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Consecutive women with histologically verified CIN and observational management were included. Histologic findings of initial and follow-up visits were collected and persistence, progression and regression rates at end of observational period were assessed. Uni- and multivariate analyses were performed. A systematic review of the literature and meta-analysis was performed. In 783 women CIN I, II, and III was diagnosed by colposcopically guided biopsy in 42.5%, 26.6% and 30.9%, respectively. Younger patients had higher rates of regression (p\u2009&lt;\u20090.001) and complete remission (&lt;\u20090.001) and lower rates of progression (p\u2009=\u20090.003). Among women aged &lt;\u200925, 25\u2009&lt;\u200930, 30\u2009&lt;\u200935, 35\u2009&lt;\u200940 years, and\u2009&gt;\u200940 years, regression rates were 44.7%, 33.7%, 30.9%, 27.3%, and 24.9%, respectively. Pooled analysis of published data showed similar results. Multivariable analysis showed that with each five years of age, the odds for regression reduced by 21% (p\u2009&lt;\u20090.001) independently of CIN grade (p\u2009&lt;\u20090.001), and presence of HPV high-risk infection (p\u2009&lt;\u20090.001). Patient\u2019s age has a considerable influence on the natural history of CIN \u2013 independent of CIN grade and HPV high-risk infection. Observational management should be considered for selected young patients with CIN.<\/jats:p>","DOI":"10.1038\/s41598-018-24882-2","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T11:01:02Z","timestamp":1523962862000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Influence of age on histologic outcome of cervical intraepithelial neoplasia during observational management: results from large cohort, systematic review, meta-analysis"],"prefix":"10.1038","volume":"8","author":[{"given":"Christine","family":"Bekos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Schwameis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Heinze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"G\u00e4rner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Joura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Horvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Polterauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella","family":"Polterauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,23]]},"reference":[{"key":"24882_CR1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ajog.2004.01.043","volume":"191","author":"RP Insinga","year":"2004","unstructured":"Insinga, R. 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