Trompeter","year":"2005","unstructured":"Trompeter, H. I. et al. Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3. J Immunol 174, 4135\u20134143, https:\/\/doi.org\/10.4049\/jimmunol.174.7.4135 (2005).","journal-title":"J Immunol"},{"key":"24464_CR12","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/eji.200425743","volume":"35","author":"M Uhrberg","year":"2005","unstructured":"Uhrberg, M. The KIR gene family: life in the fast lane of evolution. Eur J Immunol 35, 10\u201315, https:\/\/doi.org\/10.1002\/eji.200425743 (2005).","journal-title":"Eur J Immunol"},{"key":"24464_CR13","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1365-2567.2009.03208.x","volume":"129","author":"D Middleton","year":"2010","unstructured":"Middleton, D. & Gonzelez, F. The extensive polymorphism of KIR genes. Immunology 129, 8\u201319, https:\/\/doi.org\/10.1111\/j.1365-2567.2009.03208.x (2010).","journal-title":"Immunology"},{"key":"24464_CR14","doi-asserted-by":"publisher","unstructured":"Jiang, W. et al. Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors. Genome Res 22, 1845\u20131854, https:\/\/doi.org\/10.1101\/gr.137976.112 (2012).","DOI":"10.1101\/gr.137976.112"},{"key":"24464_CR15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/gene.2011.52","volume":"13","author":"L Hou","year":"2012","unstructured":"Hou, L., Chen, M., Ng, J. & Hurley, C. K. Conserved KIR allele-level haplotypes are altered by microvariation in individuals with European ancestry. Genes Immun 13, 47\u201358, https:\/\/doi.org\/10.1038\/gene.2011.52 (2012).","journal-title":"Genes Immun"},{"key":"24464_CR16","doi-asserted-by":"publisher","first-page":"e15115","DOI":"10.1371\/journal.pone.0015115","volume":"5","author":"CW Pyo","year":"2010","unstructured":"Pyo, C. W. et al. Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus. PLoS One 5, e15115, https:\/\/doi.org\/10.1371\/journal.pone.0015115 (2010).","journal-title":"PLoS One"},{"key":"24464_CR17","doi-asserted-by":"publisher","first-page":"e47491","DOI":"10.1371\/journal.pone.0047491","volume":"7","author":"C Vierra-Green","year":"2012","unstructured":"Vierra-Green, C. et al. Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals. PLoS One 7, e47491, https:\/\/doi.org\/10.1371\/journal.pone.0047491 (2012).","journal-title":"PLoS One"},{"key":"24464_CR18","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1182\/blood-2010-05-283051","volume":"116","author":"S Cooley","year":"2010","unstructured":"Cooley, S. et al. Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia. Blood 116, 2411\u20132419, https:\/\/doi.org\/10.1182\/blood-2010-05-283051 (2010).","journal-title":"Blood"},{"key":"24464_CR19","doi-asserted-by":"publisher","first-page":"621","DOI":"10.11622\/smedj.2014174","volume":"55","author":"TL Ang","year":"2014","unstructured":"Ang, T. L. & Fock, K. M. Clinical epidemiology of gastric cancer. Singapore Med J 55, 621\u2013628, https:\/\/doi.org\/10.11622\/smedj.2014174 (2014).","journal-title":"Singapore Med J"},{"key":"24464_CR20","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/S0188-4409(00)00099-0","volume":"31","author":"J Torres","year":"2000","unstructured":"Torres, J. et al. A Comprehensive Review of the Natural History of Helicobacter pylori Infection in Children. Archives of Medical Research 31, 431\u2013469, https:\/\/doi.org\/10.1016\/S0188-4409(00)00099-0 (2000).","journal-title":"Archives of Medical Research"},{"key":"24464_CR21","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.4049\/jimmunol.173.2.1249","volume":"173","author":"N Hafsi","year":"2004","unstructured":"Hafsi, N. et al. Human dendritic cells respond to Helicobacter pylori, promoting NK cell and Th1-effector responses in vitro. J Immunol 173, 1249\u20131257, https:\/\/doi.org\/10.4049\/jimmunol.173.2.1249 (2004).","journal-title":"J Immunol"},{"key":"24464_CR22","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1080\/00365529850171639","volume":"33","author":"N Agnihotri","year":"1998","unstructured":"Agnihotri, N. et al. Characterization of lymphocytic subsets and cytokine production in gastric biopsy samples from Helicobacter pylori patients. Scand J Gastroenterol 33, 704\u2013709, https:\/\/doi.org\/10.1080\/00365529850171639 (1998).","journal-title":"Scand J Gastroenterol"},{"key":"24464_CR23","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1128\/iai.61.7.3012-3016.1993","volume":"61","author":"J Tarkkanen","year":"1993","unstructured":"Tarkkanen, J., Kosunen, T. U. & Saksela, E. Contact of lymphocytes with Helicobacter pylori augments natural killer cell activity and induces production of gamma interferon. Infect Immun 61, 3012\u20133016 (1993).","journal-title":"Infect Immun"},{"key":"24464_CR24","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/imm.12684","volume":"150","author":"V Beziat","year":"2017","unstructured":"Beziat, V., Hilton, H. G., Norman, P. J. & Traherne, J. A. Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology. Immunology 150, 248\u2013264, https:\/\/doi.org\/10.1111\/imm.12684 (2017).","journal-title":"Immunology"},{"key":"24464_CR25","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s12032-011-9932-x","volume":"29","author":"OG Ozturk","year":"2012","unstructured":"Ozturk, O. G., Gun, F. D. & Polat, G. Killer cell immunoglobulin-like receptor genes in patients with breast cancer. Med Oncol 29, 511\u2013515, https:\/\/doi.org\/10.1007\/s12032-011-9932-x (2012).","journal-title":"Med Oncol"},{"key":"24464_CR26","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.4238\/2012.May.15.7","volume":"11","author":"C Lu","year":"2012","unstructured":"Lu, C. et al. Association of killer cell immunoglobulin-like receptors with pulmonary tuberculosis in Chinese Han. Genet Mol Res 11, 1370\u20131378, https:\/\/doi.org\/10.4238\/2012.May.15.7 (2012).","journal-title":"Genet Mol Res"},{"key":"24464_CR27","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/cei.12568","volume":"180","author":"R Diaz-Pena","year":"2015","unstructured":"Diaz-Pena, R. et al. Activating killer immunoglobulin-like receptors genes are associated with increased susceptibility to ankylosing spondylitis. Clin Exp Immunol 180, 201\u2013206, https:\/\/doi.org\/10.1111\/cei.12568 (2015).","journal-title":"Clin Exp Immunol"},{"key":"24464_CR28","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1155\/2012\/486320","volume":"33","author":"S Ramirez-De los Santos","year":"2012","unstructured":"Ramirez-De los Santos, S. et al. Associations of killer cell immunoglobulin- like receptor genes with rheumatoid arthritis. Dis Markers 33, 201\u2013206, https:\/\/doi.org\/10.3233\/DMA-2012-0927 (2012).","journal-title":"Dis Markers"},{"key":"24464_CR29","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.gdata.2016.10.010","volume":"10","author":"K Ghanadi","year":"2016","unstructured":"Ghanadi, K., Shayanrad, B., Ahmadi, S. A., Shahsavar, F. & Eliasy, H. Colorectal cancer and the KIR genes in the human genome: A meta-analysis. Genom Data 10, 118\u2013126, https:\/\/doi.org\/10.1016\/j.gdata.2016.10.010 (2016).","journal-title":"Genom Data"},{"key":"24464_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-262","volume":"11","author":"YP Peng","year":"2013","unstructured":"Peng, Y. P. et al. Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer. J Transl Med 11, 262, https:\/\/doi.org\/10.1186\/1479-5876-11-262 (2013).","journal-title":"J Transl Med"},{"key":"24464_CR31","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.humimm.2005.01.001","volume":"66","author":"A Lopez-Vazquez","year":"2005","unstructured":"Lopez-Vazquez, A. et al. Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population. Hum Immunol 66, 285\u2013289, https:\/\/doi.org\/10.1016\/j.humimm.2005.01.001 (2005).","journal-title":"Hum Immunol"},{"key":"24464_CR32","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1111\/j.1399-0039.2007.00824.x","volume":"69","author":"AC Flores","year":"2007","unstructured":"Flores, A. C. et al. KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations. Tissue Antigens 69, 568\u2013576, https:\/\/doi.org\/10.1111\/j.1399-0039.2007.00824.x (2007).","journal-title":"Tissue Antigens"},{"key":"24464_CR33","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.smim.2008.06.003","volume":"20","author":"S Kulkarni","year":"2008","unstructured":"Kulkarni, S., Martin, M. P. & Carrington, M. The Yin and Yang of HLA and KIR in human disease. Semin Immunol 20, 343\u2013352, https:\/\/doi.org\/10.1016\/j.smim.2008.06.003 (2008).","journal-title":"Semin Immunol"},{"key":"24464_CR34","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1158\/0008-5472.CAN-15-0547","volume":"76","author":"KA Vineretsky","year":"2016","unstructured":"Vineretsky, K. A. et al. Skin Cancer Risk Is Modified by KIR\/HLA Interactions That Influence the Activation of Natural Killer Immune Cells. Cancer Res 76, 370\u2013376, https:\/\/doi.org\/10.1158\/0008-5472.CAN-15-0547 (2016).","journal-title":"Cancer Res"},{"key":"24464_CR35","doi-asserted-by":"publisher","first-page":"e84940","DOI":"10.1371\/journal.pone.0089993","volume":"9","author":"V De R","year":"2014","unstructured":"De R, V. et al. Genetic diversity of the KIR\/HLA system and outcome of patients with metastatic colorectal cancer treated with chemotherapy. PLoS One 9, e84940, https:\/\/doi.org\/10.1371\/journal.pone.0084940 (2014).","journal-title":"PLoS One"},{"key":"24464_CR36","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1158\/2326-6066.CIR-16-0152","volume":"5","author":"LS Peng","year":"2017","unstructured":"Peng, L. S. et al. Tumor-Associated Monocytes\/Macrophages Impair NK-Cell Function via TGFbeta1 in Human Gastric Cancer. Cancer Immunol Res 5, 248\u2013256, https:\/\/doi.org\/10.1158\/2326-6066.CIR-16-0152 (2017).","journal-title":"Cancer Immunol Res"},{"key":"24464_CR37","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1590\/S0102-67202012000200011","volume":"25","author":"D Rosso","year":"2012","unstructured":"Rosso, D. et al. Correlation of natural killer cells with the prognosis of gastric adenocarcinoma. Arq Bras Cir Dig 25, 114\u2013117, https:\/\/doi.org\/10.1590\/S0102-67202012000200011 (2012).","journal-title":"Arq Bras Cir Dig"},{"key":"24464_CR38","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3389\/fimmu.2014.00184","volume":"5","author":"MA Ivarsson","year":"2014","unstructured":"Ivarsson, M. A., Michaelsson, J. & Fauriat, C. Activating killer cell Ig-like receptors in health and disease. Front Immunol 5, 184, https:\/\/doi.org\/10.3389\/fimmu.2014.00184 (2014).","journal-title":"Front Immunol"},{"key":"24464_CR39","doi-asserted-by":"publisher","first-page":"5222","DOI":"10.4049\/jimmunol.175.8.5222","volume":"175","author":"WH Carr","year":"2005","unstructured":"Carr, W. H., Pando, M. J. & Parham, P. KIR3DL1 polymorphisms that affect NK cell inhibition by HLA-Bw4 ligand. J Immunol 175, 5222\u20135229, https:\/\/doi.org\/10.4049\/jimmunol.175.8.5222 (2005).","journal-title":"J Immunol"},{"key":"24464_CR40","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/j.1365-2567.2008.03027.x","volume":"126","author":"A Poli","year":"2009","unstructured":"Poli, A. et al. CD56bright natural killer (NK) cells: an important NK cell subset. Immunology 126, 458\u2013465, https:\/\/doi.org\/10.1111\/j.1365-2567.2008.03027.x (2009).","journal-title":"Immunology"},{"key":"24464_CR41","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1046\/j.1365-2036.2002.01301.x","volume":"16","author":"M Rugge","year":"2002","unstructured":"Rugge, M. et al. Gastric mucosal atrophy: interobserver consistency using new criteria for classification and grading. Aliment Pharmacol Ther 16, 1249\u20131259, https:\/\/doi.org\/10.1046\/j.1365-2036.2002.01301.x (2002).","journal-title":"Aliment Pharmacol Ther"},{"key":"24464_CR42","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s00251-011-0540-x","volume":"63","author":"DL Alvarado-Hern\u00e1ndez","year":"2011","unstructured":"Alvarado-Hern\u00e1ndez, D. L., Hern\u00e1ndez-Ram\u00edrez, D., Noyola, D. E. & Garc\u00eda-Sep\u00falveda, C. A. KIR gene diversity in Mexican mestizos of San Luis Potos\u00ed. Immunogenetics 63, 561\u2013575, https:\/\/doi.org\/10.1007\/s00251-011-0540-x (2011).","journal-title":"Immunogenetics"},{"key":"24464_CR43","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.humimm.2005.11.007","volume":"67","author":"ME Guti\u00e9rrez-Rodr\u00edguez","year":"2006","unstructured":"Guti\u00e9rrez-Rodr\u00edguez, M. E. et al. KIR Gene in Ethnic and Mestizo Populations from Mexico. Immunogenetics 67, 85\u201393, https:\/\/doi.org\/10.1016\/j.humimm.2005.11.007 (2006).","journal-title":"Immunogenetics"},{"key":"24464_CR44","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1399-0039.2006.76212.x","volume":"69","author":"G Contreras","year":"2007","unstructured":"Contreras, G. et al. Distribution of the killer cell immunoglobulin-like receptors in Mexican Mestizos. Tissue Antigens 69, 125\u2013129, https:\/\/doi.org\/10.1111\/j.1399-0039.2006.76212.x (2007).","journal-title":"Tissue Antigens"},{"key":"24464_CR45","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.humimm.2017.07.010","volume":"78","author":"AC Machado-Sulbaran","year":"2017","unstructured":"Machado-Sulbaran, A. C. et al. Distribution of KIR genes and KIR2DS4 gene variants in two Mexican Mestizo populations. Human Immunology 78, 614\u2013620, https:\/\/doi.org\/10.1016\/j.humimm.2017.07.010 (2017).","journal-title":"Human Immunology"},{"key":"24464_CR46","unstructured":"Genta, R. M. In Surgical Pathology of the GI tract, liver, biliary tract and pancreas (eds Odze, R. D. Goldblum, J. R. & Crawford J. M.) Ch. 8, 169 (Saunders, 2004)."},{"key":"24464_CR47","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miller","year":"1988","unstructured":"Miller, S. A., Dykes, D. D. & Polesky, H. F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Research 16, 1215 (1988).","journal-title":"Nucleic Acid Research"},{"key":"24464_CR48","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1111\/j.1572-0241.1998.00407.x","volume":"93","author":"M Camorlinga-Ponce","year":"1998","unstructured":"Camorlinga-Ponce, M. et al. Validation of a serologic test for the diagnosis of Helicobacter pylori infection and the immune response to urease and CagA in children. Am J Gastroenterol 93, 1264\u20131270, https:\/\/doi.org\/10.1111\/j.1572-0241.1998.00407.x (1998).","journal-title":"Am J Gastroenterol"},{"key":"24464_CR49","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1590\/S1135-57272004000200013","volume":"78","author":"X Hervada Vidal","year":"2004","unstructured":"Hervada Vidal, X. et al. Epidat 3.0 programa para analisis epidemiol\u00f3gico de datos tabulados. Rev Esp Salud Publica 78, 277\u2013280 (2004).","journal-title":"Rev Esp Salud Publica"},{"key":"24464_CR50","unstructured":"Petrie, A. & Sabin, C. Medical statistics at a glance. First edn, 78\u201379 (Blackwell Science Ltd, 2000)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-24464-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-24464-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-24464-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T04:29:53Z","timestamp":1671596993000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-018-24464-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["24464"],"URL":"https:\/\/doi.org\/10.1038\/s41598-018-24464-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"assertion":[{"value":"24 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"6104"}}