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The aspergillosis mortality rate and emergence of drug-resistance reveals an urgent need to identify novel targets. Secreted and cell membrane proteins play a critical role in fungal-host interactions and pathogenesis. Using a computational pipeline integrating data from high-throughput experiments and bioinformatic predictions, we have identified secreted and cell membrane proteins in ten\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    species known to cause aspergillosis. Small secreted and effector-like proteins similar to agents of fungal-plant pathogenesis were also identified within each secretome. A comparison with humans revealed that at least 70% of\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    secretomes have no sequence similarity with the human proteome. An analysis of antigenic qualities of\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    proteins revealed that the secretome is significantly more antigenic than cell membrane proteins or the complete proteome. Finally, overlaying an expression dataset, four\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    proteins upregulated during infection and with available structures, were found to be structurally similar to known drug target proteins in other organisms, and were able to dock\n                    <jats:italic>in silico<\/jats:italic>\n                    with the respective drug.\n                  <\/jats:p>","DOI":"10.1038\/s41598-018-25016-4","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T10:10:59Z","timestamp":1524219059000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Comparative systems analysis of the secretome of the opportunistic pathogen Aspergillus fumigatus and other Aspergillus species"],"prefix":"10.1038","volume":"8","author":[{"given":"R. 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